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1.
Addiction ; 112(8): 1451-1459, 2017 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-28239942

RESUMO

AIM: To test the potential benefit of extending cognitive-behavioral therapy (CBT) relative to not extending CBT on long-term abstinence from smoking. DESIGN: Two-group parallel randomized controlled trial. Patients were randomized to receive non-extended CBT (n = 111) or extended CBT (n = 112) following a 26-week open-label treatment. SETTING: Community clinic in the United States. PARTICIPANTS: A total of 219 smokers (mean age: 43 years; mean cigarettes/day: 18). INTERVENTION: All participants received 10 weeks of combined CBT + bupropion sustained release (bupropion SR) + nicotine patch and were continued on CBT and either no medications if abstinent, continued bupropion + nicotine replacement therapy (NRT) if increased craving or depression scores, or varenicline if still smoking at 10 weeks. Half the participants were randomized at 26 weeks to extended CBT (E-CBT) to week 48 and half to non-extended CBT (no additional CBT sessions). MEASUREMENTS: The primary outcome was expired CO-confirmed, 7-day point-prevalence (PP) at 52- and 104-week follow-up. Analyses were based on intention-to-treat. FINDINGS: PP abstinence rates at the 52-week follow-up were comparable across non-extended CBT (40%) and E-CBT (39%) groups [odds ratio (OR) = 0.99; 95% confidence interval (CI) = 0.55, 1.78]. A similar pattern was observed across non-extended CBT (39%) and E-CBT (33%) groups at the 104-week follow-up (OR = 0.79; 95% CI= 0.44, 1.40). CONCLUSION: Prolonging cognitive-behavioral therapy from 26 to 48 weeks does not appear to improve long-term abstinence from smoking.


Assuntos
Bupropiona/uso terapêutico , Fumar Cigarros/terapia , Terapia Cognitivo-Comportamental/métodos , Agonistas Nicotínicos/uso terapêutico , Abandono do Hábito de Fumar/métodos , Dispositivos para o Abandono do Uso de Tabaco , Adolescente , Adulto , Idoso , Feminino , Seguimentos , Humanos , Masculino , Pessoa de Meia-Idade , Tempo , Resultado do Tratamento , Estados Unidos , Adulto Jovem
2.
BMJ Open ; 6(6): e010960, 2016 06 29.
Artigo em Inglês | MEDLINE | ID: mdl-27357195

RESUMO

OBJECTIVE: The goal of the current study was to empirically compare successive cohorts of treatment-seeking smokers who enrolled in randomised clinical trials in a region of the USA characterised by strong tobacco control policies and low smoking prevalence, over the past three decades. DESIGN: Retrospective treatment cohort comparison. SETTING: Data were collected from 9 randomised clinical trials conducted at Stanford University and the University of California, San Francisco, between 1990 and 2013. PARTICIPANTS: Data from a total of 2083 participants were included (Stanford, n=1356; University of California San Francisco, n=727). PRIMARY AND SECONDARY OUTCOMES: One-way analysis of variance and covariance, χ(2) and logistic regression analyses were used to examine relations between nicotine dependence, cigarettes per day, depressive symptoms and demographic characteristics among study cohorts. RESULTS: Similar trends were observed at both settings. When compared to earlier trials, participants in more recent trials smoked fewer cigarettes, were less nicotine-dependent, reported more depressive symptoms, were more likely to be male and more likely to be from a minority ethnic/racial group, than those enrolled in initial trials (all p's<0.05). Analysis of covariances revealed that cigarettes per day, nicotine dependence and current depressive symptom scores were each significantly related to trial (all p's<0.001). CONCLUSIONS: Our findings suggest that more recent smoking cessation treatment-seeking cohorts in a low prevalence region were characterised by less smoking severity, more severe symptoms of depression and were more likely to be male and from a minority racial/ethnic group.


Assuntos
Saúde Pública , Fumantes/psicologia , Abandono do Hábito de Fumar/estatística & dados numéricos , Fumar/efeitos adversos , Adolescente , Adulto , Etnicidade , Feminino , Conhecimentos, Atitudes e Prática em Saúde , Humanos , Masculino , Pessoa de Meia-Idade , Aceitação pelo Paciente de Cuidados de Saúde/psicologia , Prevalência , Ensaios Clínicos Controlados Aleatórios como Assunto , Estudos Retrospectivos , São Francisco/epidemiologia , Fumantes/educação , Abandono do Hábito de Fumar/psicologia
3.
Nicotine Tob Res ; 17(9): 1126-33, 2015 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-25572450

