[The pharmacogenetics as integral part of personalized medicine: problems and prospects].

The article considers issues of implementation into clinical practice the principles of 5P medicine in its part of individualization of therapeutic tactics considering genetic characteristics of patients. The analysis of studies concerning influence of allelic variations on metabolism, safety and tolerance of the most often prescribed medicinal preparations was implemented. The main assumptions of pharmacogenomics were considered. Despite broad perspective of applying obtained data in clinical practice, there are a number of unresolved problems related to accessibility of genetic testing to population, ambiguity of approaches to interpretation of obtaining results, ethical issues and legal regulation.

[The comparative analysis of opinions of residents of the northern Caucasus Okrug and persons making decisions concerning issues of healthy municipal planning in its municipalities].

The article presents comparative results of studying opinion of citizens and officials making decisions on modernization of urban environment, about cities conditions. It is established that valuations of citizens and decision makers about urban infrastructure, its quantity and quality, process of cooperation in this area as well as consideration of interests in healthy urban planning differ significantly. The majority of surveyed decision-makers are more satisfied with conditions of their city infrastructure than citizens. The same trend persists in assessing quantity and quality of sport and physical education institutions. On the contrary, environmental situation in municipalities is more likely to suit citizens as compared to decision makers. The decision-makers are more optimistic about intersectorial cooperation in issues of healthy urban planning. The respondents note that issues and interests of health are not sufficiently considered in development and adoption of urban planning decisions in their municipalities. To correct the situation, it is necessary to implement appropriate strategies of healthy urban planning, to determine organizational mechanisms for their implementation in national conditions and to confirm their effectiveness in organizational experiment.

[The evaluation of opinions of residents of the Northern Caucasus Okrug about healthy municipal planning issues].

The article presents the results of examination of opinions of residents of the North Caucasus Federal District concerning healthy urban planning issues. The most residents of large cities are satisfied with infrastructure of their city, while residents of small towns are less satisfied with it. The prioritization of importance of solving various problems of urban life, opinions of residents are not solidary and differ depending on age and place of residence of respondents. For example, construction of playgrounds is a priority for residents of reproductive age from small towns. Only one out of ten of respondents would like to participate in strategy of development of their cities of residence.

[The comparative analysis of level of literacy in issues of health among residents of the Northern Caucasian Federal Okrug].

The article presents the results of comparative analysis of level of health literacy of population of the North Caucasian Federal Okrug of The Russian Federation. The analysis established that the level of functional health literacy of respondents depends on gender, education, standards of living and residence. The lower level of this type of health literacy is established in males, residents of rural areas, individuals with lower standard of living and lower level of education (p<0.05). The interactive level of health literacy is higher in females, urban residents and individuals with higher level of education (p<0.05). The respondents that assessed their level of life as being high demonstrated higher level of interactive health literacy (p<0,05). The number of respondents capable to be oriented in necessary planned medical examinations can be considered as a criterion of critical health literacy. The percentage of respondents oriented in this issue is higher in females, citizens and individuals with higher level of education and life (p<0.05).

[The food habits of women as a factor of development of maternal obesity].

The article presents the results of analysis of diet habits of women in the Stavropol Krai. The study was carried out using single-stage structured interview quantitative survey. The respondent was guaranteed anonymity and the purpose of survey was explained. The questionnaire was targeted to identify diet habits of respondents and to establish their dependence with place of residence, infant feeding schedule, body mass index. The statistical data processing was performed using SPSS v. 24 software. The study demonstrated that majority of respondents feed in a fractional and varied way. The population often pays attention to the storage life of products while buying them. But only 12.5% respondents always control the caloric content of food. The obese women are more attentive to the energy value of food (pm0.001), as well as women feeding infant in a natural way (p=0.002). The respondents consume sweets and regularly add sugar to their drinks. Almost half of women assume that they need to lose weight and 37% tried to lose weight through dieting and 30% of respondents used various medications for weight loss. At that, only 21.2% of respondents were able to achieve the desired weight.

[The carrier attitudes of graduates of medical university].

The article considers issues of professional orientation of future medical students. Their professional and career attitudes were identified. The percentage of students (19%) was determined who already at the stage of education have no plans to work in health care area, partly due to disappointment in their choice of profession. It is established that primary professional career paths for graduates of medical universities are admission to clinical residency (67%) and work in hospital. It is noted that the percentage of graduates wishing to work in private sector of medical services reached 20%. The respondents indicated among causes of problematic employment of graduated professionals lack of experience, lack of knowledge, low wages and overrated expectations of graduates themselves. It is recommended to improve quality of professional selection of applicants, to increase the degree of possession of practical skills and applied knowledge, to ensure increasing of accessibility of clinical residency training and to expand financial support of graduates of medical universities.

[Long-term results of treatment of patients with liver echinococcosis operated by a traditional method and by using high temperature (plasma) technologies].

A comparative analysis of surgical treatment of 160 patients with liver echinococcosis treated by traditional surgical methods and with using plasma technologies followed by a complex assessment of the long-term results has reliably confirmed advantages of operations using the plasma flow. They were followed by less incidence of postoperative complications and recurrences of the disease. It was also confirmed by high quality of life of the contingent observed that was estimated by a specially developed questionnaire.