[Comparative evaluation of clinical symptoms and status of bone metabolism in patients with heroin and buprenorphine addiction in the period of withdrawal].

The purpose of this study was the evaluation of clinical heroin symptoms and buprenorphine drug addiction in the withdrawal period with the purpose of their comparison, study of parameters of bone metabolism in the both groups. In the study group were included 40 patients with heroin and 27 with buprenorphine addiction in the period of abstinence. Our investigations have shown, that in the both groups, among clinical symptoms ossalgias, arthralgias and mialgias attributes to the expressed dysfunction of vegetative system, were most prominent. Decrease of sexual functions was found in half of inspected patients. Biochemical investigations have shown intensive clearance of calcium with the urine that indicates intensifying resorbtion processes in the bone tissue. Symptoms of hypogonadism were accompanied by the decrease of the level of testosterone in the blood. Parameters of mineral consistency of the bone tissue was decreased both in patients with heroin and buprenorphine addiction.

[The HLA system antigens in rheumatism]. / Antigeny sistemy HLA pri revmatizme.

The authors studied the distribution of class I and II HLA antigens in 51 Georgian patients with rheumatic heart disease. Statistically significant differences were found between the study group and controls, regarding HLA-AI, Aw19 and Bw22 distribution. The relative risk ratio was, respectively, 2.94, 3.82 and 4.40.

[A new immunogenetic marker of rheumatism]. / Novyi immunogeneticheskii marker revmatizma.

Use of monoclonal D8/17 antiserum was studied for identification of B-cell antigen in 44 rheumatic fever patients. The control group comprised healthy subjects (30) and patients suffering from rheumatoid arthritis (30), ischemic heart disease (IO); chronic tonsillitis (12) and different neoplasma of the brain (10). The preliminary genetic analysis of these patients has shown that monoclonal antiserum D8/17 can identify B-cell marker in 88-100 per cent of rheumatic fever cases.

[Prostaglandins and the immunological indices of patients with chronic heart failure]. / Prostaglandiny i nekotorye immunologicheskie pokazateli u bol'nykh s khronicheskoi serdechnoi nedostatochnost'iu.

Some indices of T and B cellular immunity and content of PgE2 and PgF2 alpha in the peripheral blood plasma were studied in 70 patients with coronary heart disease and in 22 patients with rheumatic disease complicated by chronic cardiac failure. It was revealed that increase in PgE2 and PgF2 alpha levels was accompanied by changes in T cells subpopulations. It is suggested that Pg-s can mediate changes of immunoregulatory lymphocyte functions in chronic cardiac insufficiency.