RESUMO

INTRODUCTION: Current treatments for smoking cessation have limited efficacy. A potential pharmaceutical treatment for smoking cessation is selegiline, a selective and irreversible monoamine oxidase B inhibitor. A few clinical trials have been carried out using selegiline but the results have been mixed. We sought to determine if genetic markers in cholinergic loci in the 15q24 chromosomal region predict response to smoking cessation therapy with selegiline. METHODS: We performed an 8-week double-blind, placebo-controlled clinical trial of the selegiline transdermal system in heavy smokers, with follow-up at weeks 25 and 52. Eight single nucleotide polymorphisms (SNPs) in the 15q24 region, which contains the genes for the nicotinic acetylcholine receptor subunits CHRNA5, CHRNA3, and CHRNB4, were investigated for association with treatment response. RESULTS: The CHRNB4 promoter SNP rs3813567 was associated with both point prevalence abstinence and post-quit craving. Carriers of the minor C allele treated with selegiline showed lower rates of abstinence and higher levels of craving than selegiline-treated non-carriers, indicating that the rs3813567 C allele adversely affects abstinence in selegiline-treated smokers. This effect was not present among placebo-treated smokers. Selegiline-treated smokers with the CHRNA5 rs680244 GG genotype had lower post-quit craving, and unlike placebo-treated GG-carrying smokers, did not experience a post-quit increase in depressive symptoms. CONCLUSIONS: Variants in genes encoding cholinergic receptors affect abstinence, craving and mood in selegiline-treated smokers. Selegiline primarily affects dopamine levels in the brain, but cholinergic input affects nicotine-induced dopaminergic activity. These markers may have value in identifying those likely to respond to selegiline for smoking cessation.


Assuntos
Cromossomos Humanos Par 15/genética , Inibidores da Monoaminoxidase/uso terapêutico , Selegilina/uso terapêutico , Abandono do Hábito de Fumar/métodos , Tabagismo/genética , Tabagismo/prevenção & controle , Administração Cutânea , Adolescente , Adulto , Idoso , Alelos , Fissura/efeitos dos fármacos , Método Duplo-Cego , Feminino , Marcadores Genéticos , Humanos , Masculino , Pessoa de Meia-Idade , Polimorfismo de Nucleotídeo Único , Receptores Nicotínicos/genética , Adulto Jovem
4.
Contemp Clin Trials ; 36(2): 421-35, 2013 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-24028942

RESUMO

OBJECTIVE: To test the effects of a three-year, community-based, multi-component, multi-level, multi-setting (MMM) approach for treating overweight and obese children. DESIGN: Two-arm, parallel group, randomized controlled trial with measures at baseline, 12, 24, and 36 months after randomization. PARTICIPANTS: Seven through eleven year old, overweight and obese children (BMI ≥ 85th percentile) and their parents/caregivers recruited from community locations in low-income, primarily Latino neighborhoods in Northern California. INTERVENTIONS: Families are randomized to the MMM intervention versus a community health education active-placebo comparison intervention. Interventions last for three years for each participant. The MMM intervention includes a community-based after school team sports program designed specifically for overweight and obese children, a home-based family intervention to reduce screen time, alter the home food/eating environment, and promote self-regulatory skills for eating and activity behavior change, and a primary care behavioral counseling intervention linked to the community and home interventions. The active-placebo comparison intervention includes semi-annual health education home visits, monthly health education newsletters for children and for parents/guardians, and a series of community-based health education events for families. MAIN OUTCOME MEASURE: Body mass index trajectory over the three-year study. Secondary outcome measures include waist circumference, triceps skinfold thickness, accelerometer-measured physical activity, 24-hour dietary recalls, screen time and other sedentary behaviors, blood pressure, fasting lipids, glucose, insulin, hemoglobin A1c, C-reactive protein, alanine aminotransferase, and psychosocial measures. CONCLUSIONS: The Stanford GOALS trial is testing the efficacy of a novel community-based multi-component, multi-level, multi-setting treatment for childhood overweight and obesity in low-income, Latino families.


Assuntos
Obesidade Infantil/terapia , Programas de Redução de Peso/métodos , Criança , Aconselhamento , Dieta/métodos , Terapia Familiar/métodos , Comportamento Alimentar/psicologia , Feminino , Humanos , Masculino , Atividade Motora , Sobrepeso/terapia , Comportamento de Redução do Risco , Serviços de Saúde Escolar , Método Simples-Cego , Esportes
5.
Nicotine Tob Res ; 15(10): 1655-62, 2013 Oct.
Artigo em Inglês | MEDLINE | ID: mdl-23460656

RESUMO

INTRODUCTION: Relatively few well-designed smoking cessation studies have been conducted with teen smokers. This study examined the efficacy of extended cognitive-behavioral treatment in promoting longer term smoking cessation among adolescents. METHODS: Open-label smoking cessation treatment consisted of 10 weeks of school-based, cognitive-behavioral group counseling along with 9 weeks of nicotine replacement (nicotine patch). A total of 141 adolescent smokers in continuation high schools in the San Francisco Bay Area were randomized to either 9 additional group sessions over a 14-week period (extended group) or 4 monthly smoking status calls (nonextended group). Intention-to-treat logistic regression analysis was used to assess the primary outcome of biologically confirmed (carbon monoxide < 9 ppm) point prevalence abstinence at Week 26 (6-month follow-up from baseline). RESULTS: At Week 26 follow-up, the extended treatment group had a significantly higher abstinence rate (21%) than the nonextended treatment (7%; OR = 4.24, 95% CI: 1.20-15.02). Females also were more likely to be abstinent at the follow-up than males (OR = 4.15, 95% CI: 1.17-14.71). CONCLUSIONS: The significantly higher abstinence rate at follow-up for the extended treatment group provides strong support for continued development of longer term interventions for adolescent smoking cessation.


