[Protective platelet features in fibrocavernous tuberculosis]. / Zashchitnye osobennosti trombotsitov pri fibrozno-kavernoznom tuberkuleze.

Light and electron microscopy was used to study platelets in acute and chronic pulmonary tuberculosis. The structure of platelets was demonstrated to be altered depending on the pattern of a tuberculous process. The ratio of alpha-granules, dense glanules, mitochondria, and lysosomes was also changed. The role of platelets in an immunological process was studied. The redistribution of glanules in the platelets finds its new reflection in the light of the psycho- and neutropic actions of the granules contained.

Protective characteristics of platelets in tuberculosis.

We demonstrated specific changes in platelet structure in different types of tuberculous process, in particular, shift in the proportion between alpha-granules, dense granules, different disorders in the mitochondrial and lysosomal apparatus, etc. The role of platelets in immune process is studied. Redistribution of alpha-granules in platelets finds a new interpretation in light of psycho- and neurotropic effects of their contents. Adhesion and aggregation processes and granule release from platelets are regulated by the content of serotonin and cyclic nucleotides in these cells.

Erythrocyte structure and function in fibrocavernous tuberculosis and tuberculous meningitis.

Erythrocyte disintegration processes are more pronounced in meningeal tuberculosis, which is associated with a shift in isoform spectrum of hemoglobin, catalase inhibition, and a sharp aggravation of lactoacidosis. The severity of erythrocyte disintegration cannot serve as a criterion of differential diagnosis of tuberculosis severity.

[Immunologic characteristics of bronchial asthma developing as a result of influenza infection]. / Immunologicheskaia kharakteristika bronkhial'noi astmy, razvivshesia v rezul'tate grippoznoi infektsii.

The patients with atopic and non-atopic bronchial asthma (BA) provoked by influenzal infection and subjects with influenza were examined for immunity by detection of lymphocyte populations and subpopulations with monoclonal antibodies, by study of the cell-mediated immunity with lymphocyte blast transformation, and by investigation of total and allergen-specific (antiinfluenzal) IgE. It has been established that atopic bronchial asthma formed with influenza participation is a typical allergic disease based on allergo-immunologic disorders characteristic of atopic diseases. Non-atopic bronchial asthma provoked by influenza is mainly formed as a result of secondary immune disorders more characteristic of an infection-dependent pathology. The unfavourable effect of influenzal infection on IgE regulation entails excess production of serum IgE and formation of antiinfluenzal reagins in patients with atopic diseases.

[Rapid immunoenzyme diagnosis of influenza in patients with various allergoses and bronchial asthma]. / Immunofermentnaia ékspress-diagnostika grippa u bol'nykh razlichnymi allergozami i bronkhial'noi astmoi.

In an investigation carried out in the allergological clinic of the Tbilisi State Medical Institute in the period between two outbreaks of influenza, the presence of influenza antigen was determined in nasal washings taken from 127 patients with different allergoses and bronchial asthma by means of the enzyme immuno-assay with the use of the type-specific virion antigen of M1-protein. This method was found to be highly sensitive and to have some advantages over traditional methods used for the diagnosis of influenza. In patients with preasthma and different forms of bronchial asthma elevated susceptibility to influenza infection and its unfavorable influence on the clinical course of these pathological conditions were established.