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1.
Molecules ; 29(12)2024 Jun 12.
Artigo em Inglês | MEDLINE | ID: mdl-38930871

RESUMO

Synthetic efforts toward complex natural product (NP) scaffolds are useful ones, particularly those aimed at expanding their bioactive chemical space. Here, we utilised an orthogonal cheminformatics-based approach to predict the potential biological activities for a series of synthetic bis-indole alkaloids inspired by elusive sponge-derived NPs, echinosulfone A (1) and echinosulfonic acids A-D (2-5). Our work includes the first synthesis of desulfato-echinosulfonic acid C, an α-hydroxy bis(3'-indolyl) alkaloid (17), and its full NMR characterisation. This synthesis provides corroborating evidence for the structure revision of echinosulfonic acids A-C. Additionally, we demonstrate a robust synthetic strategy toward a diverse range of α-methine bis(3'-indolyl) acids and acetates (11-16) without the need for silica-based purification in either one or two steps. By integrating our synthetic library of bis-indoles with bioactivity data for 2048 marine indole alkaloids (reported up to the end of 2021), we analyzed their overlap with marine natural product chemical diversity. Notably, the C-6 dibrominated α-hydroxy bis(3'-indolyl) and α-methine bis(3'-indolyl) analogues (11, 14, and 17) were found to contain significant overlap with antibacterial C-6 dibrominated marine bis-indoles, guiding our biological evaluation. Validating the results of our cheminformatics analyses, the dibrominated α-methine bis(3'-indolyl) alkaloids (11, 12, 14, and 15) were found to exhibit antibacterial activities against methicillin-sensitive and -resistant Staphylococcus aureus. Further, while investigating other synthetic approaches toward bis-indole alkaloids, 16 incorrectly assigned synthetic α-hydroxy bis(3'-indolyl) alkaloids were identified. After careful analysis of their reported NMR data, and comparison with those obtained for the synthetic bis-indoles reported herein, all of the structures have been revised to α-methine bis(3'-indolyl) alkaloids.


Assuntos
Antibacterianos , Quimioinformática , Alcaloides Indólicos , Antibacterianos/farmacologia , Antibacterianos/química , Antibacterianos/síntese química , Alcaloides Indólicos/química , Alcaloides Indólicos/farmacologia , Alcaloides Indólicos/síntese química , Quimioinformática/métodos , Testes de Sensibilidade Microbiana , Estrutura Molecular , Relação Estrutura-Atividade , Produtos Biológicos/química , Produtos Biológicos/farmacologia , Produtos Biológicos/síntese química
2.
Mar Drugs ; 22(1)2024 Jan 03.
Artigo em Inglês | MEDLINE | ID: mdl-38248658

RESUMO

The known oxygenated polyhalogenated diphenyl ether, 2-(2',4'-dibromophenoxy)-3,5-dibromophenol (1), with previously reported activity in multiple cytotoxicity assays was isolated from the sponge Lamellodysidea sp. and proved to be an amenable scaffold for semisynthetic library generation. The phenol group of 1 was targeted to generate 12 ether analogues in low-to-excellent yields, and the new library was fully characterized by NMR, UV, and MS analyses. The chemical structures for 2, 8, and 9 were additionally determined via single-crystal X-ray diffraction analysis. All natural and semisynthetic compounds were evaluated for their ability to inhibit the growth of DU145, LNCaP, MCF-7, and MDA-MB-231 cancer cell lines. Compound 3 was shown to have near-equivalent activity compared to scaffold 1 in two in vitro assays, and the activity of the compounds with an additional benzyl ring appeared to be reliant on the presence and position of additional halogens.


Assuntos
Antineoplásicos , Éter , Éteres/farmacologia , Etil-Éteres , Éteres Fenílicos/farmacologia , Antineoplásicos/farmacologia
3.
J Nat Prod ; 86(3): 533-540, 2023 03 24.
Artigo em Inglês | MEDLINE | ID: mdl-36787528

RESUMO

The aggregation of the neuronal protein α-synuclein (α-syn) is intrinsically linked to the development and progression of Parkinson's disease (PD). Recently we screened the MeOH extracts from 283 marine invertebrates for α-syn binding activity using an affinity mass spectrometry (MS) binding assay and found that the extract of the ascidian Polycarpa procera displayed activity. A subsequent bioassay-guided purification led to the isolation of one new α-syn aggregation inhibitory butenolide procerolide E (3) and one new α-syn aggregation inhibitory diphenylbutyrate methyl procerolate A (5). Herein we report the structure elucidation of procerolide E (3) and methylprocerolate A (5) and α-syn aggregation inhibitory activity of procerolides C-E (1-3), methyl procerolate A (5) and procerone A (4). We also report the α-syn binding activity of 3-bromo-4-methoxyphenylacetamide (6) and a synthetic butenolide library, which has allowed us to determine α-syn aggregation inhibitory structure-activity relationships for this class of compounds.