Assuntos
Nicotina/uso terapêutico , Abandono do Hábito de Fumar/métodos , Prevenção do Hábito de Fumar , Fumar/tratamento farmacológico , Adolescente , Feminino , Humanos , Masculino , Resultado do Tratamento
6.
Paediatr Drugs ; 14(2): 91-108, 2012 Apr 01.
Artigo em Inglês | MEDLINE | ID: mdl-22248234

RESUMO

Adolescent smoking remains a public health problem. Despite concerns regarding adolescent nicotine dependence, few well-designed smoking cessation studies have been conducted with teen smokers. This is particularly true regarding pharmacologic treatments for nicotine dependence. Currently, pharmacologic aids are not recommended for treating adolescent nicotine dependence, as efficacy has not been shown in this population. This review includes studies that have examined the efficacy of pharmacotherapy for smoking abstinence and/or reduction in cigarette consumption among adolescent smokers who want to quit smoking, laboratory-based adolescent studies that have examined the efficacy of these medications in reducing cravings and/or withdrawal symptoms, and/or studies that have assessed the tolerability of medications for smoking cessation in adolescent smokers. It provides information on the pharmacologic action of each medication, the efficacy of each medication for adolescent smoking cessation, the tolerability of each medication based on reported adverse events, and compliance with the medication protocols. Thirteen relevant articles were identified and included in the review. Nicotine patch (NP), nicotine gum, nicotine nasal spray, bupropion, and varenicline have been studied in adolescent smokers. The adverse events reported in the studies on pharmacology for adolescent smoking suggest that the side effect profiles for nicotine replacement therapy, bupropion, and varenicline are similar to those reported in adult studies. There is some evidence of efficacy of NP and bupropion at the end of treatment (efficacy of varenicline has not been assessed), but none of the medications included in this review were efficacious in promoting long-term smoking cessation among adolescent smokers. It is noted that many of the study protocols did not follow the recommended dose or length of pharmacotherapy for adults, rendering it difficult to determine the true efficacy of medication for adolescent smoking cessation. Future efficacy studies are warranted before recommending pharmacotherapy for adolescent smoking cessation.


Assuntos
Benzazepinas/uso terapêutico , Bupropiona/uso terapêutico , Nicotina/uso terapêutico , Agonistas Nicotínicos/uso terapêutico , Medicamentos sob Prescrição/uso terapêutico , Quinoxalinas/uso terapêutico , Abandono do Hábito de Fumar/métodos , Síndrome de Abstinência a Substâncias/prevenção & controle , Dispositivos para o Abandono do Uso de Tabaco/estatística & dados numéricos , Adolescente , Benzazepinas/administração & dosagem , Benzazepinas/efeitos adversos , Bupropiona/administração & dosagem , Bupropiona/efeitos adversos , Ensaios Clínicos como Assunto , Inibidores da Captação de Dopamina/uso terapêutico , Humanos , Nicotina/administração & dosagem , Nicotina/efeitos adversos , Agonistas Nicotínicos/administração & dosagem , Agonistas Nicotínicos/efeitos adversos , Cooperação do Paciente/estatística & dados numéricos , Quinoxalinas/administração & dosagem , Quinoxalinas/efeitos adversos , Ensaios Clínicos Controlados Aleatórios como Assunto , Segurança , Síndrome de Abstinência a Substâncias/tratamento farmacológico , Resultado do Tratamento , Vareniclina
7.
Drug Alcohol Depend ; 120(1-3): 242-5, 2012 Jan 01.
Artigo em Inglês | MEDLINE | ID: mdl-21885211

RESUMO

BACKGROUND: Adolescent cigarette smokers may have more daily variability in their smoking patterns than adults. A better understanding of teen smoking patterns can inform the development of more effective adolescent smoking cessation interventions. METHODS: Teen smokers seeking cessation treatment (N=366) reported the number of cigarettes smoked on each day of a typical week. A paired t-test was used to examine differences between weekday (Sunday-Thursday) and weekend (Friday-Saturday) smoking. Main effects and interactions for race/ethnicity and gender were assessed using a 2-way ANOVA for the following variables: typical weekly smoking, average weekday smoking, average weekend smoking, and difference between weekday and weekend smoking. Scheffé post hoc tests were used to analyze any statistically significant differences. RESULTS: There was significantly more weekend smoking compared to weekday smoking, p<0.001. The difference in weekday versus weekend smoking levels was larger for females than for males, p<0.05. Hispanics reported less typical weekly smoking, p<0.001, less weekday smoking, p<0.001, and less weekend day smoking, p<0.01, compared to Caucasians and multi-racial teens. There was no difference in weekend day versus weekday smoking by race/ethnic background. CONCLUSIONS: Using a more detailed assessment of smoking quantity captures patterns of adolescent smoking that may lead to more effective smoking cessation interventions.


