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OBJECTIVES: To introduce a new surgical mentorship, the "hand-grab navigated technique," to shorten the learning curve for Holmium laser enucleation of the prostate. METHODS: Patients with benign prostatic hyperplasia were managed at six institutions with Holmium laser enucleation of the prostate. An analysis was done in the 200 of these patients (the set of first 20 patients treated with Holmium laser enucleation of the prostate by 10 surgeons) who were sorted into two groups depending on the surgeon's instructional group. Surgeons in group I learned Holmium laser enucleation of the prostate by self-study by using videos and written information, whereas those in group II were instructed by "the hand-grab navigated technique" along with the self-study. To evaluate the efficiency of hand-grab navigated technique, enucleation and morcellation efficiencies between the two groups were compared. RESULTS: The mean prostate volume was 49.5 ± 23.8 and 51.1 ± 25.2 g in group I and II, respectively, showing no significant difference. The enucleation efficiency was significantly greater (P = 0.01) in group II (0.35 ± 0.20 g/min) than in group I (0.21 ± 0.12 g/min). Morcellation efficiency was also significantly greater (P = 0.03) in group II (3.08 ± 3.27 g/min) than in group I (2.43 ± 2.68 g/min). CONCLUSION: The learning curve for Holmium laser enucleation of the prostate can be shortened with the "hand-grab navigated technique" when combined with the self-study.
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Lasers de Estado Sólido/uso terapêutico , Curva de Aprendizado , Tutoria/métodos , Prostatectomia/educação , Hiperplasia Prostática/cirurgia , Idoso , Humanos , Masculino , Pessoa de Meia-Idade , Morcelação , Duração da Cirurgia , Prostatectomia/métodos , Ensino , Gravação em VídeoRESUMO
PURPOSE: To identify incidence and risk factors of recurrence after discontinuation of successful antimuscarinic therapy in patients with overactive bladder (OAB). MATERIALS AND METHODS: This was a prospective, multicenter trial. Patients who had antimuscarinic agents for more than 12 weeks and showed successful response were enrolled. Successful response was defined as answering 'benefit' for patient perception of treatment benefit and answer lesser than 3 points in patient's perception of bladder condition (PPBC). The enrolled patients discontinued the antimuscarinics, and we evaluated their recurrence with PPBC and OAB symptom score (OABSS) at 1, 3, 6, and 12 months. Primary purpose was to identify the recurrence rate and secondary purpose was to reveal risk factors. RESULTS: Four hundred forty-one patients enrolled and 371 patients completed 6-month follow-up. The enrolled patients showed 1.6 points in PPBC, 2.9 points in OABSS and 1.4 points in IPSS (quality of life) which represented successful response after using antimuscarinics. The cumulative rates of recurrence were 25.6%, 42.3%, and 52.2% at 1, 3, 6 months, respectively. Among 177 patients who did not show recurrence at 6 months, 41 patients were followed up and 4 patients of the 41 patients (9.7%) showed recurrence at 12 months. On univariate and multivariate analyses of recurrence, OAB wet was the risk factor for recurrence after 6 months of discontinuation. CONCLUSIONS: Discontinuation of antimuscarinic therapy after successful treatment resulted in high recurrence rate with time and OAB wet was the independent risk factor for recurrence.
