[Effect of lipoxygenase metabolites of arachidonic acid on the surface charge of the erythrocyte membrane]. / Vliianie lipoksigenaznykh metabolitov arakhidonovoi kisloty na poverkhnostnyi zariad membrany éritrotsitov.

The influence of metabolites of arachidonic acids on the electrophoretic mobility of the rat erythrocytes has been investigated. It is found that they can increase or decrease the surface charge of the erythrocyte membranes.

[Lipoxin B, an enhancing factor of spontaneous platelet aggregation in whole blood]. / Lipoksin B--faktor usileniia spontannoi agregatsii trombotsitov v tsel'noi krovi.

The arachidonic acid metabolites, lipoxin B (5,14,15-trihydroxy-6,8,10,12-eicosatetraenoate) and 5,15-dihydroxy-eicosatetraenoate were shown to possess a marked effect on platelet aggregation and procoagulant activity. Lipoxin B increases and 5,15-dihydroxy-eicosatetraenoate decreases spontaneous platelet aggregation and procoagulant activity when added at various concentrations. The drugs tested were found to have no direct action on blood coagulation.

[Effects of lipoxin B on colony-forming capacity of human peripheral blood mononuclear cells in diffusion chambers]. / Vliianie lipoksina B na kolonieobrazuiushchuiu sposobnost' mononuklearov perifericheskoi krovi cheloveka v usloviiakh diffuzionnoi kamery.

The lipoxin B (5, 14, 15-trihydroxy-6, 8, 10, 12-eicosatetraenoate) obtained by the enzymatic peroxidation of 5, 15-dihydroxy-6, 8, 11, 13-eicosatetraenoate (5, 15-DHETE) with the homogenous rabbit reticulocytes lipoxygenase and purified by HPLC stimulates the proliferation and differentiation of granulocyte-monocyte colony formation units (CFU-GMdc) of human peripheral blood at 3.6 X 10(-9) 3.6 X 10(-8)M in diffusion chamber placed in mouse abdominal cavity. The lipoxin B precursors namely 5,15-DHETE and arachidonic acid had stimulating influence at about 10(-6) and 10(-3)M respectively. The formation of polynuclear cells under the action of the studied lipoxygenase metabolites of the arachidonic acid was shown.