Assuntos
Fumar/epidemiologia , Adolescente , California/epidemiologia , Feminino , Humanos , Masculino , Grupos Raciais/estatística & dados numéricos , Fatores Sexuais , Fatores de Tempo
8.
Nicotine Tob Res ; 13(11): 1092-7, 2011 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-21832272

RESUMO

INTRODUCTION: The factors that influence the initial phase of quitting smoking have been understudied. Although maintenance of change is the ultimate test of the efficacy of treatment, maintenance is a nonissue for those who fail to manage even brief periods of abstinence. We examined factors associated with smokers' ability to achieve a targeted 24-hr quit during a smoking cessation program. As a comparison, we also examine whether predictors of an initial quit are different from factors that predict smoking abstinence at 52-week follow-up. METHODS: Using baseline data from a randomized clinical trial to examine the efficacy of selegiline for cigarette smoking cessation (n = 280), we conducted univariate analyses (analysis of variance or chi-square) to determine statistically significant predictors of a successful quit attempt (SQA) versus unsuccessful quit attempt. Multiple logistic regression was performed with significant predictors from the univariate analyses to determine main effects and interactions in a multivariate model. The same factors and analyses were used to examine predictors of 52-week point prevalence abstinence. RESULTS: Lower nicotine dependence (modified Fagerström Tolerance Questionnaire [mFTQ]), higher Behavioral Inhibition System score, and lower baseline heart rate were predictive of SQA in both the univariate and the multivariate models. Gender was the only predictor of 52-week smoking abstinence. CONCLUSIONS: Predictors of initial induction of change were not predictors of abstinence at the 1-year follow-up, suggesting that different factors mediate the different subprocesses of behavior change. Knowledge of these pretreatment factors that moderate a SQA could help clinicians target smokers who need more intensive therapy during the initial induction of cessation.


Assuntos
Inibidores da Monoaminoxidase/uso terapêutico , Selegilina/uso terapêutico , Abandono do Hábito de Fumar/métodos , Prevenção do Hábito de Fumar , Tabagismo/terapia , Adulto , Terapia Comportamental , Método Duplo-Cego , Feminino , Seguimentos , Promoção da Saúde , Humanos , Modelos Logísticos , Masculino , Pessoa de Meia-Idade , Autorrelato , Fatores Sexuais , Abandono do Hábito de Fumar/estatística & dados numéricos , Fatores de Tempo , Adesivo Transdérmico , Resultado do Tratamento
9.
Am J Med Genet B Neuropsychiatr Genet ; 156B(3): 275-84, 2011 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-21268243

RESUMO

Stopping smoking is difficult even with treatment. Many patients prescribed pharmacologic treatments for smoking cessation experience side effects or lack of efficacy. We performed a pharmacogenetic study of the efficacy and tolerability of bupropion and transdermal nicotine (TN), two treatments for smoking cessation. Samples were drawn from two studies. In the first study (Maintenance 1, MT1), 301 smokers received bupropion plus TN for 11 weeks, followed by 14 weeks of placebo or bupropion. In the second study (MT2), 276 smokers received bupropion and TN for 8 weeks. We focused on eight SNPs in the 15q24 region, which contains the genes for the nicotinic cholinergic receptor subunits CHRNA5, CHRNA3, and CHRNB4, and has previously been implicated in nicotine addiction and smoking cessation. Analyses of baseline smoking quantity (SQ) identified an association between SQ and both the functional CHRNA5 SNP rs16969968 (D398N) and the CHRNA3 SNP rs1051730 (Y215Y) in a combined cohort containing MT1 and MT2. An association between SQ and ethnicity was also identified in the combined cohort. Pharmacogenetic analysis showed a significant association between rs8192475 (R37H) in CHRNA3 and both higher craving after quitting and increased withdrawal symptoms over time in MT2. Two markers for point prevalence abstinence, CHRNA5 SNP rs680244 and CHRNB4 SNP rs12914008, were also identified in MT2, with the strongest findings at week 52. These results provide further support for the role of the CHRNA5/A3/B4 subunits in determining number of cigarettes smoked and response to smoking cessation therapy.