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Antagonistas Muscarínicos/uso terapêutico , Bexiga Urinária Hiperativa/tratamento farmacológico , Idoso , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos Prospectivos , Qualidade de Vida , Recidiva , Fatores de Risco , Avaliação de Sintomas , Bexiga Urinária Hiperativa/complicações , Suspensão de TratamentoRESUMO
Ever since the ban on antibiotic growth promoters (AGPs), the livestock death rate has increased owing to pathogenic bacterial infections. There is a need of developing AGP alternatives; however, the mechanisms by which AGP enhances livestock growth performance are not clearly understood. In this study, we fed 3-week-old swine for 9 weeks with and without AGPs containing chlortetracycline, sulfathiazole, and penicillin to investigate the effects of AGPs on swine gut microbiota. Microbial community analysis was done based on bacterial 16S rRNA genes using MiSeq. The use of AGP showed no growth promoting effect, but inhibited the growth of potential pathogens during the early growth stage. Our results showed the significant increase in species richness after the stabilization of gut microbiota during the post-weaning period (4-week-old). Moreover, the swine gut microbiota was divided into four clusters based on the distribution of operational taxonomic units, which was significantly correlated to the swine weight regardless of AGP treatments. Taxonomic abundance analysis indicated a negative correlation between host weight and the abundance of the family Prevotellaceae species, but showed positive correlation to the abundance of the family Spirochaetaceae, Clostridiaceae_1, and Peptostreptococcaeae species. Although no growth performance enhancement was observed, the use of AGP inhibited the potential pathogens in the early growth stage of swine. In addition, our results indicated the ecological succession of swine gut microbiota according to swine weight. Here, we present a characterization of swine gut microbiota with respect to the effects of AGPs on growth performance.
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Ração Animal , Antibacterianos/farmacologia , Microbioma Gastrointestinal/efeitos dos fármacos , Animais , Biodiversidade , Peso Corporal , Análise por Conglomerados , Metagenoma , Filogenia , RNA Ribossômico 16S/genética , SuínosRESUMO
OBJECTIVE: This study aimed to retrospectively evaluate magnetic resonance imaging findings for the detection of lateral meniscocapsular separation (LMCS) in patients with tibial plateau fractures. We hypothesize that patients with LMCS have greater perimeniscal abnormal signal or greater distance between the lateral meniscus (LM) and the lateral collateral ligament (LCL) than patients without LMCS. METHODS: The study group included 16 patients with LMCS and 11 patients with normal LMCS who underwent surgery due to tibial plateau fracture. Magnetic resonance images were assessed for the width of perimeniscal abnormal signals on 3 orthogonal planes. The distance between LM and LCL was measured on coronal images. Nonparametric tests were performed. RESULTS: The thickness of perimeniscal abnormal signals was increased in the patient group than in control group (median, 10.00 [interquartile range, 9.00-12.70] mm vs 3.39 [2.45-3.67] mm at axial images [P < 0.001]; 8.60 [3.75-11.26] mm vs 2.73 [1.64-4.38] mm at coronal images [P = 0.015]; 13.57 [9.50-15.04] mm vs 4.65 [0-5.89] mm at sagittal images [P = 0.002], respectively). Sixteen patients in the patient group had involvement around the whole LM, whereas none of the patients in the control group had involvement around the whole LM (P < 0.001). The distance between LM and LCL was increased in the patient group than in the control group (9.00 [7.47-10.75] mm vs 5.11 [4.38-7.07] mm [P = 0.002], respectively). The cutoff value of 7 mm thickness of abnormal signal and distance between LM and LCL showed an accuracy of 96% (26/27 patients) and 85% (23/27 patients), respectively. CONCLUSIONS: Patients with perimeniscal signal greater than 7 mm or distance between LM and LCL greater than 7 mm have high likelihood of LMCS.