Assuntos
Doença de Parkinson , Urocordados , Animais , Humanos , alfa-Sinucleína/metabolismo , Urocordados/metabolismo , Doença de Parkinson/metabolismo
4.
RSC Adv ; 13(7): 4713-4720, 2023 Jan 31.
Artigo em Inglês | MEDLINE | ID: mdl-36760278

RESUMO

To date, 3,3'-bridged dithiophenes with bridges developed from the first period elements (either pristine or oxidised) are non emissive. Benzo[1,2-b:6,5-b']dithiophene-4,5-dione (BDTD) is a typical 3,3' fused-dithiophene with a dione bridge. It is a critical building block for semiconducting materials, and it is non emissive. We serendipitously discovered that by protecting the diketone of BDTD with ethylene glycol, two isomers (BDTD-5 and 6) were obtained and both compounds effectively emit UV light in solution. Their maximum emission (382 and 375 nm for BDTD-5 and 6, respectively) are independent of the type of solvent. Both compounds exhibited fluorescence intensity enhancement in DMF-H2O with the increase of water fraction from 0-90%. BDTD-6 can also effectively emit in its crystalline state with a quantum yield (QY) of 14% and an average fluorescence lifetime of 1.6 ns. X-ray crystallographic analysis indicates that BDTD-6 possesses a 3D C-H…O interaction structure which produced its effective emission in the crystalline state. These two isomers not only have enlarged the emissive members of the 3,3'-fused dithiophene family, but also expand the emission boundary of emitters in this category to the UV area.

5.
Nanomicro Lett ; 14(1): 110, 2022 Apr 19.
Artigo em Inglês | MEDLINE | ID: mdl-35441329

RESUMO

Aqueous zinc-ion batteries (AZIBs) can be one of the most promising electrochemical energy storage devices for being non-flammable, low-cost, and sustainable. However, the challenges of AZIBs, including dendrite growth, hydrogen evolution, corrosion, and passivation of zinc anode during charging and discharging processes, must be overcome to achieve high cycling performance and stability in practical applications. In this work, we utilize a dual-functional organic additive cyclohexanedodecol (CHD) to firstly establish [Zn(H2O)5(CHD)]2+ complex ion in an aqueous Zn electrolyte and secondly build a robust protection layer on the Zn surface to overcome these dilemmas. Systematic experiments and theoretical calculations are carried out to interpret the working mechanism of CHD. At a very low concentration of 0.1 mg mL-1 CHD, long-term reversible Zn plating/stripping could be achieved up to 2200 h at 2 mA cm-2, 1000 h at 5 mA cm-2, and 650 h at 10 mA cm-2 at the fixed capacity of 1 mAh cm-2. When matched with V2O5 cathode, the resultant AZIBs full cell with the CHD-modified electrolyte presents a high capacity of 175 mAh g-1 with the capacity retention of 92% after 2000 cycles under 2 A g-1. Such a performance could enable the commercialization of AZIBs for applications in grid energy storage and industrial energy storage.

6.
Eur J Med Chem ; 235: 114282, 2022 May 05.
Artigo em Inglês | MEDLINE | ID: mdl-35367706

RESUMO

This review covers the literature in the past 15 years on glycosidase inhibitors lacking a basic nitrogen (for example iminosugars/azasugars) with a focus on natural terpenoids, and mono- and polycyclic aromatic hydrocarbons. From quite diverse structures, insight into inhibitor structural features that may be applicable to optimisation of all glycosidase inhibitors including iminosugars are identified.