Assuntos
Cromossomos Humanos Par 15/genética , Família Multigênica/genética , Subunidades Proteicas/genética , Receptores Nicotínicos/genética , Abandono do Hábito de Fumar , Tabagismo/genética , Tabagismo/terapia , Alelos , Estudos de Coortes , Demografia , Frequência do Gene/genética , Marcadores Genéticos , Humanos , Desequilíbrio de Ligação/genética , Polimorfismo de Nucleotídeo Único/genética , Análise de Regressão , Tabagismo/etnologia , Resultado do Tratamento , População Branca/genética
10.
Arch Pediatr Adolesc Med ; 164(11): 995-1004, 2010 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-21041592

RESUMO

OBJECTIVE: To test a 2-year community- and family-based obesity prevention program for low-income African American girls: Stanford GEMS (Girls' health Enrichment Multi-site Studies). DESIGN: Randomized controlled trial with follow-up measures scheduled at 6, 12, 18, and 24 months. SETTING: Low-income areas of Oakland, California. PARTICIPANTS: African American girls aged 8 to 10 years (N=261) and their parents or guardians. INTERVENTIONS: Families were randomized to one of two 2-year, culturally tailored interventions: (1) after-school hip-hop, African, and step dance classes and a home/family-based intervention to reduce screen media use or (2) information-based health education. MAIN OUTCOME MEASURE: Changes in body mass index (BMI). RESULTS: Changes in BMI did not differ between groups (adjusted mean difference [95% confidence interval] = 0.04 [-0.18 to 0.27] per year). Among secondary outcomes, fasting total cholesterol level (adjusted mean difference, -3.49 [95% confidence interval, -5.28 to -1.70] mg/dL per year), low-density lipoprotein cholesterol level (-3.02 [-4.74 to -1.31] mg/dL per year), incidence of hyperinsulinemia (relative risk, 0.35 [0.13 to 0.93]), and depressive symptoms (-0.21 [-0.42 to -0.001] per year) decreased more among girls in the dance and screen time reduction intervention. In exploratory moderator analysis, the dance and screen time reduction intervention slowed BMI gain more than health education among girls who watched more television at baseline (P = .02) and/or those whose parents or guardians were unmarried (P = .01). CONCLUSIONS: A culturally tailored after-school dance and screen time reduction intervention for low-income, preadolescent African American girls did not significantly reduce BMI gain compared with health education but did produce potentially clinically important reductions in lipid levels, hyperinsulinemia, and depressive symptoms. There was also evidence for greater effectiveness in high-risk subgroups of girls.


Assuntos
Negro ou Afro-Americano/educação , Dança , Educação em Saúde/métodos , Obesidade/prevenção & controle , Negro ou Afro-Americano/psicologia , Índice de Massa Corporal , California , Distribuição de Qui-Quadrado , Criança , Características Culturais , Feminino , Seguimentos , Humanos , Lipídeos/sangue , Pobreza , Análise de Regressão , Comportamento Sedentário , Televisão , Resultado do Tratamento
11.
Addiction ; 105(9): 1660-8, 2010 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-20707784

RESUMO

AIMS: To examine the effectiveness of transdermal selegiline for producing cigarette smoking abstinence. DESIGN: Adult smokers were randomly assigned to receive selegiline transdermal system (STS) or placebo given for 8 weeks. All participants received cognitive behavior therapy (CBT). Follow-ups were conducted at 25 and 52 weeks. SETTING: Community smoking cessation clinic. PARTICIPANTS: 243 adult smokers (> or =18 years of age; > or =10 cigarettes/day). MEASURES: Expired-air carbon monoxide confirmed 7-day point prevalence abstinence. FINDINGS: STS was not superior to placebo. More women than men were abstinent at 52 week follow-up (28% vs 16%, P < 0.05). Behavioral activation (BAS) moderated treatment response (P = 0.01). The survival rate through week 52 for those with high 'drive' scores on the BAS was 47% if assigned to selegiline and 34% if assigned to placebo. The survival rate for those with low 'drive scores' on the BAS was 35% if assigned to selegiline compared to 53% if assigned to placebo. CONCLUSION: Transdermal selegiline does not appear generally effective in aiding smoking cessation though there may be a selective effect in those smokers with low 'behavioral activation'.


Assuntos
Inibidores da Monoaminoxidase/uso terapêutico , Selegilina/uso terapêutico , Abandono do Hábito de Fumar/métodos , Fumar/tratamento farmacológico , Tabagismo/tratamento farmacológico , Administração Cutânea , Adolescente , Adulto , Idoso , Terapia Comportamental , Testes Respiratórios , Monóxido de Carbono/análise , Feminino , Humanos , Estimativa de Kaplan-Meier , Masculino , Adesão à Medicação , Pessoa de Meia-Idade , Inibidores da Monoaminoxidase/administração & dosagem , Motivação , Recidiva , Análise de Regressão , Selegilina/administração & dosagem , Distribuição por Sexo , Fumar/psicologia , Síndrome de Abstinência a Substâncias/tratamento farmacológico , Resultado do Tratamento , Adulto Jovem
12.
Am J Health Behav ; 34(6): 801-10, 2010.
Artigo em Inglês | MEDLINE | ID: mdl-20604703

RESUMO

OBJECTIVES: To identify distinct subgroups of treatment responders and nonresponders to aid in the development of tailored smoking-cessation interventions for long-term maintenance using signal detection analysis (SDA). METHODS: The secondary analyses (n = 301) are based on data obtained in our randomized clinical trial designed to assess the efficacy of extended cognitive behavior therapy for cigarette smoking cessation. Model 1 included only pretreatment factors, demographic characteristics, and treatment assignment. Model 2 included all Model 1 variables, as well as clinical data measured during treatment. RESULTS: SDA was successfully able to identify smokers with varying probabilities of maintaining abstinence from end-of-treatment to 52-week follow-up; however, the inclusion of clinical data obtained over the course of treatment in Model 2 yielded very different partitioning parameters. CONCLUSIONS: The findings from this study may enable researchers to target underlying factors that may interact to promote maintenance of long-term smoking behavior change.


