Your browser doesn't support javascript.
loading
Mostrar: 20 | 50 | 100
Resultados 1 - 2 de 2
Filtrar
Mais filtros










Base de dados
Intervalo de ano de publicação
1.
Drug Dev Ind Pharm ; 39(11): 1840-50, 2013 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-23167243

RESUMO

CONTEXT: Fatty liver is the first stage of alcoholic damage which is reversible with abstinence from alcohol. Mangiferin (MF) showed potent scavenging activity on diphenyl-1-picrylhydrazyl radicals which stimulate liver regeneration in various liver injuries. OBJECTIVE: Although, MF shows hepatoprotection against various liver disorders but due to rapid clearance and limited solubility in lipoid environment, there is problem of its poor absorption from intestine hence poor bioavailability. Owing to which there is a need to develop MF herbosomes to resolve the problem of poor bioavailability to enhance the therapeutic potential. METHODS: Successfully prepared MF herbosomes through complexation with phospholipids were characterized by physicochemical, chromatography, spectroscopy (differential scanning calorimetry (DSC), infrared (IR), and nuclear magnetic resonance (NMR)), ex vivo absorption using everted small intestine sac technique and in vivo studies using ethanol inducing hepatotoxicity in albino rats and comparing the results against plain MF. RESULTS: Ex vivo study showed significant increased absorption of MF from prepared MF herbosomes as compared to plain MF. The hepatoprotective potential of MF herbosomes evaluated by in vivo study revealed significantly decreased levels of serum glutamate oxaloacetate transminase (SGOT), serum glutamate pyruvate transminase (SGPT), total bilirubin, and alkaline phosphatase (ALP) in MF herbosomes as compared to plain MF. MF herbosomes also showed significantly decreased level of malonyl dehydrogenase along with increased levels of reduced glutathione, superoxide dismutase (SOD) and catalase as compared to plain MF which was also comparable to the standard drug, silymarin (SL). CONCLUSION: The above mentioned results showed that hepatoprotective and antioxidant potency of MF enhanced due to the preparation of its herbosomes.


Assuntos
Antioxidantes/uso terapêutico , Suplementos Nutricionais , Absorção Intestinal , Hepatopatias Alcoólicas/prevenção & controle , Fígado/fisiopatologia , Fosfatidilcolinas/uso terapêutico , Xantonas/uso terapêutico , Animais , Antioxidantes/química , Antioxidantes/metabolismo , Biomarcadores , Fenômenos Químicos , Feminino , Técnicas In Vitro , Fígado/patologia , Hepatopatias Alcoólicas/sangue , Hepatopatias Alcoólicas/patologia , Hepatopatias Alcoólicas/fisiopatologia , Masculino , Ayurveda , Micelas , Fosfatidilcolinas/química , Fosfatidilcolinas/metabolismo , Substâncias Protetoras/química , Substâncias Protetoras/metabolismo , Substâncias Protetoras/uso terapêutico , Ratos , Ratos Wistar , Sequestrantes/química , Sequestrantes/metabolismo , Sequestrantes/uso terapêutico , Solubilidade , Glycine max/química , Xantonas/química , Xantonas/metabolismo
2.
J Enzyme Inhib Med Chem ; 25(4): 492-501, 2010 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-19857044

RESUMO

Two novel series of oxadiazole and oxadiazoline analogs possessing an indole nucleus were synthesized for their potential anti-inflammatory activity. The structures of the compounds were elucidated by elemental and spectral (IR, (1)H-NMR, (13)C-NMR, and MS) analysis. Most of the test compounds demonstrated appreciable anti-inflammatory activities. The anti-inflammatory activity of oxadiazoles at doses of 100 mg/kg was shown by their ability to provide 27-66%, 14-32%, and 20-51%. protection against carrageenan-induced rat paw edema, moist cotton pellet-induced, and dry cotton pellet-induced granuloma, respectively. On the other hand, the anti-inflammatory properties of oxadiazolines at doses of 100 mg/kg were reflected by their ability to provide 20-56%, 11-26%, and 25-47% protection against carrageenan-induced rat paw edema, moist cotton pellet-induced, and dry cotton pellet-induced granuloma, respectively. The ulcerogenic potential of the compounds was determined. Structure-activity relationships among synthesized compounds were also established.


Assuntos
Anti-Inflamatórios/síntese química , Oxidiazóis/síntese química , Animais , Anti-Inflamatórios/farmacologia , Desenho de Fármacos , Edema/induzido quimicamente , Edema/tratamento farmacológico , Edema/prevenção & controle , Espectroscopia de Ressonância Magnética , Espectrometria de Massas , Oxidiazóis/farmacologia , Ratos , Relação Estrutura-Atividade , Úlcera/induzido quimicamente
SELEÇÃO DE REFERÊNCIAS
DETALHE DA PESQUISA
...