Assuntos
Osso e Ossos/diagnóstico por imagem , Fístula Intestinal/diagnóstico por imagem , Fístula Intestinal/etiologia , Radioterapia/efeitos adversos , Fístula da Bexiga Urinária/diagnóstico por imagem , Fístula da Bexiga Urinária/etiologia , Idoso de 80 Anos ou mais , Doenças do Ceco/diagnóstico por imagem , Doenças do Ceco/etiologia , Humanos , Masculino , Neoplasias da Próstata/radioterapia , CintilografiaRESUMO
UNLABELLED: (18)F-FDG uptake in the thymus, mainly related to hyperplasia after chemotherapy, has been described. Thymic uptake can challenge the accurate assessment of cancer patients by (18)F-FDG imaging. The present study defines the incidence, patterns, and intensity of thymic (18)F-FDG uptake in relationship to age and time after treatment in a large cohort of patients. METHODS: A total of 559 consecutive (18)F-FDG PET/CT studies in 160 patients (86 men, 74 women; age, 3-40 y) performed at baseline, during treatment, at the end of treatment, and during follow-up were retrospectively reviewed. PET/CT studies were assessed for the presence or absence (T+ or T-, respectively), pattern, and intensity (SUVmax) of increased (18)F-FDG uptake in the anterior mediastinum, localized by the CT component to the thymus. The overall incidence of (18)F-FDG avidity in the thymus in relationship to the patient's age and time after treatment administration were statistically evaluated. RESULTS: There were 137 of 559 T+ studies (25%), with equal sex distribution. T+ studies were found in significantly younger patients (20.6 +/- 9.3 y vs. 27.4 +/- 8.4 y, P < 0.001). Most T+ patients (60%) showed an inverted V pattern of thymic uptake, with additional unilateral mediastinal extension in 24% and focal midline uptake in 16% of studies. T+ studies were encountered in 80% of patients younger than 10 y, compared with 8% of patients in the 31- to 40-y age group. There were 17% T+ studies at baseline, 6% during treatment, 8% at the end of treatment, and 27%-40% during follow-up. The average SUVmax of thymic (18)F-FDG uptake was 3.73 +/- 1.22. CONCLUSION: Thymic (18)F-FDG uptake was found in 28% of the present study population, more frequently after treatment. T+ patients were significantly younger. Thymic uptake was found in 73% of untreated patients up to the age of 13 y and in 8% of patients in the fourth decade of life. Knowledge of this age- and treatment-related incidence of physiologic thymic (18)F-FDG avidity can reduce the number of potential pitfalls in reporting PET/CT studies in cancer patients.
Assuntos
Fluordesoxiglucose F18/farmacocinética , Tomografia por Emissão de Pósitrons/métodos , Compostos Radiofarmacêuticos/metabolismo , Timo/metabolismo , Tomografia Computadorizada por Raios X/métodos , Adolescente , Adulto , Fatores Etários , Criança , Feminino , Humanos , Masculino , Adulto JovemAssuntos
Linfoma de Células B/diagnóstico , Neoplasias da Língua/diagnóstico , Terapia Combinada , Feminino , Isótopos de Gálio , Humanos , Linfoma de Células B/diagnóstico por imagem , Linfoma de Células B/tratamento farmacológico , Linfoma de Células B/radioterapia , Pessoa de Meia-Idade , Cintilografia , Neoplasias da Língua/diagnóstico por imagem , Neoplasias da Língua/tratamento farmacológico , Neoplasias da Língua/radioterapiaRESUMO
Limping is a frequent occurrence in children and may be caused by various conditions, including trauma, inflammation, infection, and malignancy. Nontraumatic avascular necrosis of the tarsal bones should be included in the differential diagnosis. Accumulated data have supported the superiority of bone scans to radiography in the early diagnosis of avascular necrosis. Bone scintigraphy is a useful tool for investigating pain when symptoms, laboratory examinations, and radiography do not point to a specific diagnosis. In the early phase of disease, bone scans may demonstrate decreased tracer uptake (photopenic region), subsequently a hot area is seen during the reparative process. Although magnetic resonance imaging has important implications in the diagnosis of avascular necrosis, bone scintigraphy with its ready availability has a significant role as a primary tool in the evaluation of a limping child.
