1.
Antibiot Khimioter
; 34(10): 786-92, 1989 Oct.
Artigo
em Russo
| MEDLINE
| ID: mdl-2694992
Assuntos
Diamino Aminoácidos/uso terapêutico , Ácido Diaminopimélico/uso terapêutico , Síndromes de Imunodeficiência/tratamento farmacológico , Leucina/análogos & derivados , Neoplasias Experimentais/tratamento farmacológico , Oligopeptídeos/uso terapêutico , Adjuvantes Imunológicos , Animais , Antineoplásicos , Fenômenos Químicos , Química , Ácido Diaminopimélico/análogos & derivados , Glicina/análogos & derivados , Glicina/uso terapêutico , Cobaias , Síndromes de Imunodeficiência/imunologia , Leucina/uso terapêutico , Camundongos , Peso Molecular , Neoplasias Experimentais/imunologia
2.
Antibiot Med Biotekhnol
; 32(11): 814-6, 1987 Nov.
Artigo
em Russo
| MEDLINE
| ID: mdl-3439786
RESUMO
It was shown that low molecular peptides Nos. 1 and 2 produced by soil bacteria had a pronounced immunostimulating effect. When the preparations were administered at various periods with respect to immunization the number of AFC in the spleen of immunized animals increased 2-4 times. Preparation No. 2 in a dose of 0.5-25 mg/kg increased delayed type hypersensitivity and hemagglutinin levels in blood serum. The maximum effect was observed when the preparation was administered 24 or 48 hours after immunization. The ability to stimulate immunological processes in animals may probably be attributed to the fact that preparations Nos. 1 and 2 are efficient against carcinoma 755 and not toxic in vitro.