Thrombocytopenia among extremely low birth weight neonates: data from a multihospital healthcare system.

OBJECTIVES: Thrombocytopenia is common in neonatal intensive care units (NICU), with 18 to 35% of patients developing this problem before hospital discharge. It might be even more common among extremely low birth weight neonates (ELBW, < or = 1000 g birth weight). However, little is known about thrombocytopenia in the ELBW population. We sought to determine the incidence, timing, causes, platelet transfusions given, and outcomes of thrombocytopenia among ELBW neonates. STUDY DESIGN: We performed a cohort analysis of all 284 ELBW neonates born during 2003 and 2004 cared for in any of the Intermountain Healthcare level III NICUs. RESULTS: Multiple platelet counts were obtained in all 284 (range, 4 to 441 platelet counts/patient). Of the 284, 208 (73%) had one or more platelet counts < or =150 000/microl. Most were detected during the first days of life; 80% were detected during the first week and only 20% were detected thereafter. Thrombcytopenia was more common among the smallest patients; 85% incidence among those < or =800 g, 60% among those 801 to 900 g, and 53% among those 901 to 1000 g. Platelet transfusions were given to 129 of the 208 thrombocytopenic neonates. More than 90% were given prophylactically (the patient was not bleeding). The mortality rate among those that received platelet transfusions was twice that of those that received no platelet transfusions (P < 0.01). In 48% of cases, the cause of the thrombocytopenia went undiagnosed. The most common explanations were being small for gestational age or delivered to a hypertensive mother, DIC, bacterial infection, fungal infection, and necrotizing enterocolitis, respectively. CONCLUSIONS: We observed thrombocytopenia among ELBW neonates at a rate more than twice that reported among the general NICU population. Much remains to be discovered about the etiology and best treatments of thrombocytopenia among ELBW neonates.

Pattern of daily weights among low birth weight neonates in the neonatal intensive care unit: data from a multihospital health-care system.

OBJECTIVES: We sought to generate a contemporary postnatal weight grid for low birth weight (LBW, <2500 g) neonates using actual data, not mathematically derived idealized weight curves. To do this, we collected electronic data from all neonatal intensive care units (NICU) patients weighing 400-2600 g at birth, during 30 consecutive months (January 2003-June 2005) in all four NICU's within a single health system, Intermountain Health Care (IHC). METHODS: A deidentified limited data set was collected from electronic IHC records. Data were limited to the birth weights and all subsequent daily weights, until discharge, death, or transfer to a non-IHC facility. Lines were drawn connecting the exact daily means of body weight for patients in 200 g birth weight groupings, ranging from 400 to 2600 g. We assessed differences in growth patterns predicted by this grid vs three previously published NICU longitudinal weight grids. RESULTS: All recorded weights were electronically extracted for 1813 consecutive patients with dates of birth from January 1, 2003 through June 30, 2005. The daily weights of each patient totaled over 48,000 individual data points. The new grid differed from previously published grids, in that the new grid showed; (1) no predicted postnatal weight loss among neonates in categories<900 g birth weight, (2) less initial weight loss among neonates 900-2500 g, (3) fewer days to regain birth weight among neonates