RESUMO
In coronary patients with relatively intact myocardial function, tobanum increases physical stress tolerance and produces positive central hemodynamic shifts, while myocardial contractility is depressed insignificantly. In patients with low myocardial functional reserve, these parameters, on the contrary, deteriorate, particularly during exercise. Combined use of tobanum and corinfar in patients with impaired myocardial contractility controls cardio- and hemodynamic shifts and increases physical stress tolerance.
Assuntos
Antagonistas Adrenérgicos beta/uso terapêutico , Doença das Coronárias/tratamento farmacológico , Coração/fisiopatologia , Propanolaminas/uso terapêutico , Adulto , Doença das Coronárias/fisiopatologia , Quimioterapia Combinada , Hemodinâmica , Humanos , Pessoa de Meia-Idade , Contração Miocárdica , Nifedipino/administração & dosagem , Esforço Físico , Propanolaminas/administração & dosagemRESUMO
Hypertensive crises were studied in 80 patients. In severe cases the ECG provided evidence of systolic overloading of the left ventricle with intensification of coronary circulation and development of acute myocardial ischemia. Phase analysis showed prolongation of the mechanical systole with increase of the myocardial index. In more complicated cases there was a more evident hypodynamic syndrome with marked myocardial insufficiency. Hemodynamic disturbance were marked by a sharply increased peripheral resistance with a heterogenous reaction of the cardiac output. Blood supply to the cerebral tissue reduced sharply with an increase in the resistance of cerebral vessels. Renin activity was directly related to the severity of the crisis. A sharp onset of cerebral and cardiac ischemia was marked by changes in the antigen albumin. Timely diagnosis and differentiated treatment made it possible to avoid vascular complications in hypertensive crisis.