Demonstration of second-harmonic IVUS feasibility with focused broadband miniature transducers.

Focused broadband miniature polyvinylidene fluoride-trifluoroethylene (PVDF TrFE) ultrasonic transducers were investigated for intravascular (IVUS) second-harmonic imaging. Modeling and experimental studies demonstrated that focused transducers, unlike conventional flat transducers, build up second harmonic peak pressures faster and stronger, leading to an increased SNR of second harmonic content within the coronary geometry. Experimental results demonstrated that focused second harmonic pressures could be controlled to occur at specific depths by controlling the f-number of the transducer. The experimental results were in good agreement with the modeled results. Experiments were conducted using three imaging modalities: fundamental 20 MHz (F20), second harmonic 40 MHz (H40), and fundamental 40 MHz (F40). The lateral resolutions for a 1-mm transducer (f-number 3.2) at F20, F40, and H40 were experimentally measured to be 162, 123, and 124 microm, respectively, which agreed well with the theoretical calculations with <<8% error. Lateral resolution was further characterized in the three modes, using a micromachined phantom consisting of fixed bars and spaces with widths ranging from 20 to 160 microm. H40 exhibited better lateral resolution, clearly displaying 40- and 60-microm bars with about 4 dB and 7 dB greater signal strength compared with F20. Ex vivo human aorta images were obtained in the second-harmonic imaging mode to show the feasibility of high resolution second-harmonic IVUS using focused transducers.

Moderately nonlinear ultrasound propagation in blood-mimicking fluid.

In medical diagnostic ultrasound (US), higher than-in-water nonlinearity of body fluids and tissue usually does not produce strong nonlinearly distorted waves because of the high absorption. The relative influence of absorption and nonlinearity can be characterized by the Gol'dberg number Gamma. There are two limiting cases in nonlinear acoustics: weak waves (Gamma < 1) or strong waves (Gamma >> 1). However, at diagnostic frequencies in tissue and body fluids, the nonlinear effects and effects of absorption more likely are comparable (Gol'dberg number Gamma approximately 1). The aim of this work was to study the nonlinear propagation of a moderately nonlinear US second harmonic signal in a blood-mimicking fluid. Quasilinear solutions to the KZK equation are presented, assuming radiation from a flat and geometrically focused circular Gaussian source. The solutions are expressed in a new simplified closed form and are in very good agreement with those of previous studies measuring and modeling Gaussian beams. The solutions also show good agreement with the measurements of the beams produced by commercially available transducers, even without special Gaussian shading.

Free of speckle ultrasonic imaging of soft tissue with account of second harmonic signal.

The Born approximation deconvolved inverse scattering imaging technique is an alternative to the conventional pulse-echo method. This novel technique deconvolves the incident pulse from the reflected pulse, and uses the resulting impulse response to produce an image of the acoustic impedance distribution. It is applicable mainly to structures that resemble a layered medium. The images captured by this method prove to have improved resolution and are free of speckle. With this method one can use ultrasound of lower frequencies than would be required by the pulse-echo method to achieve the same resolution. To provide further improvement of images the second harmonic signals can be employed. Here we describe the deconvolved inverse scattering imaging technique with account of the second harmonic signal. For this purpose the hybrid transducer by Krautkramer Branson Co., which consists of a cylindrical 5 MHz transducer wrapped in an annulus-shaped 2.5 MHz transducer, has been used. The phantom and soft tissue were imaged and in both cases the account of the second harmonic reflection data provides an improvement of the image quality.