Highly active dinuclear cobalt complexes for solvent-free cycloaddition of CO2 to epoxides at ambient pressure.

Dinuclear Co-based catalysts are used for the coupling reaction of epoxides and CO2 in the presence of a cocatalyst. The easily recyclable catalysts efficiently complete the coupling of CO2 with various epoxides into industrially important cyclic carbonates at low catalyst loading and displayed high catalytic activity under relatively low CO2 pressure and solvent-free conditions. The maximum TON (168 600) and TOF (3333 h-1) obtained in this work are the highest among the reported Co-complexes.

Molecular Docking, Computational, and Antithrombotic Studies of Novel 1,3,4-Oxadiazole Derivatives.

A new series of 1,3,4-oxadiazoles derivatives was synthesized, characterized, and evaluated for their in vitro and in vivo anti-thrombotic activity. Compounds (3a⁻3i) exhibited significant clot lysis with respect to reference drug streptokinase (30,000 IU), and enhanced clotting time (CT) values (130⁻342 s) than heparin (110 s). High affinity towards 1NFY with greater docking score was observed for the compounds (3a, 3i, 3e, 3d, and 3h) than the control ligand RPR200095. In addition, impressive inhibitory potential against factor Xa (F-Xa) was observed with higher docking scores (5612⁻6270) with Atomic Contact Energy (ACE) values (-189.68 to -352.28 kcal/mol) than the control ligand RPR200095 (Docking score 5192; ACE -197.81 kcal/mol). In vitro, in vivo, and in silico results proposed that these newly synthesized compounds might be used as anticoagulant agents.