Assuntos
Glicosídeo Hidrolases , Imino Açúcares , Inibidores Enzimáticos/química , Inibidores Enzimáticos/farmacologia , Imino Açúcares/química , Imino Açúcares/farmacologia
7.
J Nat Prod ; 85(2): 441-452, 2022 02 25.
Artigo em Inglês | MEDLINE | ID: mdl-35050597

RESUMO

Seven new polyaromatic bis-spiroketal-containing butenolides, the prunolides D-I (4-9) and cis-prunolide C (10), a new dibrominated ß-carboline sulfamate named pityriacitrin C (11), alongside the known prunolides A-C (1-3) were isolated from the Australian colonial ascidian Synoicum prunum. The prunolides D-G (4-7) represent the first asymmetrically brominated prunolides, while cis-prunolide C (10) is the first reported with a cis-configuration about the prunolide's bis-spiroketal core. The prunolides displayed binding activities with the Parkinson's disease-implicated amyloid protein α-synuclein in a mass spectrometry binding assay, while the prunolides (1-5 and 10) were found to significantly inhibit the aggregation (>89.0%) of α-synuclein in a ThT amyloid dye assay. The prunolides A-C (1-3) were also tested for inhibition of pSyn aggregate formation in a primary embryonic mouse midbrain dopamine neuron model with prunolide B (2) displaying statistically significant inhibitory activity at 0.5 µM. The antiplasmodial and antibacterial activities of the isolates were also examined with prunolide C (3) displaying only weak activity against the 3D7 parasite strain of Plasmodium falciparum. Our findings reported herein suggest that the prunolides could provide a novel scaffold for the exploration of future therapeutics aimed at inhibiting amyloid protein aggregation and the treatment of numerous neurodegenerative diseases.


Assuntos
Urocordados , alfa-Sinucleína , Animais , Austrália , Carbolinas , Camundongos , Ácidos Sulfônicos , Urocordados/química
8.
ACS Nano ; 14(9): 12016-12026, 2020 Sep 22.
Artigo em Inglês | MEDLINE | ID: mdl-32833424

RESUMO

Redox-active organic cathode materials have drawn growing attention because of the broad availability of raw materials, eco-friendliness, scalable production, and diverse structural flexibility. However, organic materials commonly suffer from fragile stability in organic solvents, poor electrochemical stability in charge/discharge processes, and insufficient electrical conductivity. To address these issues, using Cu(II) salt and benzenehexathiolate (BHT) as the precursors, we synthesized a robust and redox-active 2D metal-organic framework (MOF), [Cu3(C6S6)]n, namely, Cu-BHT. The Cu-BHT MOFs have a highly conjugated structure, affording a high electronic conductivity of 231 S cm-1, which could further be increased upon lithiation in lithium-ion battery (LIB) applications. A reversible four-electron reaction reveals the Li storage mechanism of the Cu-BHT for a theoretical capacity of 236 mAh g-1. The as-prepared Cu-BHT cathode delivers an excellent reversible capacity of 175 mAh g-1 with ultralow capacity deterioration (0.048% per cycle) upon 500 cycles at a high current density of 300 mA g-1. Therefore, we believe this work would provide a practical strategy for the development of high-power energy storage materials.

9.
J Org Chem ; 85(5): 3490-3496, 2020 03 06.
Artigo em Inglês | MEDLINE | ID: mdl-32036659

RESUMO

The structures of the sponge-derived dibrominated bis-indole alkaloids, namely, echinosulfone A (2) and the echinosulfonic acids A to D (9-12), have been revised based upon reanalysis of their NMR spectroscopic and MS spectrometric data, comparison of this data with those reported for structurally related compounds, and based on their common biogenesis. The reinterpreted spectroscopic evidence has been corroborated by the total synthesis of the revised structure of echinosulfone A (2). This was achieved by bis-carbonylation at C-3 of the magnesium salt of 6-bromoindole with triphosgene to afford the new dibrominated bis-indole ketone, bis(6-bromo-1H-indol-3-yl)methanone (3), followed by N-sulfonation of one indole moiety to furnish 6-bromo-3-(6-bromo-1H-indole-3-carbonyl)-1H-indole-1-sulfonate (2). The five marine alkaloids corrected herein each contain an indole sulfamate and are all carbon-bridged dibrominated bis-indoles: echinosulfone A (2) is a di(1H-indol-3-yl)methanone, while the echinosulfonic acids A to D (9-12) are methyl 2,2-bis(1H-indol-3-yl) acetates.