Assuntos
Avaliação de Processos e Resultados em Cuidados de Saúde/métodos , Abandono do Hábito de Fumar/métodos , Tabagismo/prevenção & controle , Tabagismo/terapia , Adolescente , Adulto , Idoso , Terapia Cognitivo-Comportamental/métodos , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Modelos Psicológicos , Ensaios Clínicos Controlados Aleatórios como Assunto , Prevenção Secundária , Detecção de Sinal Psicológico , Tabagismo/classificação
13.
J Subst Abuse Treat ; 39(2): 150-6, 2010 Sep.
Artigo em Inglês | MEDLINE | ID: mdl-20598833

RESUMO

This study assessed the relationship between treatment outcome and perceived drug assignment in smokers (nicotine patch [NP] or placebo) using abstinence and relapse status. Smokers (N = 424) were randomly assigned to receive either NP or placebo as part of a study that examined the effects of combining NP with self-help programs. Beliefs about drug assignment, assessed at the 12-month follow-up, were obtained from 384 participants. Beliefs were related to abstinence at the 2-month, p < .05, and 6-month follow-ups, p < .05, for the NP group, but not the placebo. Beliefs were not related to abstinence at 12 months for either group. Survival analysis assessing relapse revealed that beliefs were related to relapse status, regardless of actual group assignment. Our results suggest that there is a relationship between perceived drug assignment and treatment outcome. Future studies using multiple treatment outcome measures and assessments of beliefs over time are warranted.


Assuntos
Nicotina/administração & dosagem , Abandono do Hábito de Fumar/métodos , Administração Cutânea , Adulto , Método Duplo-Cego , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Resultado do Tratamento
14.
Addict Behav ; 34(12): 1017-22, 2009 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-19647373

RESUMO

Nicotine dependence may be expressed differently in teens than in adults. Thus, it may not be sufficient to build diagnostic and cessation treatment strategies for teens based on adult-derived clinical and research data. This is the first study to prospectively examine the development of withdrawal symptoms by level of nicotine dependence among adolescent smokers. Forty-seven adolescent smokers completed nicotine withdrawal symptoms measures during 10 weeks of cessation treatment. Nicotine dependence was assessed at baseline using the mFTQ. Change in withdrawal symptoms over time by level of nicotine dependence was examined via mixed model ANOVA. Nicotine withdrawal in daily adolescent smokers was strongly and prospectively associated with the level of nicotine dependence. Craving was rated as the most problematic symptom at the baseline assessment. The results of this study may help guide the development of future research on diagnostic and cessation treatment strategies for teens.


Assuntos
Abandono do Hábito de Fumar , Fumar/efeitos adversos , Síndrome de Abstinência a Substâncias/epidemiologia , Tabagismo/epidemiologia , Adolescente , Análise de Variância , Feminino , Humanos , Masculino , Estudos Prospectivos , São Francisco/epidemiologia , Fumar/terapia , Inquéritos e Questionários
15.
Addiction ; 103(8): 1381-90, 2008 Aug.
Artigo em Inglês | MEDLINE | ID: mdl-18855829

RESUMO

UNLABELLED: PRIMARY AIM: Examine the effectiveness of extended cognitive behavior therapy (CBT) in promoting longer-term smoking abstinence. DESIGN: Open-label treatment phase followed by extended treatment phase. Randomization conducted prior to entry into open-label treatment phase; analysis based on intention-to-treat to avoid threat of selection bias. SETTING: Community smoking cessation clinic. PARTICIPANTS: A total of 304 adult smokers (> or = 18 years of age; > or = 10 cigarettes/day). INTERVENTION: Open-label (8 weeks): all participants received bupropion SR, nicotine patch, CBT. Extended treatment (12 weeks): participants received either CBT + voicemail monitoring and telephone counseling or telephone-based general support. MEASUREMENTS: Seven-day point prevalence abstinence, expired-air carbon monoxide. RESULTS: At week 20 follow-up, CBT produced a higher 7-day point prevalence abstinence rate: 45% versus 29%, P = 0.006; at 52 weeks the difference in abstinence rates (31% versus 27%) was not significant. History of depression was a moderator of treatment. Those with a positive history had a better treatment response at 20 weeks when assigned to the less intensive telephone support therapy (P < 0.05). CONCLUSION: The superiority of CBT to 20 weeks suggests that continued emphasis on the development of cognitive and behavioral strategies for maintaining non-smoking during an extended treatment phase may help smokers to maintain abstinence in the longer term. At present, the minimum duration of therapy is unknown.


