[The prevention of the hypercoagulation syndrome during the combined treatment of lung cancer patients using artificial hyperglycemia]. / Profilaktika giperkoaguliatsionnogo sindroma pri kombinirovannom lechenii bol'nykh rakom legkogo s ispol'zovaniem iskusstvennoi giperglikemii.

Status of hemostasis system and occurrence of postoperative thromboembolic complications were assessed in 246 lung cancer patients in whom combined treatment included artificial hyperglycemia. The latter condition contributed to higher blood coagulability resulting in lung artery thromboembolism in some cases. Administration of a combination of heparin, curantil and nicotinic acid was followed by a decrease in blood coagulability, increase in anticoagulation function, decrease in platelet aggregability, activation of fibrinolysis and regression of biochemical signs of DIC syndrome thereby assuring a drop in the occurrence of thromboembolic complications.

[Survival of patients with lung cancer in combined treatment using hyperglycemia]. / Vyzhivaemost' bol'nykh rakom legkogo pri kombinirovannom lechenii s ispol'zovaniem giperglikemii.

The paper is concerned with the results of a randomized study of combined therapy of lung cancer patients including large field radiotherapy (total irradiation of 20 Gy, daily fractionation of 4 Gy) and induced hyperglycemia (22-23 mmol/l). The use of new variants of combined therapy was shown to increase significantly the survival of patients, however therapeutic efficacy was different depending on the time of hyperglycemia: whether it was used before radiotherapy sessions or after their discontinuation.

[Effects of induced hyperglycemia on the activity of pancreatic and gastrointestinal secretion of hormones in oncologic patients]. / Vliianie iskusstvennoi giperglikemii na aktivnost' pankreaticheskoi i gastrointestinal'noi sekretsii gormonov u onkologicheskikh bol'nykh.

Artificial hyperglycemia (AHG) used in the cancer treatment considerably increases the insulin and S-peptide content in blood, decreases the glucagon concentration and tissue glucose tolerance. The changes are reversible, have a functional character, that indicates the absence of a disbalance in hormonal mechanisms of carbohydrate metabolism control as well as marked disorders of the pancreas function. In order to achieve a wider range of indications for using AHG in complex schemes of the cancer treatment, it is necessary to take measures on optimization of the carbohydrate metabolism state which should be controlled by the suggested complex of laboratory tests.

[Morphometry of squamous cell cancer of the lung after radiation therapy combined with hyperglycemia]. / Morfometriia ploskokletochnogo raka legkogo posle luchevoi terapii v sochetanii s giperglikemiei.

The authors analysed morphological changes and provided morphological assessment of the parenchyma, stroma, vessels and necrosis in the squamous cell lung carcinoma tissue of 40 patients without preliminary irradiation, 40 patients after gamma-beam therapy and 49 patients after radiotherapy combined with induced hyperglycemia (IH). The total focal dosage was 20 Gy (5 fractions during a week). In 25 patients IH was followed by irradiation and in 24 patients it followed irradiation. Operation was performed on the 7-8th day after therapy was initiated. It was concluded that preoperative gamma-beam therapy followed by IH produced the most noticeable damaging effect on squamous cell lung carcinoma.