RESUMO
Centrifugal microfluidics have emerged as a pivotal area of research spanning multiple domains, including medicine and chemistry. Among passive valving strategies, siphon valves have gained prominence due to their inherent simplicity and self-reliance, eliminating the need for external equipment. However, achieving optimal valve performance mandates supplementary elements like surface adjustments or pneumatic pressure. These introduce intricacies such as time-dependent behavior and augmented spatial demands. This research introduces inventive design and manufacturing methodologies to amplify siphon valve functionality. Our proposed innovation situates the siphon microchannel on the external surface of the primary chamber, linked via an inlet. The crux of novelty lies in the adaptable material selection for the microchannel's upper or lower surfaces, allowing the integration of hydrophilic materials such as glass or super hydrophilic coverslips, ensuring a leakage-free operation. Our approach offers a streamlined concept and manufacturing process, ensures consistent time-independent functionality, and accommodates the integration of multiple siphon valves within a solitary chamber, tailored for specific applications. Experimental evaluations validate a robust alignment between acquired data and analytical outcomes based on a modified equation. A customized disc is engineered, featuring four siphon valves meticulously calibrated for hematocrit (HCT) levels spanning from 20% to 50% at 10% intervals. Harnessing these valves yields a substantial surge in plasma separation efficiency, scaling up to 75%. Notably, this performance eclipses traditional single-valve reliant microfluidic methodologies, achieving a purity level exceeding 99% in plasma separation. These findings underscore the auspicious practical applicability of our proposed technique in plasma separation, fostering heightened platelet concentration, and expediting blood sample analysis.
RESUMO
STATEMENT OF PROBLEM: The use of dental implants shorter than 10 mm in length increases the crown-implant ratio. Whether an increased crown-implant ratio affects the survival rate and complications is unclear. PURPOSE: The purpose of this systematic review was to investigate the effect of the crown-implant ratio on the survival rate and complications of implant-supported prostheses. MATERIALS AND METHODS: Five databases (PubMed, MEDLINE, Scopus, Google Scholar, and Cochrane) were electronically and manually searched for longitudinal studies with a follow-up period of 3 years or longer. The study question was "Does the crown-implant ratio affect survival rate and complications of implant-supported prostheses?" The outcomes investigated were implant survival rate, peri-implant bone resorption rate, implant fracture rate, and other technical complications in the implant components. RESULTS: A total of 670 studies were identified from the research in the databases. By applying the inclusion and exclusion criteria to the full texts, 17 articles were included for descriptive analysis. Qualitative data analysis showed that the survival rate of implant-supported prostheses with a crown-implant ratio greater than 2 was 97.2%, and for a ratio lower than 1, it was about 97.6%. Moreover, 9 papers reported that increasing the crown-implant ratio reduced bone resorption, while 8 other studies reported no significant association between the increase in the crown-implant ratio and bone resorption. CONCLUSIONS: No significant relationship was found between the crown-implant ratio and implant survival rate. However, increasing the crown-implant ratio is likely to decrease bone loss around the implant. Information was insufficient to analyze the relationship between the crown-implant ratio and technical complications in implant-supported prostheses.
