Ideal Dose of Iron in Multiple Micronutrient Supplement: A Narrative Review of Evidence.

Anemia is a significant public health problem in low- and middle-income countries (LMICs). The co-existence of other micronutrient deficiencies and iron deficiency among pregnant women may be the reason for the inability to control anemia through iron and folic acid (IFA) supplementation. Multiple micronutrient supplementation (MMS) in pregnancy may help to overcome this problem. However, the recent World Health Organization (WHO) guidelines on MMS supplementation in pregnancy raised concerns regarding the adequacy of a 30mg iron dose in the MMS supplements in LMICs. The review summarized the literature to answer this question. Though most studies showed a comparable effect of MMS with 30mg iron and IFA with 60mg iron on maternal anemia outcomes, anemia persisted in the third trimester in both groups. There is a need to consider the use of a higher iron dose in MMS, especially in LMICs, to combat the problem of anemia, alongside correcting other micronutrient deficiencies.

Effect of iron-fortified rice on the hemoglobin level of the individuals aged more than six months: A meta-analysis of controlled trials.

Fortification of staple food items with iron is a potential strategy to address anemia for a larger population. We reviewed studies to assess the impact of iron-fortified rice (IFR) on hemoglobin levels of individuals more than six months of age. We included studies assessing the effectiveness of IFR (with or without other micronutrients) conducted in any part of the world available in PubMed, Embase, Web of Science, Cochrane Library, Google Scholar, clinicaltrials.gov, International database of prospectively registered systematic reviews in health and social care (PROSPERO), unicef.org, and who.int databases and published from January 1, 1990 to April 1, 2019 (PROSPERO registration number: RD42020139895). We extracted the changes in hemoglobin, serum ferritin, and serum transferrin levels among the participants. Finally, data from 15 trials and their 21 subsets were analyzed. Mean difference in hemoglobin was 0.53 g/dl (95% CI: 0.26, 0.80, P < 0.001, I2 = 84%) in the IFR group compared to the control group. In the subgroup analysis after removing studies with small sample size and high risk for bias, a mean difference of 0.44 g/dl (95% CI: 0.20, 0.69, P < 0.001, I2 = 82%) was observed. No significant effect on serum ferritin or transferrin levels was observed. From this review it can be concluded that fortification of rice with iron can be adopted as an intervention to improve hemoglobin levels, especially in countries where rice is the major part food of staple diet. Research is needed on an optimal iron compound for fortification and the acceptance of IFR.

Feasibility of Real-Time Monitoring for Anemia Using Mobile Application Linked With Point-of-Care Testing Device.

Background Anemia testing using digital hemoglobinometers (DH) enabled with real-time data visibility improves delivery outcomes, reduces the manual process of keeping records, and strengthens follow-up. In this study, testing of anemia was done by HealthTrender, an innovative mobile-based cloud-connected application, with HemoCue 301 device (HemoCue AB, Ängelholm, Sweden). Aim The objective of the study was to assess the feasibility, acceptability and coverage of anemia testing by the HealthTrender mobile application by the end users - Auxiliary Nursing Midwives (ANMs). Material and methods An exploratory mixed-method study was conducted for three months, i.e., from 1st January 2020 to 31st March 2020. The study was done at the antenatal clinics (ANCs) of two Primary Health Centres (PHCs) and their subcentres in the Ballabgarh block of Haryana, India. Qualitative data on the feasibility of the HealthTrender application was collected from 13 ANMs involved in the testing of anemia using in-depth interviews. Quantitative data of 1057 pregnant women attending the ANC clinics was also analysed. For data capturing, a Bluetooth dongle connected with HemoCue 301 transferred the hemoglobin (Hb) values to the HealthTrender mobile application and was uploaded to the cloud, displaying it on a webpage in real time. Result Among 1057 pregnant women enrolled, the mean (SD) hemoglobin was 10.9 gm/dl (1.5) and the prevalence of anemia was 47%. ANMs reported that the mobile application was easy to use, and half of them were very satisfied with its speed, easy uploading and quickness in reflecting Hb values on the mobile screen. Challenges related to internet connectivity, loss of Bluetooth dongle connection and less manpower with extra work required were expressed by the ANMs. Completion of records was significantly higher for the mobile application (100%) as compared to manual register-based records (81%). Conclusion Web-based application HealthTrender used by ANMs for screening pregnant women for anemia was feasible and had high acceptance. Using digital technology increases the reporting and coverage of hemoglobin testing. Information technology use may be highly beneficial for the serial recording of hemoglobin and subsequent management and follow-ups.