1.
Chem Commun (Camb)
; 54(6): 654-657, 2018 Jan 16.
Artigo
em Inglês
| MEDLINE
| ID: mdl-29300400
RESUMO
A mild calcium catalysed Beckmann rearrangement has been realised, which forgoes the more traditional harsh reactions conditions associated with the transformation. The catalyst system is shown to be tolerant towards a wide variety of functional groups relevant to natural product synthesis and medicinal chemistry and the synthetic utility of the reaction has also been investigated. A preliminary mechanistic investigation was performed to understand the nature of the incoming nucleophile and a possible reaction pathway is described.