[Role of membrane protectors and antioxidants in the process of perfusion and preservation of donor lungs]. / Rol' membranoprotektorov i antioksidantov v protsesse perfuzii i konservatsii donorskikh legkikh.

Comparative study of the effect of four perfusion and preservation solutions on lung function, conducted in experiments on 69 inbred dogs, revealed the following regular features. Euro-Collins and electrolyte solutions cause a marked increase of the capillary-hydrostatic pressure, a significant decrease of colloido-osmotic pressure of the plasma, and, as a result, reduction of the ient between them. This is manifested by edema of the lungs. The use of LPD solution is attended by moderate edema of the lungs in moderately increased capillary hydrostatic pressure and mildly reduced colloido-osmotic pressure of the plasma. Perfusion and preservation of the lungs with the LPD solution, containing membrane protectors and antioxidants, for 12 hours is marked by practically unchanged indices of capillary-hydrostatic pressure, plasma coloido-osmotic pressure, and the gradient between them. Edema of the lungs does not develop in this case.

[The quality of the preservation of lungs using different solutions (an experimental study)]. / Kachestvo konservatsii legkikh razlichnymi rastvorami (éksperimental'noe issledovanie).

Effects of different perfusion conditions and storage of isolated dog lungs on the process of edema development were studied. Sixty-nine mongrel dogs were used in the study. In case of a 15 min perfusion via the pulmonary artery and 12 h storage lung condition depended mainly on the type of solution and addition of protective drugs to this solution. Euro-Collins and low-potassium electrolytic solution markedly increased capillary hydrostatic pressure and drastically reduced plasma colloid-osmotic pressure. As a result filtration coefficient increased and as soon as an hour after reperfusion onset a marked pulmonary edema developed. Use of LPD solution without drugs added for 2.5 h reperfusion was associated with a moderate increase of capillary hydrostatic pressure and negligible decrease of plasma colloid-osmotic pressure. If the reperfusion were longer plasma colloid-osmotic pressure reduced, this leading to development of moderate pulmonary edema. A 15 min lung perfusion via the pulmonary artery and 12 h storage at 1 degree C in LPD solution with membrane protectors and antioxidants was associated with virtually unchanged capillary hydrostatic pressure, plasma colloid-osmotic pressure, and filtration coefficient and, hence, no pulmonary edema.

[Effects of low-frequency ultrasound on tumors cells in experimental animals]. / O vliianii ul'trazvuka nizkoi chastoty na kletki opukholi v éksperimente.

The effect of low-frequency ultrasound was studied in different conditions in 197 in vitro experiments according to the histological form of the tumor. It was found that ultrasound with a frequency of 26.6--40.5 kHz, intensity of 2--8 Wt/cm2, and fluctuation amplitude of the end of the smooth cylindrical instrument-wave guide of 60--80 mcm caused destruction of the cells of malignant tumors of humans, whatever the histological form. Experiments with transplanted tumors--Zaidel's ascitic hematoma and sarcoma M-l of rats (202 rats) showed that after transplantation of a tumor cell suspension exposed to sonic waves for 5--7 minutes a tumor does not develop in highly susceptible experimental animals.