Assuntos
Penicilinas/toxicidade , Poluição Química da Água/prevenção & controle , Água/normas , Animais , Relação Dose-Resposta a Droga , Cobaias , Imunidade Inata/efeitos dos fármacos , Intestinos/efeitos dos fármacos , Intestinos/microbiologia , Dose Letal Mediana , Camundongos , Ratos , Fatores de Tempo , U.R.S.S.RESUMO
Immunological examination of women occupied in production of penicillin revealed a decrease in the phagocytic activity of the blood neutrophiles and the bactericidal properties of the skin, an increase in the quantitative composition of the autoflora of the skin and changes in its biochemical properties. Correlation between the changes in the values of the natural non-specific immunity as dependent on the level of the contact with the antibiotic was shown.
Assuntos
Indústria Farmacêutica , Imunidade/efeitos dos fármacos , Penicilinas/farmacologia , Adulto , Exposição Ambiental , Feminino , Humanos , Moscou , Neutrófilos/efeitos dos fármacos , Fagocitose/efeitos dos fármacos , Pele/efeitos dos fármacos , Pele/imunologia , Pele/microbiologia , Fatores de TempoRESUMO
A total of 90 persons being in contact with aminoglycosides and penicillin were examined. It was found that such a contact resulted in dysbacteriosis of the intestine. The culture of Coli bacteria isolated from the persons had a low fermentative activity and lost their mobility. Bificol, a biological preparation proved to be promising in the treatment of persons with dysfunction of the intestine against the background of dysbacteriosis.
Assuntos
Aminoglicosídeos/farmacologia , Enterobacteriaceae/efeitos dos fármacos , Intestinos/microbiologia , Penicilinas/farmacologia , Indústria Química , Enterobacteriaceae/isolamento & purificação , Etilsuccinato de Eritromicina/farmacologia , Humanos , Canamicina/farmacologia , Neomicina/farmacologiaRESUMO
Toxocity of ampicillin trihydrate was studied in acute and chronic experiments. It was shown that the antibiotic had low acute toxicity, did not cumulate and had no skin-irritating effect. On its inhalation in concentrations of 5 mg/m3 for 4 months, ampicillin induced allergization of albino rats, decreased their immunity. The general toxic effect of the drug was slightly pronounced. Ampicillin in a concentration of 0.1 mg/m3 induced tension of the immunological reactivity of the organism. The maximum permissible concentration (MPC) of ampicillin in the working premises equal to 0.1 mg/m3 is recommended. Mark "Allergen" is necessary.