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Imageamento por Ressonância Magnética , Meniscos Tibiais/patologia , Fraturas da Tíbia/complicações , Lesões do Menisco Tibial , Adulto , Idoso , Idoso de 80 Anos ou mais , Feminino , Humanos , Articulação do Joelho , Masculino , Pessoa de Meia-Idade , Estudos Retrospectivos , Adulto JovemRESUMO
BACKGROUND: The purpose of this study was to investigate the presence of intercellular adhesion molecule-1 (ICAM-1) in shoulders with adhesive capsulitis ("frozen shoulder"). METHODS: Glenohumeral capsular tissue was obtained from twenty-six patients (seventeen with adhesive capsulitis and nine controls), and ICAM-1 was evaluated with use of oligonucleotide arrays, real-time reverse transcription-polymerase chain reaction (RT-PCR), and immunohistochemistry. ICAM-1 was also evaluated in synovial fluid with use of western blotting (six patients with adhesive capsulitis and two controls) and in peripheral blood with use of an enzyme-linked immunosorbent assay (ELISA) (thirty-two patients with adhesive capsulitis, twenty with diabetes mellitus, and fourteen controls). The effect of ICAM-1 treatment on gene expression of cytokines related to inflammation and fibrosis was evaluated in cultured normal human synovial cells. RESULTS: The level of ICAM-1 was significantly greater in capsular tissue from the glenohumeral joint of patients with adhesive capsulitis compared with controls as measured by oligonucleotide array analysis (0.12 ± 0.01 compared with 0.09 ± 0.00 arbitrary units) (p = 0.001), real-time RT-PCR (1.70 ± 0.19 compared with 0.67 ± 0.24 arbitrary units) (p < 0.05), and immunohistochemical staining. ICAM-1 was also significantly increased in the synovial fluid of patients with adhesive capsulitis (1.70 ± 0.18 arbitrary units) compared with normal controls (0.48 ± 0.17) (p < 0.05) and in serum of patients with adhesive capsulitis (633.22 ± 59.14 ng/mL) and patients with diabetes mellitus (671.25 ± 27.08 ng/mL) compared with controls (359.86 ± 44.29 ng/mL) (p < 0.05). Gene expression of cytokines related to inflammation and fibrosis in synoviocytes cultured in vitro was greater after three days of treatment with ICAM-1 and with ICAM-1 with glucose compared with untreated cells. CONCLUSIONS: ICAM-1 was increased in patients with adhesive capsulitis, similar to the increase that has been reported in patients with diabetes mellitus.
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Bursite/metabolismo , Molécula 1 de Adesão Intercelular/metabolismo , Articulação do Ombro/metabolismo , Adulto , Western Blotting , Estudos de Casos e Controles , Ensaio de Imunoadsorção Enzimática , Feminino , Humanos , Imuno-Histoquímica , Masculino , Pessoa de Meia-Idade , Análise de Sequência com Séries de Oligonucleotídeos , Reação em Cadeia da Polimerase em Tempo Real , Estatísticas não ParamétricasRESUMO
PURPOSE: To compare the accuracy of ultrasonography and MR arthrography (MRA) imaging in detecting of rotator cuff tears with arthroscopic finding used as the reference standard. METHODS: The ultrasonography and MRA findings of 51 shoulders that underwent the arthroscopic surgery were prospectively analysed. Two orthopaedic doctors independently performed ultrasonography and interpreted the findings at the office. The tear size measured at ultrasonography and MRA was compared with the size measured at surgery using Pearson correlation coefficients (r). The sensitivity, specificity, accuracy, positive predictive value, negative predictive value and false-positive rate were calculated for a diagnosis of partial-and full-thickness rotator cuff tears. The kappa coefficient was calculated to verify the inter-observer agreement. RESULTS: The sensitivity of ultrasonography and MRA for detecting partial-thickness tears was 45.5 and 72.7 %, and that for full-thickness tears was 80.0 and 100 %, respectively. The accuracy of ultrasonograpy and MRA for detecting partial-thickness tears was 45.1 and 88.2 %, and that for full-thickness tears was 82.4 and 98 %, respectively. Tear size measured based on ultrasonography examination showed a poor correlation with the size measured at arthroscopic surgery (r = 0.21; p < 0.05). However, tear size estimated by MRA showed a strong correlation (r = 0.75; p < 0.05). The kappa coefficient was 0.47 between the two independent examiners. CONCLUSIONS: The accuracy of office-based ultrasonography for beginner orthopaedic surgeons to detect full-thickness rotator cuff tears was comparable to that of MRA but was less accurate for detecting partial-thickness tears and torn size measurement. Inter-observer agreement on the interpretation was fair. These results highlight the importance of the correct technique and experience in operation of ultrasonography in shoulder joint. LEVEL OF EVIDENCE: Diagnostic study, Level II.
