[The characteristics of the correlation of the functional activity, blood supply and structural organization in the sensory-deprived cerebral cortex in rats]. / Osobennosti korreliatsii funktsional'noi aktivnosti, krovosnabzheniia i strukturnoi organizatsii v sensorno-deprivirannoi kore mozga krys.

The feature of correlation between functional activity of the brain tissue and structural-functional characteristics of the vascular system after sensory deprivation by the removal of whiskers in newborn animals were studied in nembutal-anaesthetized rats in comparison to the animals under d-tubocurarine with local anesthesia. It has been shown that there are major changes of EP parameters and ECoG in the sensory-deprived brain area and diminution of brain cortex thickness. Changes in the vascular system are mainly structural, what are revealed as disorganization in angioarchitecture of radial arteries. At the same time, differences in the blood circulation intensity are found in d-tubocurarine animals only. The largest volume of the local blood circulation is observed in intact hemisphere of sensory-deprived animal. Thus, it can be concluded that sensory-deprived model is the alternative to the ischemia model. This model can be used in studies of physiology of brain blood circulation, and the "structure-function" correlation, in particular.

[The structuro-functional modulus of the microcirculatory network of the cerebral cortex in rats]. / Strukturno-funktsional'nyi modul' mikrotsirkuliatornoi seti kory golovnogo mozga krys.

Complex investigation carried out in rats with the aid of polarographic microelectrodes revealed a mosaic distribution of blood supply within a small volume of nerve tissue in resting. The activation of cortical neurons was accompanied by local functional hyperemia and increased level of oxygen available. The hyperemia spread over a 200-300 mu area corresponding to the sides of neuronal columns. The data obtained have shown that the system of the cortex blood circulation and oxygen transport to neural tissues is based on a special microcirculatory module responsible for circulatory-metabolic supply of separate groups of neurons and composed as vertically oriented columns.

[Distribution of oxygen tension in the brain of spontaneously hypertensive rats]. / Raspredelenie napriazheniia kisloroda v mozge spontanno gipertenzivnykh krys.

The distribution of cerebral tissue pO2 in spontaneously hypertensive Okamoto-Aoki rats (SHR) and normotensive Wistar-Kyoto rats (WK) was studied by means of polarographic microelectrodes 1-3 microns in diameter. SHR exhibited pO2 shifts towards low values and an increased heterogeneity of pO2 distribution in the cerebral tissue. Morphological studies of the brain have revealed diffuse and focal ischemia in the grey and white matter of the brain in SHR.