Assuntos
Bupropiona/administração & dosagem , Terapia Cognitivo-Comportamental/métodos , Inibidores da Captação de Dopamina/administração & dosagem , Nicotina/administração & dosagem , Agonistas Nicotínicos/administração & dosagem , Abandono do Hábito de Fumar/métodos , Adulto , Monóxido de Carbono/análise , Aconselhamento , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Cooperação do Paciente , Síndrome de Abstinência a Substâncias/tratamento farmacológico
16.
Contemp Clin Trials ; 29(1): 56-69, 2008 Jan.
Artigo em Inglês | MEDLINE | ID: mdl-17600772

RESUMO

OBJECTIVE: African-American girls and women are at high risk of obesity and its associated morbidities. Few studies have tested obesity prevention strategies specifically designed for African-American girls. This report describes the design and baseline findings of the Stanford GEMS (Girls health Enrichment Multi-site Studies) trial to test the effect of a two-year community- and family-based intervention to reduce weight gain in low-income, pre-adolescent African-American girls. DESIGN: Randomized controlled trial with measurements scheduled in girls' homes at baseline, 6, 12, 18 and 24 month post-randomization. SETTING: Low-income areas of Oakland, CA. PARTICIPANTS: Eight, nine and ten year old African-American girls and their parents/caregivers. INTERVENTIONS: Girls are randomized to a culturally-tailored after-school dance program and a home/family-based intervention to reduce screen media use versus an information-based community health education Active-Placebo Comparison intervention. Interventions last for 2 years for each participant. MAIN OUTCOME MEASURE: Change in body mass index over the two-year study. RESULTS: Recruitment and enrollment successfully produced a predominately low-socioeconomic status sample. Two-hundred sixty one (261) families were randomized. One girl per family is randomly chosen for the analysis sample. Randomization produced comparable experimental groups with only a few statistically significant differences. The sample had a mean body mass index (BMI) at the 74 th percentile on the 2000 CDC BMI reference, and one-third of the analysis sample had a BMI at the 95th percentile or above. Average fasting total cholesterol and LDL cholesterol were above NCEP thresholds for borderline high classifications. Girls averaged low levels of moderate to vigorous physical activity, more than 3 h per day of screen media use, and diets high in energy from fat. CONCLUSIONS: The Stanford GEMS trial is testing the benefits of culturally-tailored after-school dance and screen-time reduction interventions for obesity prevention in low-income, pre-adolescent African-American girls.


Assuntos
Negro ou Afro-Americano , Educação em Saúde/organização & administração , Obesidade/prevenção & controle , Pobreza , Índice de Massa Corporal , Criança , Colesterol/sangue , Dieta , Feminino , Humanos , Autoimagem , Fatores Socioeconômicos
17.
Depress Anxiety ; 25(3): 200-6, 2008.
Artigo em Inglês | MEDLINE | ID: mdl-17348001

RESUMO

To evaluate a developmental psychopathology approach for understanding adolescent social anxiety, parent-reported predictors of social anxiety were examined in a nonclinical sample of adolescents. Structured diagnostic interviews were obtained from biological parents of 770 participants. Potential risk factors assessed included child characteristics: negative affect, shyness, separation anxiety disorder, and childhood chronic illness, as well as parent characteristics: major depression, panic disorder, and agoraphobia. Adolescent social anxiety was measured multiple times during high school. Findings indicate stability in social anxiety symptoms across time. Parent-reported, childhood negative affect, shyness, and chronic illness as well as parental panic disorder or agoraphobia were associated with adolescent social anxiety. Interactions were observed between parent-reported childhood shyness and gender and between parent-reported childhood shyness and parent-reported childhood chronic illness in the prediction of social anxiety. Parent-reported childhood shyness was a stronger predictor of adolescent social anxiety in females compared to males. The combined effect of subjects being positive for both parent-reported childhood shyness and parent-reported childhood chronic illness was greater than would be expected based on additive effects. This study provides support for a multifactorial and developmentally informed understanding of adolescent social anxiety.


Assuntos
Desenvolvimento do Adolescente , Transtornos Fóbicos/psicologia , Psicologia do Adolescente , Adolescente , Agorafobia/diagnóstico , Agorafobia/epidemiologia , Ansiedade de Separação/diagnóstico , Ansiedade de Separação/epidemiologia , Criança , Comportamento Infantil/psicologia , Filho de Pais com Deficiência/psicologia , Filho de Pais com Deficiência/estatística & dados numéricos , Doença Crônica/epidemiologia , Transtorno Depressivo Maior/diagnóstico , Transtorno Depressivo Maior/epidemiologia , Feminino , Humanos , Masculino , Modelos Psicológicos , Transtorno de Pânico/diagnóstico , Transtorno de Pânico/epidemiologia , Pais/psicologia , Transtornos Fóbicos/diagnóstico , Escalas de Graduação Psiquiátrica , Fatores de Risco , Fatores Sexuais , Timidez , Estudantes/psicologia
18.
J Am Diet Assoc ; 106(11): 1861-5, 2006 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-17081838

