RESUMO
Models of simple and modified logistic function have been used for the quantitative characteristics of malaria infection development. The approach could be successfully used, which was demonstrated on experimental infection dynamics in rodents during parasitemia assessment both in absolute and logarithmic scales. Regression analysis of experimental data and choice of an optimal form of logistic equation are performed with the help of specially elaborated software. The calculated values of logistic parameters may be used for characterization of malaria parasite strains and isolates, their virulence and resistance, as well as the degree of their resistance to drugs.
Assuntos
Processamento Eletrônico de Dados/métodos , Malária/parasitologia , Plasmodium berghei , Animais , Análise dos Mínimos Quadrados , Modelos Logísticos , Malária/sangue , Camundongos , Microcomputadores , Linguagens de ProgramaçãoRESUMO
Universal computer software for primary statistical and graphic analysis of data on malaria dynamics in patients and in the experiment has been suggested. The analysis of the results of investigations on rodent malaria model in based on graded parasitemia assessment according to Moshkovskii [correction of Mashkovsky].
Assuntos
Processamento Eletrônico de Dados/métodos , Malária/parasitologia , Plasmodium berghei , Animais , Processamento Eletrônico de Dados/instrumentação , Malária/sangue , Microcomputadores , Linguagens de Programação , SoftwareRESUMO
Using a recurrent technique, P. berghei isolate resistant to chloroquine-fansidar combination is formed in golden hamsters. The isolate resistant to chloroquine-fansidar combination was 4 times less sensitive to chloroquine, 2 times less sensitive to fansidar and its combinations, 2 times less sensitive to sulfadoxine, 31 times less sensitive to pyrimethamine, as compared to the baseline isolate LNK65 P. berghei characterized by naturally reduced sensitivity to chloroquine.