Assuntos
Alcaloides , Alcaloides Indólicos , Espectroscopia de Ressonância Magnética , Estrutura Molecular
10.
J Org Chem ; 84(23): 15226-15235, 2019 12 06.
Artigo em Inglês | MEDLINE | ID: mdl-31657574

RESUMO

The efficient synthesis of a range of structurally related butenolides has been observed while we were exploring the substrate-scope of a Horner-Wadsworth-Emmons (HWE) reaction. While aliphatic aldehydes gave the expected HWE product, aromatic aldehydes furnished butenolides, resulting from the dimerization of the HWE product during desilylation of the initially formed HWE adduct. In addition to isolating butenolides in a high yield, we have also determined precisely when dimerization occurs.

11.
Adv Drug Deliv Rev ; 151-152: 94-129, 2019.
Artigo em Inglês | MEDLINE | ID: mdl-31513827

RESUMO

Many deadly infections are produced by microorganisms capable of sustained survival in macrophages. This reduces exposure to chemadrotherapy, prevents immune detection, and is akin to criminals hiding in police stations. Therefore, the use of glyco-nanoparticles (GNPs) as carriers of therapeutic agents is a burgeoning field. Such an approach can enhance the penetration of drugs into macrophages with specific carbohydrate targeting molecules on the nanocarrier to interact with macrophage lectins. Carbohydrates are natural biological molecules and the key constituents in a large variety of biological events such as cellular communication, infection, inflammation, enzyme trafficking, cellular migration, cancer metastasis and immune functions. The prominent characteristics of carbohydrates including biodegradability, biocompatibility, hydrophilicity and the highly specific interaction of targeting cell-surface receptors support their potential application to drug delivery systems (DDS). This review presents the 21st century development of carbohydrate-based nanocarriers for drug targeting of therapeutic agents for diseases localized in macrophages. The significance of natural carbohydrate-derived nanoparticles (GNPs) as anti-microbial drug carriers is highlighted in several areas of treatment including tuberculosis, salmonellosis, leishmaniasis, candidiasis, and HIV/AIDS.


Assuntos
Anti-Infecciosos/uso terapêutico , Carboidratos/química , Macrófagos/efeitos dos fármacos , Nanopartículas/química , Animais , Anti-Infecciosos/química , Infecções Bacterianas/tratamento farmacológico , Portadores de Fármacos/química , Sistemas de Liberação de Medicamentos , Humanos , Micoses/tratamento farmacológico , Viroses/tratamento farmacológico
12.
Org Biomol Chem ; 17(4): 803-806, 2019 01 23.
Artigo em Inglês | MEDLINE | ID: mdl-30628604

RESUMO

Amidine synthesis by amine addition to nitriles normally requires high temperatures or harsh catalysts. Here, we report that boronate esters can facilitate amidination of proximal amines with moderate heating. With amidines present in a number of drugs and the synthetic handle provided by the boron, this chemistry should find useful applications.

13.
ACS Chem Neurosci ; 9(7): 1530-1551, 2018 07 18.
Artigo em Inglês | MEDLINE | ID: mdl-29782794

RESUMO

Alzheimer's disease (AD) is a progressive neurodegenerative disorder accounting for 60-80% of dementia cases. For many years, AD causality was attributed to amyloid-ß (Aß) aggregated species. Recently, multiple therapies that target Aß aggregation have failed in clinical trials, since Aß aggregation is found in AD and healthy patients. Attention has therefore shifted toward the aggregation of the tau protein as a major driver of AD. Numerous inhibitors of tau-based pathology have recently been developed. Diagnosis of AD has shifted from measuring late stage senile plaques to early stage biomarkers, amyloid-ß and tau monomers and oligomeric assemblies. Synthetic peptides and some derivative structures are being explored for use as theranostic tools as they possess the capacity both to bind the biomarkers and to inhibit their pathological self-assembly. Several studies have demonstrated that O-linked glycoside addition can significantly alter amyloid aggregation kinetics. Furthermore, natural O-glycosylation of amyloid-forming proteins, including amyloid precursor protein (APP), tau, and α-synuclein, promotes alternative nonamyloidogenic processing pathways. As such, glycopeptides and related peptidomimetics are being investigated within the AD field. Here we review advancements made in the last 5 years, as well as the arrival of sugar-based derivatives.


