[FGF23 tumor induced osteomalacia with localization of neoplasm in the tympanic cavity]. / FRF23-indutsirovannaya osteomalyatsiya opukholevogo geneza s lokalizatsiei novoobrazovaniya v barabannoi polosti.

Tumor induced osteomalacia is a rare paraneoplastic syndrome caused by mesenchymal tumors that secrete fibroblast growth factor 23 (FGF23). Patients complain of progressive bone pain, muscle weakness and brittle fractures. Delayed diagnosis of osteomalacia caused by a tumor is often found in clinical practice. When verifying the exact localization of the neoplasm, radical removal within healthy tissues is recommended. The article considers a clinical example of FGF23 tumor induced osteomalacia with localization of neoplasm in the tympanic cavity.

[The innovative surgical technologies for the treatment of chronic suppurative otitis media]. / Innovatsionnye khirurgicheskie tekhnologii lecheniia khronicheskogo gnoinogo srednego otita.

Chronic suppurative otitis media (CSOM) is a most common pathology among all other ENT diseases that accounts for approximately 48% of the total number of their cases. Modern surgery witnesses the advent of new methods for the management of these conditions in parallel with the modification of the known techniques intended to improve the post-operative outcomes of the treatment and rehabilitation of the patients. The objective of the present study was to enhance the effectiveness of the surgical treatment of the patients presenting with chronic suppurative otitis media by making use of the relevant navigation systems. A total of 29 patients presenting with CSOM underwent the surgical intervention on 31 ears. The open variant of sanation surgery on the middle ear was chosen including the hearing-improving component or without it depending on the extension of the pathological process under control of the Navigation Panel Unit ('Karl Storz', Germany) and KICK ('BrainLab', Gerfmany) navigation systems. Special emphasis is placed on the selected peculiar features of their application. It was shown that the use of the aforementioned navigation systems considerably improved the field of vision and the orientation in all compartments of the middle ear which made it possible to prevent the potential intra-operative (in all 31 cases) and post-operative complications. None of the patients suffered complications within 2 months after the onset of the treatment. The microotoscopice examination revealed the signs of the inflammatory process in three patients 6 months after surgery. Only one patient was suspected to have a recurrent cholesteatoma 12 months after the surgical intervention. The second operation included the removal of the cholesteatoma pearl, revision of the post-operative cavity, and re-tympanoplasty. The most important positive effects expected from the application of the navigation systems include the improved orientation in three dimensions that gives assurance to the surgeon thereby making his actions more accurate and precise and the reduction of the duration of the surgical intervention.

[Local antibacterial therapy for the inflammatory diseases of the external and middle ear].

The objective of the present study was to estimate the efficacy and safety of candibioic designed for the treatment of the patients presenting with diffuse otitis externa and chronic otitis media. The open randomized trial included 40 patients with diffuse otitis externa and 40 ones with chronic otitis media who had undergone a surgical sanitation procedure. Their standard clinical and otorhinolaryngological examination was supplemented by the characteristic of clinical symptoms and personal complaints using the 10-score scale. The composite preparation candibiotic was found to be equally effective for the treatment of both diffuse otitis externa and chronic otitis media. The results of the study give reason to recommend the use of candibiotic as an efficacious and safe drug for the treatment of these conditions.