[Effect of therapy with lisinopril on the state of cerebral blood flow in women with hypertension in peri- and postmenopause]. / Vliianie terapii lizinoprilom na sostoianie tserebral'nogo krovotoka u zhenshchin s arterial'noi gipertenzieiv peri- i postmenopauze.

Blood flow in extra and intracranial arteries was assessed by doppler ultrasound in 26 hypertensive women without history of stroke. Studies were performed before treatment, after acute test with lisinopril and in 1 month of therapy with lisinopril. Baseline investigation revealed changes of velocity characteristics of blood flow and resistance indexes indicative of impaired cerebral hemodynamics both at extra- and intracranial level. After treatment with lisinopril signs of improvement of blood flow in extra- and intracranial arteries were found. Most important finding was normalization of ability of extracranial arteries to spasm and dilation presumably associated with restoration of hemodynamic reserve of cerebral vessels.

[Metabolic effects of quinapril in hepertensive patients]. / Metabolicheskie éffekty kvinaprila u bol'nykh arterial'nymi gipertoniiami.

AIM: The study of antihypertensive and metabolic effects of quinapril (accupro) in patients with essential hypertension (EH). MATERIALS AND METHODS: Serum levels of cholesterol, its fractions and triglycerides were measured and standard glucose tolerance test was made in 40 EH patients before accupro therapy and 1 and 3 months after continuous accupro treatment (10-20 mg/day). RESULTS: Antihypertensive effect of accupro was accompanied by marked improvement in carbohydrate and lipid metabolism in 28 patients. Normalization of blood pressure in the absence of negative effect of accupro on parameters of carbohydrate and lipid metabolism was recorded in 12 patients free of coexisting metabolic disorders. CONCLUSION: The results of the trial allow to recommend antihypertensive treatment with accupro as effective both in patients with metabolic disorders and free of them.