Comparative analysis of blood redox parameters according thyroid function of patients with autoimmune thyroid diseases.

Little is known about various blood parameters of oxidative stress and antioxidant defence patients with various thyroid functional states in autoimmune diseases (ATD). To clarify influence of thyroid metabolic status on blood redox parameters, we performed a complex estimation of patients with ATD (Graves' disease and chronic autoimmune thyroiditis). 50 patients with ATD have been studied: 16 - with hyperthyroidism; 20 - euthyroidism; and 14 - with hypothyroidism. 10 healthy subjects were selected as a control group. In patients with hyperthyroidism has been only observed inverse correlation between ceruloplasmin (CP) and thyroid volume (r= -0,5177, p<0,001); in patients with euthyroidism only inverse correlation between CP and FT4 (r= -0,4970, p<0,001). But in patients with hypothyroidism inverse correlation between Fe(3+)-transferrin and TSH levels (r= -0,6501, p<0,001) and direct correlation between nitric oxide and FT4 (r= 0,5657, p<0,001), and lipid peroxyradicals and FT4 (r= 0,5620, p<0,001) have been established. Thus, according to obtained results oxidative stress occurs at ATD in spite of thyroid status. Our findings about association of the thyroid function and REDOX-system should be considered in the treatment of ATD.

[The status of redox system in patients with chronic autoimmune thyroiditis].

The aim of present investigation was to study redox processes and to establish state of blood oxidative and antioxidant systems in patients with chronic autoimmune thyroiditis (CAT). 19 patients with CAT (2 males, 17 females; mean age 35,3+/-14,8 years) have been randomly investigated, of which 3 patients (15,8%) had hypothyroidism, 11 (57,9%) - euthyroidism and 5 (26,3%) - hyperthyroidism. Control group consisted of 10 practically healthy subjects (2 males, 8 females; mean age 41,1+/-11,7 years). The parameters of blood redox-system were investigated by electron-paramagnetic resonance method (EPR). The value of ceruloplasmin in patients with CAT was significantly higher than in control group (20,0+/-2,0 mm/mg vs. 16,0+/-1,1 mm/mg, p<0,001); EPR-signal of Fe3+ - transferrin in main group was also significantly higher (18,5+/-1,3 mm/mg vs. 22,0+/-0,9 mm/mg, p<0,001); values of nitric oxide in both groups were almost identical. EPR-signals of methemoglobin significantly correlated with thyroid volume (r=0,5421, p=0,016). These changes demonstrate possible relationship between CAT and blood redox system. It should be supposed that the introduction of antioxidant preparations will improve CAT pathogenetic therapy.

[The status of redox system in patients with Graves' disease].

The aim of our investigation was studying the redox processes, the establishment of state of blood oxidative and antioxidant systems in patients with Graves' Disease (GD). 19 with diffuse-toxic goiter have been investigated. Control group included 10 practically healthy subjects. The parameters of blood redox-system were investigated by electron-paramagnetic resonance method (EPR). In GD group hypothyroidism was diagnosed in 7 patients (36,8%), euthyroidism - in 7 patients (36,8%) and hypothyroidism - in 5 (26,3%). The value of ceruloplasmin in main group was significantly higher than in the control (18,6+/-1,3 mm/mg vs. 16,0+/-1,1 mm/mg, p<0,001); EPR-signal of Fe(3+)-transferrin in main group was also significantly higher (19,2+/-1,2 mm/mg vs. 22,0+/-0,9 mm/mg, p<0,001); values of nitric oxide in both groups were almost identical. EPR-signals of Mn(2+) ions significantly correlated with thyroid volume (r=0,5461, p=0,016), NO - with antibodies to thyroglobulin (r=0,5750, p=0,010). These changes demonstrate possible relationship between autoimmune diseases and redox-system.