[Clinical and instrumental characteristics of idiopathic hypertrophic cardiomyopathy and dynamics of echocardiographic indices as affected by beta-adrenergic blockaders]. / Kliniko-instrumental'naia kharakteristika idiopaticheskikh gipertroficheskikh kardiomiopatii i dinamika ékhokardiograficheskikh pokazatelei pod vliianiem beta-adrenergicheskikh blokatorov.

Clinical investigation of 31 patients with idiopathic hypertrophic subaortal stenosis (IHSS) and idiopathic hypertrophic nonobstructive cardiomyopathy (IHNCMP) comprised electro- and phonocardiography, roentgenologic examination and echocardiography. The disease was latent in 3 patients, and ischemic heart disease or rheumatic heart lesion had been diagnosed prior to echocardiography in 26. Asymmetrical hypertrophy and hypokinesia of the upper third of the ventricular septum, narrowed left-ventricular cavity and septum-wise systolic movement of the anterior mitral cusp were findings common to all IHSS patients. The ventricular septum/left-ventricular posterior wall thickness ratio was elevated (1.42 +/- 0.06). In IHNCMP patients, this ratio was within normal range. The results of an acute pharmacologic test with 10 mg intravenous obsidan given to 10 IHSS patients suggested that the obstruction of left-ventricular outflow pathway was somewhat reduced. Prolonged (2 months to 3 years) obsidan treatment was given to 25 patients and was associated with positive effect in terms of improved subjective manifestations of the disease. However, echocardiographic patterns only showed moderate improvement in 9 of the 13 patients who had completed 1-3 years' treatment course.

[Comparison of the results of serial determination of CPK activity with electrocardiographic and clinical data in patients with acute myocardial infarction]. / Sopostavlenie rezul'tatov seriinogo opredeleniia aktivnosti KFK s klinicheskimi i elektrokardiograficheskimi dannymi u bol'nykh ostrym infarktom miokarda.

Correlations between clinical pattern of the disease, electrocardiographic evidence of necrosis from standard leads and the size of infarction expressed in CPK gram-equivalents were examined in 92 patients with acute primary transmural myocardial infarction. In addition, maximum total CPK activity and the pattern of the curve obtained through serial measurements were assessed. The patients were divided in five groups depending on electrocardiographic evidence of necrotic spread, which differed significantly in terms of both enzyme activity and clinical pattern of the disease.

[Serial echocardiographic studies of the function of the left ventricle in acute myocardial infarct]. / Seriinye ékhokardiograficheskie issledovaniia funktsii levogo zheludochka u bol'nykh ostrym infarktom miokarda.

The results of serial echocardiographic examination of 51 patients with primary myocardial infarction are discussed. Echocardiography was performed on the 1st, 3rd, 5th, 7th, 10th, and 20th days of the disease and before discharge. Thirty patients had infarct of the anterior wall and 21 of the posterior wall. The dynamics of left ventricular asynergy, end diastolic index, and volume/pressure coefficient suggested by Corya et al. were studied. The findings were compared with the indices of 20 healthy persons. The indices of regional and general contractile function of the left ventricle grew worse beginning with the first hours of the disease, the changes were most marked on the 3rd day while in cases with a fatal outcome they progressed or did not change. In cases with a fatal outcome they progressed or did not change. In cases with a favourable outcome, the indices improved gradually, first the volume/pressure coefficient and later the end diastolic index. The zones of asynergy disappeared before discharge in only 5 patients. Differences were found depending on the presence and severity of cardiac insufficiency and the localization of the myocardial infarction.