Post-traumatic stress disorder, depression, and health-related quality of life in OEF/OIF veterans.

PURPOSE: Comorbid post-traumatic stress disorder (PTSD) and depression are often associated with negative physical and mental health outcomes in Operation Enduring Freedom/Operation Iraqi Freedom (OEF/OIF) combat veterans. The current study examines the individual contributions of these two disorders on health-related quality of life (HRQoL) in an OEF/OIF cohort. The study hypothesizes that PTSD and depression will each significantly predict lower physical and mental HRQoL even when controlling for overlapping symptoms: anhedonia, concentration, and insomnia. METHOD: Participants were 220 OEF/OIF combat veterans who completed an interview and self-report questionnaires examining study variables. All study hypotheses were tested with multiple regression analyses. RESULTS: PTSD and depression significantly contributed to mental and physical HRQoL, even after controlling for overlapping symptoms. However, while independent main effects of PTSD and depression, with and without overlapping symptoms, emerged for predicting mental HRQoL, no significant independent main effects emerged for predicting physical HRQoL. CONCLUSION: Findings suggest PTSD and depression contribute uniquely to the negative relationship with HRQoL, adding to the growing literature on distinctive and common effects of these disorders in OEF/OIF veterans. Results highlight the need to better understand the implications for assessment and treatment.

Trauma exposure, branch of service, and physical injury in relation to mental health among U.S. veterans returning from Iraq and Afghanistan.

Significant mental health symptoms are reported in troops deployed to Iraq and Afghanistan (OEF/OIF). Symptomatic troops are more likely to be discharged and become eligible for Department of Veterans Affairs (DVA) care. Prevalence and predictors of mental health symptoms were assessed in 339 OEF/OIF veterans and reservists registering at the San Diego DVA. Participants completed self-report questionnaires assessing combat exposure, posttraumatic stress disorder (PTSD) symptom frequency and severity, depression, and substance and alcohol abuse. A minority of participants (36%) did not screen positive for mental health symptoms; the remainder met threshold for caseness of PTSD, depression, or substance and alcohol abuse. Using a hierarchical logistic regression model, gender, age, race, and rank were not significantly related to PTSD caseness, whereas most recent branch of service and report of injury during combat were. Follow-up analyses revealed that trauma history and combat exposure varied by branch of service. Knowledge of base rates and vulnerability factors can aid in rapid detection of "at risk" individuals.