RESUMO
The title compound, C 11H12N4O2,was prepared via the transformation of sodium 4-acetyl-1-phenyl-1H-[1.2.3]triazolate under the action of meth-oxy-amine hydro-chloride. The dihedral angle between the triazole and phenyl rings is 25.12â (16)° and the C atom of the meth-oxy group deviates from the triazole plane by 0.894â (4)Å. The conformation of the CONHR-group is consolodated by an intra-molecular N-Hâ¯N hydrogen bond to an N-atom of the triazole ring, which closes an S(5) ring. In the crystal, weak N-Hâ¯N hydrogen bonds link the mol-ecules into C(6) [010] chains.
RESUMO
A general approach has been developed for the one-pot synthesis of 3,4,5-trisubstituted 1,2,4-triazoles from secondary amides and hydrazides via triflic anhydride activation followed by microwave-induced cyclodehydration. In addition, the 1,2,4-triazole moiety is shown to be a useful directing group for Ru-catalyzed C-H arylation. Access to 1,2,4-triazolophenanthridine can be achieved from the reaction products using a Pd-catalyzed intramolecular C-H functionalization reaction.