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Curva de Aprendizado , Lesões do Manguito Rotador , Manguito Rotador/diagnóstico por imagem , Artroscopia , Feminino , Humanos , Imageamento por Ressonância Magnética , Masculino , Consultórios Médicos , Valor Preditivo dos Testes , Estudos Prospectivos , Sensibilidade e Especificidade , UltrassonografiaRESUMO
A 71-year-old man was referred for painless hematuria and a bladder tumor. Cystoscopy and computed tomography revealed a 3-cm oval nodular mass on the left lateral side of the bladder. The patient underwent a complete transurethral resection of the lesion and histology showed a proliferation of atypical spindle cells with inflammation consistent with a myofibroblastic tumor. After 4 and 7 months, follow-up cystoscopy demonstrated nodular mass lesions and transurethral resection of bladder tumor was done, which showed chronic cystitis and a recurred myofibroblastic tumor, respectively. Five months later, multiple lymph node, bone, and soft tissue metastases were found by positron emission tomography. The patient was treated first with palliative chemotherapy, including doxorubicin and cisplatin. After that, radiologic studies showed disease progression but the patient refused further treatment and died 6 months later.
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Maximal oxygen uptake is generally accepted as the most valid and reliable index of cardiorespiratory fitness and functional aerobic capacity. The exercise test for measuring maximal oxygen uptake is unsuitable for screening tests in public heath examinations, because of the potential risks of exercise exertion and time demands. We designed this study to determine whether work-related physical activity is a potential predictor of maximal oxygen uptake, and to develop a maximal oxygen uptake equation using a non-exercise regression model for the cardiorespiratory fitness test in Korean adult workers. Study subjects were adult workers of small-sized companies in Korea. Subjects with history of disease such as hypertension, diabetes, asthma and angina were excluded. In total, 217 adult subjects (113 men of 21-55 years old and 104 women of 20-64 years old) were included. Self-report questionnaire survey was conducted on study subjects, and maximal oxygen uptake of each subject was measured with the exercise test. The statistical analysis was carried out to develop an equation for estimating maximal oxygen uptake. The predictors for estimating maximal oxygen uptake included age, gender, body mass index, smoking, leisure-time physical activity and the factors representing work-related physical activity. The work-related physical activity was identified to be a predictor of maximal oxygen uptake. Moreover, the equation showed high validity according to the statistical analysis. The equation for estimating maximal oxygen uptake developed in the present study could be used as a screening test for assessing cardiorespiratory fitness in Korean adult workers.
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Emprego , Teste de Esforço , Saúde , Consumo de Oxigênio/fisiologia , Adulto , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , República da Coreia , Recursos Humanos , Adulto JovemRESUMO
OBJECTIVE: The purpose of our study was to compare the accuracy of 3D fat-suppressed isotropic turbo spin-echo (TSE) sequences using sampling perfection with application-optimized contrasts using different flip angle evolution (SPACE) with 2D conventional MRI at 3 T in determining meniscal tear types. MATERIALS AND METHODS: Sixty-nine patients with arthroscopically confirmed meniscal tears underwent MRI with 2D sequences and 3D TSE SPACE. Images were retrospectively analyzed by two reviewers and correlated with arthroscopic findings. Meniscal tears were classified into one of eight types: horizontal, longitudinal, radial, root, flap, oblique, complex, and bucket-handle. For every type of tear, sensitivity, specificity, and interobserver agreement were calculated. RESULTS: Mean sensitivities and specificities on 3D TSE SPACE versus 2D sequences were as follows: for radial tears, 77% and 93% versus 68% and 90%; for flap tears, 73% and 96% versus 54% and 85%; for horizontal tears, 85% and 91% versus 78% versus 87%; for longitudinal tears, 50% and 97% versus 72% and 96%; and for root tears, 88% and 99% versus 81% and 99%. The specificity for flap tears was statistically higher on 3D TSE SPACE than 2D sequences. Interobserver agreements were higher on 3D TSE SPACE than 2D sequences for radial, flap, and longitudinal tears. CONCLUSION: In categorizing meniscal tears, 3D TSE SPACE has higher specificity for flap tears than 2D conventional sequences. However, there is no significant difference between 2D conventional sequences and 3D TSE SPACE except for flap tears.
