[Peculiarities of metabolic characteristics in females of reproductive age with hyperplastic processes of cervix and mammary glands].

The aim of our investigation was the evaluation of character of metabolic disorders in patients with hyperplastic processes of uterine corpus, cervix and mammary glands. 88 patients of reproductive age with several gynaecological complaints have been investigated. 72 patients with hyperplastic processes of endometrium and endocervix (hyperplasia, polyposis), myoma of uterus, fibroadenoms and adenomatosis of mammary glands were selected in main group. Control group consisted of 16 patients without any hyperplastic processes of genital organs. Metabolic syndrome in main group was revealed in 28% of cases, in control--18.8% (chi(2)=3.95, p=0.047); insulin resistance--30.5% and 18.7% (chi(2)=4.01, p=0.046), respectively. In main group in comparison with control group took place the tendency of the increase triglyceride plasma level and the decrease of levels of HDL-cholesterol. b-cell function was significantly increased in patients with hyperplastic processes of uterine corpus and cervix, in subgroup of uterine myoma revealed the tendency. Insulin resistance revealed in patients with hyperplasia of endocervix and pathologies of mammary glands. Our results suggest that metabolic syndrome and its components significantly influences on the formation of hyperplastic processes of uterine corpus, cervix and mammary glands.

[Blood adiponectin and leptin levels in menopausal metabolic syndrome].

The aim of our investigation was the study of blood adiponectin and leptin levels in patients with menopausal metabolic syndrome (MMS) and their correlation with the parameters of MMS features. 40 females with menopause have been investigated. In 38 cases diabetes mellitus type 2 has been registered, and in 2 - impaired glucose tolerance. Mean duration of postmenopausal period was 11,1+/-7,4. Control group consisted of 10 females of postmenopausal age. The blood content of adiponectin and leptin was measured by ELISA. For MMS diagnostics WHO classification (2002) was applied. In basic group MMS was revealed in 37 patients, in control group - in 3 cases (chi(2)=19,53, p<0,001). It was not observed significant difference in blood adiponectin levels of basic and control groups (16,4+/-7,6 vs. 16,3+/-6,1, p=NS), but blood leptin level was significantly higher in study group in comparison with controls (166,7+105,3 vs. 60,3+/-51,0, p<0,001). Significant correlations of blood adiponectin and leptin levels with the parameters of MMS features were observed. Obtained results show that blood adiponectin level in MMS does not differ from the values in control group, although blood leptin level is significantly higher than the one among controls. They significantly correlated with the parameters of MMS features.