Microstructured Surfaces for Reducing Chances of Fomite Transmission via Virus-Containing Respiratory Droplets.

Evaporation-induced particle aggregation in drying droplets is of significant importance in the prevention of pathogen transfer due to the possibility of indirect fomite transmission of the infectious virus particles. In this study, particle aggregation was directionally controlled using contact line dynamics (pinned or slipping) and geometrical gradients on microstructured surfaces by the systematic investigation of the evaporation process on sessile droplets and sprayed microdroplets laden with virus-simulant nanoparticles. Using this mechanism, we designed robust particle capture surfaces by significantly inhibiting the contact transfer of particles from fomite surfaces. For the proof-of-concept, interconnected hexagonal and inverted pyramidal microwall were fabricated using ultraviolet-based nanoimprint lithography, which is considered to be a promising scalable manufacturing process. We demonstrated the potentials of an engineered microcavity surface to limit the contact transfer of particle aggregates deposited with the evaporation of microdroplets by 93% for hexagonal microwall and by 96% for inverted pyramidal microwall. The particle capture potential of the interconnected microstructures was also investigated using biological particles, including adenoviruses and lung-derived extracellular vesicles. The findings indicate that the proposed microstructured surfaces can reduce the indirect fomite transmission of highly infectious agents, including norovirus, rotavirus, or SARS-CoV-2, via respiratory droplets.

Shape-Deformed Mushroom-like Reentrant Structures for Robust Liquid-Repellent Surfaces.

Artificial liquid-repellent surfaces inspired by biomimetic structures provide a wide range of functional surfaces for various practical applications, such as self-cleaning, antisticking, oil/water separation, and droplet manipulation. However, functional biomimetic structures cannot be fabricated using conventional techniques. For example, mushroom-like topologies on the skin of springtails, which are referred to as "doubly reentrant structures," have attracted significant attention owing to their extraordinary liquid-repellent properties. Current methods of fabricating these reentrant structures have several limitations, such as complex material systems, processing steps, and additional chemical treatments. This study proposed a simple micro-shape-deformed approach to fabricate mushroom-like reentrant structures by digital light processing, a three-dimensional (3D) printing technique, with volumetric shrinkage. The nonuniform cross-linking process and light propagation during photopolymerization caused the deformation of the topological patterns atop the micropillar arrays, resulting in bent structures for mushroom-like shape-deformed microarchitectures. This 3D-printed shape-deformed microstructure exhibits a highly stable liquid repellency without perfluorinated coatings.