RESUMO
Specimens of heart, kidney, liver, lung, pancreas and skeletal muscle were collected at autopsy from 86 traumatic accident victims. The concentration of cadmium in the samples was determined by atomic absorption spectrophotometry. Tissue burdens and the body burden of cadmium were calculated using individual weights of different organs as a function of age. Total body burden reached its maximum level of approximately 8 mg, in the 30-39 year age group. The highest value (8.3 mg) was measured in the 40-49 year age group. The highest average value of tissue burdens at 40-49 years of age was in kidney (4.9 mg), the amount of cadmium diminishing in different tissues in the following order: liver (1.8 mg), muscle (0.15 mg), lung (0.09 mg), pancreas (0.06 mg) and heart (less than 0.01 mg). At a low level of exposure, kidneys and liver alone contain on an average 85% of the total body burden of cadmium. This value differs greatly from earlier reported figures of 45-50%.
Assuntos
Cádmio/análise , Adolescente , Adulto , Idoso , Carga Corporal (Radioterapia) , Criança , Pré-Escolar , Exposição Ambiental , Humanos , Lactente , Recém-Nascido , Rim/análise , Fígado/análise , Pulmão/análise , Pessoa de Meia-Idade , Músculos/análise , Miocárdio/análise , Pâncreas/análiseAssuntos
Cádmio/metabolismo , Adolescente , Adulto , Fatores Etários , Idoso , Aorta/metabolismo , Criança , Exposição Ambiental , Feminino , Humanos , Rim/metabolismo , Fígado/metabolismo , Pulmão/metabolismo , Masculino , Pessoa de Meia-Idade , Músculos/metabolismo , Miocárdio/metabolismo , Tamanho do Órgão , Pâncreas/metabolismo , Espectrofotometria Atômica , Distribuição TecidualRESUMO
Autopsy specimens of aorta, heart, kidney, liver, lung, pancreas and skeletal muscle were collected from 86 accident victims. The copper concentration in each tissue was determined with atomic absorption spectrophotometry. The descending order of the tissues in respect to copper concentration was: liver, heart, kidney, pancreas, lung, muscle, and aorta. No significant difference was found in the copper levels of samples from male and female autopsies. When the effect of age on the average copper concentration was studied, liver and kidney showed a decreasing concentration up to maturity, the copper concentration in pancreas and skeletal muscle showed a continuous decline with increasing age, and there was no clear-cut effect of age on the copper concentration of heart, lung and aorta. According to the results the Finnish population does not differ, on the average, from other populations with respect to tissue copper concentrations.
