A relação entre os mecanismos que influenciam o propósito de vida e seus impactos na longevidade em idosos com mais de 80 anos / The relationship between the mechanisms that influence purpose in life and its impacts on longevity in the oldest-old / La relación entre los mecanismos que influyen en el propósito de la vida y sus impactos sobre la longevidad en las personas mayores de 80 años

Revisão integrativa da literatura que investigou a relação entre mecanismos que influenciam o propósito de vida (PDV) e seus impactos na longevidade,em idosos com mais de 80 anos. Encontraram-se oito trabalhos (bases de dados: LILACS, Medline, CINAHL, Web of Science, Scopus e SciELO).O PDV elevado aumenta as chances de um envelhecimento bem-sucedido e melhores desfechos em saúde; porém, não protege de depressão no futuro.O PDV deve ser fortalecido por intervenções que considerem questões existenciais e subjetivas de longevos.

Integrative literature review investigated the relationship between the mechanisms that influence purpose in life (PIL) and its impacts on longevity in the oldest-old. Eight papers were selected (databases: LILACS, Medline, CINAHL, Web of Science, Scopus and SciELO). High levels of PIL increases chances of successful aging and better outcomes in health. However, it does not protect against depression in the future.PIL must be strengthened through interventions considering existential and subjective issues of the oldest-old.

Revisión de literatura integradora que investigó la relación entre los mecanismos que influyen en el propósito de la vida (POS) y sus impactos en la longevidad, en personas mayores de 80 años. Se encontraron ocho estudios (bases de datos: LILACS, Medline, CINAHL, Web of Science, Scopus y SciELO). POS elevado aumenta las posibilidades de envejecimiento exitoso y mejores resultados de salud; sin embargo, no lo protege de la depresión en el futuro. El POS debe fortalecerse mediante intervenciones que tengan en cuenta los problemas existenciales y subjetivos de las personas de larga vida.

Dorsomedial hypothalamus serotonin 1A receptors mediate a panic-related response in the elevated T-maze.

The dorsomedial hypothalamus (DMH) has long been associated with the regulation of escape, a panic-related defensive response. Previous evidence has shown that the activation of serotonin (5-HT) 1A and 2A receptors impairs escape behavior induced by the electrical stimulation of the same region. In this study we further explore the relationship of the DMH with defense by investigating the effects of 5-HT1A activation on escape behavior generated in male Wistar rats by an ethologically based aversive stimuli, exposure to one of the open arms of the elevated T-maze (ETM). Aside from escape, the ETM also allows the measurement of inhibitory avoidance, a defensive response associated with generalized anxiety disorder. To evaluate locomotor activity, after ETM measurements animals were submitted to an open field. Results showed that intra-DMH administration of the 5-HT1A receptor agonist 8-OH-DPAT inhibited escape expression. Local administration of the 5-HT1A antagonist WAY-100635 by its own was ineffective, but blocked the panicolytic-like effect of 8-OH-DPAT. Chronic (21 days) systemic treatment with imipramine potentiated the anti-escape effect of 8-OH-DPAT. No significant effects of treatment with 8-OH-DPAT or imipramine on avoidance latencies or the number of lines crossed in the open field were found. These results indicate that 5-HT1A receptors within the DMH may play a phasic inhibitory role on ETM escape expression. As previously proposed, facilitation of 5-HT1A-mediated neurotransmission in the DMH may be involved in the mechanism of action of anti-panic compounds.