RESUMO
The article presents the summarized results of the controlled field trial of a new inactivated liquid absorbed tissue-culture vaccine developed in the USSR. The optimal immunization dose has been determined: 1.5 ml of the vaccine introduced with a syringe or a jet injector. The intensity and character of postvaccinal immunity have been studied.
Assuntos
Vírus da Encefalite Japonesa (Espécie)/imunologia , Encefalite Japonesa/prevenção & controle , Vacinas Virais/administração & dosagem , Anticorpos Antivirais/análise , Ensaios Clínicos como Assunto , Relação Dose-Resposta Imunológica , Humanos , Imunização Secundária , Injeções a Jato , Injeções Subcutâneas , Masculino , Fatores de Tempo , Vacinas Atenuadas/administração & dosagem , Vacinas Atenuadas/efeitos adversos , Vacinas Virais/efeitos adversosRESUMO
In this article the results of testing Soviet vaccines for the prophylaxis of Japanese encephalitis, cell-culture inactivated adsorbed liquid vaccine and brain-tissue purified dried vaccine, are generalized and the comparison of their reactogenicity and immunogenicity characteristics with those of a similar commercial preparation manufactured by Toshiba Kagaku Kogyo Co., Ltd. (Japan) is made. Cell-culture inactivated liquid vaccine has proved to be the optimal preparation: it produces the most prolonged and intensive immunity and, when introduced by two methods, shows low reactogenicity.