A Systematic Review of the Distribution and Prevalence of Viruses Detected in the Peromyscus maniculatus Species Complex (Rodentia: Cricetidae).

The North American Deermouse, Peromyscus maniculatus, is one of the most widespread and abundant mammals on the continent. It is of public health interest as a known host of several viruses that are transmissible to humans and can cause illness, including the acute respiratory disease Hantavirus Pulmonary Syndrome (HPS). However, recent taxonomic studies indicate that P. maniculatus is a complex of multiple species, raising questions about how to identify and interpret three decades of hantavirus monitoring data. We conducted a systematic review investigating the prevalence and spatial distribution of viral taxa detected in wild populations allocated to P. maniculatus. From the 46 relevant studies published from 2000 to 2022, we extracted and analyzed spatial occurrence data to calculate weighted populational prevalences for hantaviruses. We found that detection efforts have been concentrated in the Western United States and Mexico with a focus on the spread of Sin Nombre virus, the primary causative agent of HPS. There are significant gaps in the existing literature both geographically and in regard to the types of hantaviruses being sampled. These results are significantly impacted by a recent taxonomic split of P. maniculatus into four species, which results in the relabeling of 92% of hantavirus observations. Considering the uncertain, and likely multiple, phylogenetic histories of these viral hosts should be a key emphasis of future modeling efforts.

Barriers to mental health service utilization among Arab society in Israel: Perspectives from service providers.

This study attempted to identify the barriers to the utilization of mental health services among the Arab society in Israel, as perceived by professionals working with this population. Twenty-seven therapists from community mental health services participated in structured in-depth interviews with at least 5 years of experience. Five main types of barriers to the utilization of mental health services were discovered: barriers related to attitudes and perceptions regarding mental disorders and their treatment, low literacy in the field of mental health, exposure and stigma, family characteristics and cultural values, and instrumental barriers. Flexibility and sensitivity to the socio-cultural context of the target population while allocating resources to create equality in access to mental health care may increase the utilization of mental health services in a traditional society such as the Arab society in Israel.

Clean energy transition and climate vulnerabilities: A comparative analysis of European and non-European developed countries.

Currently, the world faces an existential threat of climate change, and every government across the globe is trying to come up with strategies to tackle the severity of climate change in every way possible. To this end, the use of clean energy rather than fossil fuel energy sources is critical, as it can reduce greenhouse gas emissions and pave the way for carbon neutrality. This study examines the impact of the energy cleanability gap on four different climate vulnerabilities, such as ecosystem, food, health, and housing vulnerabilities, considering 47 European and non-European high-income countries. The study considers samples from 2002 to 2019. This study precedes the empirical analysis in the context of a quadratic relationship between the energy cleanability gap and climate vulnerability. The study uses system-generalized methods of the moment as the main technique, while panel quantile regression is a robustness analysis. Fixed effect and random effect models have also been incorporated. The study finds that the energy cleanability gap and all four climate vulnerabilities demonstrate a U-shaped relationship in both European and non-European countries, implying that when the energy cleanability gap increases, climate vulnerability decreases, but after reaching a certain threshold, it starts to increase. Development expenditure is found to be negatively affecting food and health vulnerabilities in European nations, while it increases food vulnerability and decreases health vulnerability in non-European nations. Regarding industrialization's impact on climate vulnerabilities, the study finds opposite effects for the European and non-European economies. On the other hand, for both groups, trade openness decreases climate vulnerabilities. Based on these results, the study recommends speeding up the energy transition process from fossil fuel energy resources towards clean energy resources to obtain carbon neutrality in both European and non-European groups.

From brown to green: are Asian economies on the right path? Assessing the role of green innovations and geopolitical risk on environmental quality.

Preserving the sustainability of the natural environment has emerged as a critical focus on policy agendas worldwide. Therefore, this study examines the relationship between environmental quality and key determinants, focusing on geopolitical risk (GPR), green innovations (GI), economic growth, FDI, renewable energy consumption, and urbanization. Dataset is used for the time period of 1990-2020 across selected Asian economies including China, India, Japan, Malaysia, and South Korea. Using load capacity factor (LCF) as a comprehensive proxy for environmental quality, the research utilizes panel quantile regression (QR) to provide empirical outcomes. Results of panel QR method reveal a negative impact of economic growth and GPR on LCF. On the other hand, green innovation, FDI, and renewable energy are found as supportive factors to boost environmental quality. In addition, urbanization also shows positive linkage with LCF. The application of Fully Modified Ordinary Least Squares (FMOLS) and Dynamic Ordinary Least Squares (DOLS) further validates the robustness of the findings. Adoption of green innovations, practicing sustainable growth patterns, transition toward cleaner energy practices, and integrated urban planning are advocated to enhance environmental quality among Asian nations. Based on empirical findings study suggests comprehensive policy measures that can help in achieving sustainable development goals (SDGs) including SDG-7 (energy efficiency), SDG-8 (sustainable economic growth), SDG-11 (sustainable cities), and SDG-13 (climate action) among Asian countries.

Can clean energy and technology address environmental sustainability in G7 under the pre-set of human development?

