RESUMO
We studied 107 patients with epilepsy who received monotherapy with valproic acid drugs (58) and carbamazepine (49). The seasonal distribution of number and severity of seizures assessed with the NHS3 scale in dependence of Cmin and Cmax content of antiepileptic drugs carbamazepine and valproates in the serum of patients was estimated. There was a significant increase in the number of seizures and their severity in the cycle spring>autumn>summer>winter. The serum content of carbamazepine and valproates was significantly lower in spring compared to autumn.
Assuntos
Anticonvulsivantes/sangue , Carbamazepina/sangue , Epilepsia/sangue , Epilepsia/tratamento farmacológico , Ácido Valproico/sangue , Ácido Valproico/farmacocinética , Adulto , Anticonvulsivantes/farmacocinética , Anticonvulsivantes/uso terapêutico , Carbamazepina/farmacocinética , Carbamazepina/uso terapêutico , Epilepsia/fisiopatologia , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estações do Ano , Ácido Valproico/uso terapêutico , Adulto JovemRESUMO
A study included 163 patients with focal cryptogenic and symptomatic forms of epilepsy and 47 sex- and age-matched controls. Disturbances of autochronometry in epileptic patients were studied with regard to character, duration, severity, seasonality of seizures and localization of pathological activity in EEG. The elongation of internal count of chronominutes and the ratio of individual chronominute to duration of daylight hours suggest either the approach of a seizure or the early post seizure period, the effect of the completed seizure. The right hemisphere lesion mostly impacts on the patient's perception of time making it longer.
