RESUMO
Severe fever with thrombocytopenia syndrome (SFTS) is an arthropod-borne viral disease with a high mortality rate with high fever and thrombocytopenia. We investigated the clinical and epidemiological characteristics and viral genotypes from 2019 to 2021 in Gangwon Province, Korea. Of the 776 suspected cases, 62 were SFTS. The fatality rate was 11.5-28.6% (average rate, 19.4%), and the frequent clinical symptoms were high fever (95.2%), thrombocytopenia (95.2%), and leukopenia (90.3%). Hwacheon had the highest incidence rate per 100,000 persons at 8.03, followed by Inje and Yanggu (7.37 and 5.85, respectively). Goseong, Yangyang, and Hoengseong had rates of 2 or higher; Samcheok, Hongcheon, Jeongsen, and Yeonwol were 1.70-1.98, and Wonju, Gangneung, and Donghae were slightly lower, ranging from 0.31 to 0.74. Of the 57 cases with identified genotypes, eight genotypes (A, B1, B2, B3, C, D, E, and F) were detected, and the B2 genotype accounted for 54.4% (31 cases), followed by the A genotype at 22.8% (13 cases). The B2 and A genotypes were detected throughout Gangwon Province, and other genotypes, B1, B3, C, D, and F, were discovered in a few regions. In particular, genotype A could be further classified into subtypes. In conclusion, SFTS occurred throughout Gangwon Province, and Hwacheon had the highest incidence density. Multiple genotypes of SFTS were identified, with B2 and A being the most common. These findings provide important insights for the understanding and management of SFTS in this region.
RESUMO
BACKGROUND: Little is known about the relative contribution of long-term glycemic variability to the risk of macrovascular complications in type 2 diabetes. This study was conducted to evaluate the effect of A1C variability on the progression of carotid artery intima-media thickness (IMT) in type 2 diabetic patients. METHODS: Among type 2 diabetic patients who visited Hallym University Sacred Heart Hospital from March 2007 to September 2009, 120 patients who had carotid artery IMT measured annually and A1C checked every three months for at least one year were analyzed. Individual A1C variability was defined as the standard deviation (SD) of five A1C levels taken every three months for approximately one year. Change in IMT was defined as an increase in IMT on follow-up measurement. The association between the SD of A1C and changes in IMT was evaluated. RESULTS: With greater A1C variability, there was a greater increase in the mean IMT (r = 0.350, P < 0.001) of the carotid artery. After adjusting for confounding factors that may influence IMT, A1C variability was significantly associated with the progression of IMT (r = 0.222, P = 0.034). However, the SD of A1C was not a significant independent risk factor for the progression of IMT in multiple regression analysis (beta = 0.158, P = 0.093). CONCLUSION: Higher A1C variability is associated with IMT progression in type 2 diabetic patients; however, it is not an independent predictor of IMT progression. Overall glycemic control is the most important factor in the progression of IMT.
RESUMO
BACKGROUND: We investigated the postoperative changes in visceral fat, as compared with subcutaneous fat in patients who underwent total gastrectomy (TG) or subtotal gastrectomy (STG). METHODS: Thirty-eight patients of gastric cancer who underwent abdominal and pelvic computed tomography scans before and after STG (n = 28) or TG (n = 10) were examined. The volumes of the total, visceral and subcutaneous adipose tissues (TAT, VAT and SAT, respectively) were calculated in each scan using the multislice method. Changes between the preoperative data and results obtained at 6 and 12 months after surgery were evaluated. RESULTS: In the first 6 months, there were significant decreases in TAT, VAT and SAT values in the TG (-2424 +/- 1309, -1535 +/- 1056 and -889 +/- 613 cm(3), respectively) and STG (-1590 +/- 1309, -1024 +/- 645, and -578 +/- 659 cm(3), respectively) groups. From 6 to 12 months after surgery, a further significant reduction in VAT (-351 +/- 196 cm(3)) in the TG group and significant regains in TAT and SAT (850 +/- 1205 and 757 +/- 1032 cm(3), respectively) in the STG group were observed. The ratio of VAT to SAT calculated in both groups decreased continuously in all periods of observation. CONCLUSION: Patients who underwent gastrectomy lost TAT, VAT and SAT during the postoperative period up to 6 months and the decrease in VAT was greater and more persistent than the decrease in SAT, particularly in the TG group.