Assuntos
Doença de Alzheimer/tratamento farmacológico , Peptídeos beta-Amiloides/metabolismo , Peptídeos/uso terapêutico , Peptidomiméticos/uso terapêutico , Agregação Patológica de Proteínas/tratamento farmacológico , Proteínas tau/metabolismo , Doença de Alzheimer/metabolismo , Animais , Carboidratos/farmacologia , Carboidratos/uso terapêutico , Humanos , Peptídeos/farmacologia , Peptidomiméticos/farmacologia , Agregação Patológica de Proteínas/metabolismo
14.
Chembiochem ; 19(14): 1476-1481, 2018 Jul 16.
Artigo em Inglês | MEDLINE | ID: mdl-29693771

RESUMO

Glycolipids from Mycobacterium tuberculosis have a profound impact on the innate immune response of the host. Macrophage-inducible C-type lectin (Mincle) is a pattern-recognition receptor that has been shown to bind trehalose dimycolate (TDM) from the mycobacterium and instigate intracellular signalling in the immune cell. There are structural similarities between the structures of TDM and phosphatidyl inositol mannoside (PIM). We thus hypothesized that these latter structures might also modulate an immune response in a similar manner. To test this, we synthesized a series of new mannose derivatives modified with fatty esters at the 6-position and assessed the release of inflammatory cytokines in human U937 macrophages under the induction of lipopolysaccharides (LPS) after glycolipid treatment. The results showed that the amount of two major cytokines-tumour necrosis factor (TNF)-α and interleukin (IL)-6-released from LPS-stimulated U937 cells decreased significantly when compared to a control upon treatment with the prepared glycolipids, thus indicating a reduction in cytokine production by the macrophages.

15.
Mini Rev Med Chem ; 18(10): 812-827, 2018.
Artigo em Inglês | MEDLINE | ID: mdl-28969552

RESUMO

Glycosidases have important anti-cancer, anti-viral and anti-diabetic properties. This review covers the literature in the past 15 years since our initial review in this journal on "neutral" glycosidase inhibitors lacking a basic nitrogen found in iminosugars and azasugars or inhibitors that are neutral by virtue of being "charge-balanced" (zwitterionic). These structurally diverse inhibitors include lactones, lactams, epoxides such as cyclophellitol, and sulfonium ion derivatives of the natural product salacinol. Synthetic efforts toward cyclophillitol, salicinol and derivatives are also highlighted. Importantly, certain metals can inhibit glycosidases and care must be taken to remove residual catalysts from synthetic material to be tested against these enzymes.


Assuntos
Inibidores Enzimáticos/farmacologia , Glicosídeo Hidrolases/antagonistas & inibidores , Animais , Relação Dose-Resposta a Droga , Inibidores Enzimáticos/química , Glicosídeo Hidrolases/metabolismo , Humanos , Estrutura Molecular , Relação Estrutura-Atividade
16.
RSC Adv ; 8(62): 35768-35775, 2018 Oct 15.
Artigo em Inglês | MEDLINE | ID: mdl-35547932

RESUMO

Legionaminic acid is a member of the nonulosonic acids, which are a class of sugars considered to be a virulence factor within a wide variety of pathogenic bacteria. We have developed a synthetic pathway towards C-7 analogues of legionaminic acid starting from Neu5Ac, resulting in the complete synthesis of both legionaminic acid, and its C-7 epimer, from a common precurser. Our approach involves the late-stage introduction of the requisite C-7 nitrogen functionality, thus making our strategy amenable to the introduction of a range of different amide groups at C-7 of legionaminic acid.

17.
Toxins (Basel) ; 8(8)2016 08 09.
Artigo em Inglês | MEDLINE | ID: mdl-27517959

RESUMO

Pyocyanin has recently emerged as an important virulence factor produced by Pseudomonas aeruginosa. The redox-active tricyclic zwitterion has been shown to have a number of potential effects on various organ systems in vitro, including the respiratory, cardiovascular, urological, and central nervous systems. It has been shown that a large number of the effects to these systems are via the formation of reactive oxygen species. The limitations of studies are, to date, focused on the localized effect of the release of pyocyanin (PCN). It has been postulated that, given its chemical properties, PCN is able to readily cross biological membranes, however studies have yet to be undertaken to evaluate this effect. This review highlights the possible manifestations of PCN exposure; however, most studies to date are in vitro. Further high quality in vivo studies are needed to fully assess the physiological manifestations of PCN exposure on the various body systems.