Assuntos
Osteonecrose/diagnóstico por imagem , Ossos do Tarso/diagnóstico por imagem , Criança , Diagnóstico Diferencial , Humanos , Imageamento por Ressonância Magnética , Masculino , CintilografiaAssuntos
Miosite Ossificante/diagnóstico por imagem , Miosite Ossificante/diagnóstico , Cintilografia/métodos , Neoplasias de Tecidos Moles/diagnóstico por imagem , Neoplasias de Tecidos Moles/diagnóstico , Medronato de Tecnécio Tc 99m , Tecnécio Tc 99m Sestamibi , Criança , Humanos , Deficiência Intelectual/complicações , Masculino , Músculos/metabolismo , Metástase NeoplásicaRESUMO
We report the case of 19-year-old woman with severe hypercalcemia who was evaluated with a bone scan to exclude bone metastases. Increased uptake in both lungs was detected on the bone scan. The patient's final diagnosis was systemic lupus erythematous (SLE). There is no reported pattern of bone scanning in SLE, and diffuse lung uptake has not been reported in these patients.
Assuntos
Hipercalcemia/diagnóstico , Hipercalcemia/metabolismo , Pulmão/diagnóstico por imagem , Pulmão/metabolismo , Lúpus Eritematoso Sistêmico/diagnóstico por imagem , Lúpus Eritematoso Sistêmico/metabolismo , Tecnécio Tc 99m Sestamibi/farmacocinética , Adulto , Neoplasias Ósseas/diagnóstico por imagem , Neoplasias Ósseas/metabolismo , Neoplasias Ósseas/secundário , Diagnóstico Diferencial , Feminino , Humanos , Hipercalcemia/etiologia , Lúpus Eritematoso Sistêmico/complicações , Neoplasias Primárias Desconhecidas/diagnóstico por imagem , Neoplasias Primárias Desconhecidas/metabolismo , Cintilografia , Compostos Radiofarmacêuticos/farmacocinéticaAssuntos
Citratos/farmacocinética , Infecções Oculares/diagnóstico por imagem , Infecções Oculares/metabolismo , Neoplasias Oculares/diagnóstico por imagem , Neoplasias Oculares/metabolismo , Gálio/farmacocinética , Órbita/diagnóstico por imagem , Órbita/metabolismo , Idoso , Idoso de 80 Anos ou mais , Diagnóstico Diferencial , Feminino , Humanos , Cintilografia , Compostos Radiofarmacêuticos/farmacocinéticaRESUMO
A "super scan" pattern detected on bone scintigraphy usually indicates either metabolic bone disease or diffuse metastases. We report a rare case of a 45-year-old man with recurrent episodes of syncope of 10 years' duration in whom bone scintigraphy showed a super scan with an axial skeleton distribution of uptake. Bone marrow biopsy established the diagnosis of systemic mastocytosis. The few reports in the literature of super scans associated with systemic mastocytosis showed diffuse axial and appendicular increased uptake. The present case shows a super scan involving the axial skeleton, which led to the diagnosis of systemic mastocytosis.
Assuntos
Osso e Ossos/diagnóstico por imagem , Mastocitose Sistêmica/diagnóstico por imagem , Síncope/etiologia , Humanos , Masculino , Mastocitose Sistêmica/complicações , Pessoa de Meia-Idade , Cintilografia , Compostos Radiofarmacêuticos , Recidiva , Medronato de Tecnécio Tc 99mRESUMO
A 41-year-old man with known Crohn's disease presented with chest pain and fever. Plain film and CT of the chest were normal, but bone scan and gallium scans showed intense sternal uptake. Surgery revealed staphylococcal osteomyelitis of the sternum. Following appropriate antibiotic treatment, the patient's symptoms resolved and follow-up gallium scans became normal. This is the first report of the association of sternal osteomyelitis and Crohn's disease, although other sites have been described. Sternal osteomyelitis has a high morbidity and the index of suspicion for this condition must be high even in the face of initially negative imaging.