Climate change presents challenges for both industrialized and developing nations, primarily due to insufficient pollution control. Increased fossil fuel usage escalates pollution levels, emphasizing the need to integrate more renewable energy into the energy mix, particularly to reduce carbon emissions. Consequently, public investment in renewable energy becomes pivotal to enhance the necessary technology for green energy production. Human development and technological progress play a crucial role in advancing green energy and ensuring environmental sustainability. This study addresses whether clean energy and technology can foster ecological sustainability in the G7 while considering human development. Findings emphasize the significance of public investments in renewable energy projects, technical innovation, and human development. Such investments are essential for augmenting renewable energy shares and lowering carbon emissions in the long run. The study proposes relevant policies to help G7 nations achieve United Nations Sustainable Development Goals related to green energy transition (SDG-7), environmental sustainability (SDG-13), and innovation (SDG-9). In essence, prioritizing renewable energy investment and innovation is imperative for sustainable development.

Exploring the Bereavement Experience Due to COVID-19 Death Among Arabs in Israel.

This study examined the experience of bereavement because of COVID-19 among the Arab minority in Israel, based on the two-track model of grief, using a qualitative approach. The data was collected in an in-depth interview with 34 participants representing the three religions in the Arab population in Israel, approximately 1 year after the loss occurred. The findings revealed that most participants reported returning to their previous function almost completely, exclusively in the field of work. However, they reported decreased social functioning and feelings of loneliness and sadness, and some reported manifestations of active and traumatic grief. Some findings may create a false impression that the mourners have gone through the loss process and returned to normal. However, the current study's findings refute this conclusion, which requires appropriate treatment from health professionals.

Initiating Treatment with Low Fluorouracil Dose and Titrating According to Blood Levels in Patients Treated with a 46-Hour Continuous Infusion.

INTRODUCTION: Fluorouracil (5-FU) pharmacokinetics are variable, leading to a risk of toxicity in some patients and underdosing in others. Therapeutic drug monitoring of 5-FU was shown to reduce toxicity and increase efficacy. This study assessed the clinical utility of starting treatment with 70-80% of BSA calculated dose and titrating according to 5-FU blood levels and toxicity. METHODS: A retrospective analysis of a prospectively collected database of 126 patients treated with regimens containing 5-FU bolus and continuous infusion for 46 h for whom the 5-FU blood level was collected at least once. Response,and date of progression, and death were collected for patients with colon and pancreatic cancer. RESULTS: In multivariate analysis, 5-FU blood levels were correlated with 5-FU dose and with age, albeit a small effect size (coefficient = 0.007). Of patients with colon cancer treated with an initial lower 5-FU dose, 18% had a therapeutic 5-FU blood level. The median survival was similar in patients with metastatic colon cancer treated with lower doses and those treated with a full dose. Of patients with pancreatic cancer treated with lower doses, 40% had therapeutic blood levels. The median survival was 13 months in patients with metastatic pancreatic cancer treated with lower 5-FU doses. CONCLUSION: Starting treatment with low 5-FU dose was associated with patient survival comparable to other published data, and a sizeable percentage of patients had therapeutic blood levels. This approach can be considered, especially in elderly and frail patients.

Construction and Piloting of Attitude Towards Research Participation Scale for University Students.

INTRODUCTION: Attitude toward participation in the research plays an important role in the quality of any research. Therefore, researchers aimed at construction and piloting of scale to measure attitude toward research participation for university students. METHOD AND RESULTS: In Study I, an initial pool of items was generated on the basis of literature review, semi-structured interviews and expert opinions. After ensuring content validity and finalizing items with the help of experts, the scale was applied on a sample of 426 university students including both men (n = 114) and women (n = 312) with age range of 17-30. Exploratory factor analysis revealed the two factor structure was with 60.33% cumulative variance. The factors revealed were positive attitude and negative attitude toward research with alpha reliability of 0.84 for positive attitude while 0.76 for negative attitude. In Study II, confirmatory factor analysis revealed excellent model fit indices with two factor structure. Study III was meant to provide evidence of construct validity. Positive correlation showed exploration and curiosity with positive attitude toward research and negative correlation of exploration and curiosity with negative attitude toward research participation provided strong evidence for convergent validity. While non-significant correlation of attitude toward research with religiosity confirmed the divergent validity of the scale. CONCLUSION: Findings of the study revealed that Attitude Toward Research Participation Scale is a valid and reliable measure. It can be used for university students to measure their attitude toward research.

Circulatory TGF-beta1 is significantly higher in early stage of pulmonary sarcoidosis.

Introduction: The pathogenesis of pulmonary fibrosis in sarcoidosis is not known. We hypothesized that higher levels of circulatory growth factors are present in early stages of pulmonary sarcoidosis and may be associated with pulmonary fibrosis. Methods: Age and sex-matched subjects with sarcoidosis stage 0-1 (n=18), stage 4-5 (n=13) and healthy controls (n=5) had their serum TGF-ß1, FGF, and VEGF levels measured as well as their gene expressions determined in peripheral blood mononuclear cells. Results: TGF-ß1 levels were significantly higher in patients with stage 0-1 sarcoidosis compared with normal healthy control patients (25,488 vs. 13800 pg/ml, P=0.05). Patients with sarcoidosis stage 4 had a 1.3-fold higher peripheral blood mononuclear cells (PBMC) gene expression of TGF-ß1 compared with subjects at stage 0-1 (P= 0.041). The serum levels of FGF, and VEGF had a trend towards higher levels in sarcoidosis subjects compared to normal controls. Conclusion: These results suggest that cell growth factors levels are high in early stages of sarcoidosis. These findings should be validated in larger studies. (Sarcoidosis Vasc Diffuse Lung Dis 2018; 35: 213-217).