Assuntos
Infecções por Pseudomonas/microbiologia , Pseudomonas aeruginosa/patogenicidade , Piocianina/metabolismo , Fatores de Virulência/metabolismo , Animais , Humanos , Inflamação/imunologia , Inflamação/metabolismo , Inflamação/microbiologia , Mediadores da Inflamação/metabolismo , Estresse Oxidativo , Infecções por Pseudomonas/imunologia , Infecções por Pseudomonas/metabolismo , Pseudomonas aeruginosa/imunologia , Pseudomonas aeruginosa/metabolismo , Piocianina/imunologia , Espécies Reativas de Oxigênio/metabolismo , Fatores de Virulência/imunologia
18.
J Org Chem ; 81(6): 2607-11, 2016 Mar 18.
Artigo em Inglês | MEDLINE | ID: mdl-26907566

RESUMO

The pseudaminic acids are a family of 5,7-diamino-3,5,7,9-tetradeoxynonulosonic acids that are functional components of flagellin and pili proteins within clinically relevant Gram-negative bacteria. Herein, we describe the total synthesis of the most common pseudaminic acid, 5,7-diacetylpseudaminic acid, from N-acetylneuraminic acid. The divergent nature of the route reported here provides a robust and versatile means to access other members of the family, together with analogues, for probing the functional role of the pseudaminic acids and pseudaminic acid derived proteins in the future.


Assuntos
Proteínas de Fímbrias/química , Flagelina/química , Bactérias Gram-Negativas/química , Ácido N-Acetilneuramínico/química , Açúcares Ácidos/química , Açúcares Ácidos/síntese química , Glicosilação , Espectroscopia de Ressonância Magnética
19.
Nano Lett ; 15(7): 4440-7, 2015 Jul 08.
Artigo em Inglês | MEDLINE | ID: mdl-26061529

RESUMO

An environmentally benign, highly conductive, and mechanically strong binder system can overcome the dilemma of low conductivity and insufficient mechanical stability of the electrodes to achieve high performance lithium ion batteries (LIBs) at a low cost and in a sustainable way. In this work, the naturally occurring binder sodium alginate (SA) is functionalized with 3,4-propylenedioxythiophene-2,5-dicarboxylic acid (ProDOT) via a one-step esterification reaction in a cyclohexane/dodecyl benzenesulfonic acid (DBSA)/water microemulsion system, resulting in a multifunctional polymer binder, that is, SA-PProDOT. With the synergetic effects of the functional groups (e.g., carboxyl, hydroxyl, and ester groups), the resultant SA-PProDOT polymer not only maintains the outstanding binding capabilities of sodium alginate but also enhances the mechanical integrity and lithium ion diffusion coefficient in the LiFePO4 (LFP) electrode during the operation of the batteries. Because of the conjugated network of the PProDOT and the lithium doping under the battery environment, the SA-PProDOT becomes conductive and matches the conductivity needed for LiFePO4 LIBs. Without the need of conductive additives such as carbon black, the resultant batteries have achieved the theoretical specific capacity of LiFePO4 cathode (ca. 170 mAh/g) at C/10 and ca. 120 mAh/g at 1C for more than 400 cycles.

20.
Food Res Int ; 76(Pt 3): 626-636, 2015 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-28455046

RESUMO

Coffee is a widely consumed beverage containing numerous biologically active constituents predominantly belonging to the polyphenol and alkaloid classes. It has been established that coffee has a beneficial effect on numerous disease states including depression. A number of prospective and retrospective cohort studies have assessed the effects of coffee consumption on the relative risk of developing major depressive disorder in humans. These studies have identified an inverse relationship between the consumption of caffeinated coffee and the risk of developing depression. Caffeine, chlorogenic acid, ferulic acid and caffeic acid, all important constituents of coffee, have been shown to possess biological activities that highlight a possible mechanistic link to the pathology of depression. This review aims to assess the evidence from the biological evaluation of these constituents of coffee on markers of inflammation associated with depression in in vitro and in vivo models of inflammation, neuroinflammation and depression. The ability of bioactive coffee constituents to modulate the parameters of neuroinflammation has been shown with caffeine having strong antioxidant properties in vitro, chlorogenic acid and caffeic acid having strong anti-inflammatory and antioxidant properties in vitro and ferulic acid having activities in in vivo animal models of depression.

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