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(1) Background: The objective of this study was to investigate the potential of Salvadora oleoides (S. oleoides) and Salvadora persica (S. persica) polyphenols as antioxidant and anti-inflammatory agents. (2) Methods: Aerial parts and fruits of S. oleoides and S. persica were collected from the periphery of District Bhakkar, Punjab, Pakistan. Methanol extracts were prepared using the Soxhlet extraction technique. Extract yield varied from 8.15 to 19.6 g/100 g dry plant material. RP-HPLC revealed the detection of thirteen phenolic aids and five flavonoids. Gallic acid, hydroxy benzoic acid, chlorogenic acid, and cinamic acid were the major phenolic acids, whereas catechin, rutin, and myricetin were the flavonoids detected. (3) Results: Maximum total phenolic contents (TPCs) (22.2 mg/g of dry plant material) and total flavonoid contents (TFCs) (6.17 mg/g of dry plant material) were found in the fruit extract of S. persica, and the minimum TPC (11.9 mg/g) and TFC (1.72 mg/g) were found in the aerial part of S. oleoides. The fruit extract of S. persica showed the highest DPPH radical scavenging activity. In vivo anti-inflammatory activity of all the extracts was performed on albumin-induced rat paw edema that was comparable with the standard indomethacin; S. persica fruit extract showed remarkable anti-inflammatory activity. Analgesic activity of aerial part and fruit extracts of S. oleoides and S. persica was investigated using a mouse model, and the results showed that maximum possible analgesia of fruit extracts of S. persica was 53.44%, which is better than the PC group (52.98%). (4) Conclusions: The variations in the antioxidant, anti-inflammatory, and analgesic activities of methanolic extracts of S. oleoides and S. persica were found to be significant, and they have therapeutic potential as antioxidant, analgesic, and anti-inflammatory agents.
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INTRODUCTION: Archwires act as gears to move teeth with light, continuous forces. However, the intraoral use of orthodontic archwires is liable to surface deposits which alter the mechanical properties of archwires, causing an increase in the friction coefficient. OBJECTIVES: To evaluate the surface changes of the stainless steel archwires after 6 weeks of intraoral use and its influence on frictional resistance during sliding mechanics. MATERIALS AND METHODS: As-received rectangular 0.019" × 0.025" stainless steel orthodontic archwires (control) were compared with the archwires retrieved after the final phase of leveling and alignment stage of orthodontic treatment collected after 6 weeks of intraoral exposure (test samples) from 10 patients undergoing treatment. The control and test samples were used to evaluate surface debris using Scanning Electron Microscopy, surface roughness was assessed using Atomic Force Microscope and frictional forces were measured using Instron Universal Testing Machine in the buccal inter-bracket region that slides through the molar tube for space closure. Unpaired t-test and Pearson correlation tests were used for statistical analysis (P < 0.05 level of significance). RESULTS: Significant increase was observed in the level of debris (P = 0.0001), surface roughness (P = 0.0001), and friction resistance (P = 0.001) of orthodontic archwires after their intraoral exposure. Significant positive correlations (P < 0.05) were also observed between these three variables. CONCLUSION: Stainless steel test archwires showed a significant increase in the degree of debris and surface roughness, increasing the frictional forces between the archwire-bracket interfaces which would considerably reduce the normal orthodontic forces. Thus, continuing the same archwire after levelling and alignment for space closure is not recommended.
RESUMO
BACKGROUND: Our objectives are to analyse and to compare the stress distribution and displacement of the craniofacial structures, following the application of forces from quad-helix and Nickel Titanium Palatal Expander-2 (NPE2) using finite element analysis. METHODS: Three-dimensional finite element models of young dried human skull, quad-helix appliance and NPE2 were constructed, and the initial activation of the expanders was stimulated to carry out the analysis and to evaluate the Von Misses stresses and displacement. RESULTS: Both the models demonstrated the highest stresses at the mid-palatal suture, with maximum posterior dislocation. The second highest stress was recorded at the fronto-zygomatic suture. The pattern of stress distribution was almost similar in both the groups, but NPE2 revealed lower magnitude stresses than quad-helix. The only exception being quad-helix model showed high stress levels around pterygo-maxillary suture whereas minimal stress around pterygo-maxillary suture was noticed after NPE2 activation. The cusp of the erupting canine and the erupting mesiobuccal cusp of the second molar showed outward, backward and downward displacement signifying increase in their eruption pattern following maxillary expansion. CONCLUSIONS: Maxillary expansion using quad-helix and NPE2 can be used in posterior crossbite correction in cases where maximum skeletal changes are desirable at a younger age; it is furthermore effective in treating young patients with impacted or displaced teeth. Quad-helix and NPE2 produced acceptable forces for orthopaedic treatment even after being orthodontic appliances; their clinical application should be correctly planned as the effects of these appliances are largely age dependent.