RESUMO

Food-related parenting attitudes are thought to influence children's dietary intake and weight. The objective of this study was to examine the associations between mothers' reports of food-related parenting and children's dietary intake and body mass index (BMI). A sample of 108 Mexican-American fifth-grade children and their mothers were surveyed. Children's height, weight, and three 24-hour dietary recalls were collected. Mothers reported household food insecurity status and food-related parenting attitudes. Correlational analyses were calculated among dietary intake variables, children's BMI percentiles, and food-parenting behaviors. Mothers' pressure on their children to eat was inversely correlated with children's BMI. In food-insecure families, attitudes toward making healthful foods available were inversely associated with children's daily energy intake and BMI. In contrast, in food-secure families, attitudes about making healthful foods available were positively associated with children's fruit intake and percentage energy from fat, and parental modeling of healthful food behaviors was inversely associated with the energy density. In our sample of Mexican-American families, mothers' food-related parenting was associated with their children's weight and dietary intake. These associations differed in food-secure and food-insecure households. Overall, pressure to eat was highly associated with children's weight, but the temporal nature of these relationships cannot be discerned.


Assuntos
Dieta , Comportamento Alimentar/etnologia , Americanos Mexicanos , Mães/psicologia , Obesidade/etiologia , Poder Familiar , Adulto , Atitude Frente a Saúde , Estatura/fisiologia , Índice de Massa Corporal , Peso Corporal/fisiologia , California , Criança , Dieta/etnologia , Dieta/psicologia , Dieta/normas , Ingestão de Alimentos/fisiologia , Ingestão de Energia , Comportamento Alimentar/psicologia , Feminino , Abastecimento de Alimentos , Humanos , Masculino , Rememoração Mental , Obesidade/epidemiologia , Obesidade/prevenção & controle , Poder Familiar/etnologia , Poder Familiar/psicologia , Pobreza
19.
J Consult Clin Psychol ; 74(2): 286-94, 2006 Apr.
Artigo em Inglês | MEDLINE | ID: mdl-16649873

RESUMO

The authors present results of a randomized clinical trial of the efficacy of extended treatment with bupropion SR in producing longer term cigarette smoking cessation. Adult smokers (N = 362) received open-label treatment (11 weeks) that combined relapse prevention training, bupropion SR, and nicotine patch followed by extended treatment (14 weeks) with bupropion SR or matching placebo. Abstinence percentages were relatively high (week 11: 52%; week 25: bupropion, 42%; placebo, 38%; week 52: bupropion, 33%; placebo, 34%), but bupropion SR did not surpass placebo. Gender and baseline craving level were identified as significant, independent moderators of treatment response. Men were more likely to abstain than women (week 11: 59% vs. 43%, p = .001; week 25: 48% vs. 31%, p = .001; week 52: 39% vs. 27%, p = .01). Because most smokers suffer relapse with any current cessation treatment, the comparatively high abstinence percentages achieved in this trial are of interest.


Assuntos
Bupropiona/uso terapêutico , Abandono do Hábito de Fumar/métodos , Fumar/tratamento farmacológico , Adolescente , Adulto , Idoso , Bupropiona/administração & dosagem , Preparações de Ação Retardada/uso terapêutico , Feminino , Humanos , Masculino , Pessoa de Meia-Idade
20.
Addict Behav ; 29(8): 1517-26, 2004 Nov.
Artigo em Inglês | MEDLINE | ID: mdl-15451121

RESUMO

This is the first study to examine the prevalence and effects of major depression (MDD) in a sample of adolescent smokers (N = 211) undergoing treatment for nicotine dependence. We assessed MDD at baseline and end of treatment with the mood disorders portion of the Structured Clinical Interview for the Diagnostic and Statistical Manual of Mental Disorders, fourth edition (DSM-IV). Eleven percent of participants reported a history of MDD (6% of males and 21% of females). Study variables did not distinguish those with and without a history of MDD. End of treatment abstinence rates and relapse rates were similar in both groups. Two participants (1%), both female, experienced onset of MDD during the treatment. The findings provide further evidence that MDD is a comparatively common disorder among children and adolescents and that clinicians should monitor and be prepared to respond to depression that may emerge during the treatment of nicotine-dependent adolescents.


Assuntos
Transtorno Depressivo/etiologia , Tabagismo/psicologia , Adolescente , Transtorno Depressivo/diagnóstico , Transtorno Depressivo/epidemiologia , Diagnóstico Duplo (Psiquiatria) , Manual Diagnóstico e Estatístico de Transtornos Mentais , Feminino , Humanos , Masculino , Abandono do Hábito de Fumar/psicologia , Tabagismo/terapia , Resultado do Tratamento
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