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Imageamento Tridimensional , Traumatismos do Joelho/diagnóstico , Imageamento por Ressonância Magnética/métodos , Lesões do Menisco Tibial , Adolescente , Adulto , Idoso , Idoso de 80 Anos ou mais , Artroscopia , Meios de Contraste , Feminino , Humanos , Traumatismos do Joelho/cirurgia , Masculino , Meniscos Tibiais/cirurgia , Pessoa de Meia-Idade , Estudos Retrospectivos , Sensibilidade e EspecificidadeRESUMO
PURPOSE: The aim of this study was to evaluate the clinical and structural outcome of the new fixation technique of type-II SLAP repair using double anchors compared with conventional method. METHODS: Twenty-eight patients with 29 shoulders, who were followed up for at least 1 year after surgery, were enrolled. Fourteen shoulders were treated using the new technique (group 1), and 15 shoulders using the conventional technique (group 2). The clinical outcomes were evaluated using two different functional scores, the pain VAS and range of motion. The postoperative labral integrity was determined by magnetic resonance imaging at 1 year after surgery. RESULTS: At postoperative 6 months, all functional scores of group 1 were superior to group 2, particularly in pain VAS and Constant Scoring System. All ranges of motion in group 1 showed a better result than in group 2, particularly in forward flexion and external rotation at 90° abduction (88° ± 4.8 in group 1 and 84° ± 9.2 in group 2, P = 0.03). At postoperative 12 months and the last visit, all functional scores in group 1 were superior to those in group 2 and all external rotations at 90° of abduction in group 1 showed significantly better results than those of group 2. All patients in group 1 showed complete healing of the repaired SLAP lesion but one patient in group 2 showed partial detachments on the MRI. CONCLUSIONS: This new technique provides anatomical restoration of a SLAP lesion and yields successful clinical and structural outcomes at a short-term follow-up. LEVEL OF EVIDENCE: Randomized controlled trials, level II.
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Artroscopia/métodos , Cartilagem Articular/lesões , Lesões do Ombro , Âncoras de Sutura , Adulto , Idoso , Artroscopia/instrumentação , Artroscopia/reabilitação , Cartilagem Articular/fisiologia , Cartilagem Articular/cirurgia , Feminino , Seguimentos , Cavidade Glenoide , Humanos , Masculino , Pessoa de Meia-Idade , Medição da Dor , Estudos Prospectivos , Amplitude de Movimento Articular , Recuperação de Função Fisiológica , Articulação do Ombro/fisiologia , Articulação do Ombro/cirurgia , Resultado do TratamentoRESUMO
OBJECTIVES: This study investigated the relationship between the blood mercury concentration and cardiovascular risk factors in elderly Korean individuals living in coastal areas. METHODS: The sample consisted of 477 adults (164 males, 313 females) aged 40 to 65 years who visited a Busan health promotion center from June to September in 2009. The relationship between blood mercury concentration and cardiovascular risk factors including metabolic syndrome, cholesterol profiles, blood pressure, body mass index (BMI), waist circumference and waist-to-hip ratio (WHR), was investigated. Variables related to blood mercury concentration were further evaluated using multiple regression analysis. RESULTS: The blood mercury concentration of the study population was 7.99 (range, 7.60 to 8.40) µg/L. In males, the blood mercury concentration was 9.74 (8.92 to 10.63) µg/L, which was significantly higher than that in females (7.21, [6.80 to 7.64] µg/L). The blood mercury concentration of the study population was related to several cardiovascular risk factors including low-density lipoprotein (LDL) cholesterol (p=0.044), high-density lipoprotein (HDL) cholesterol (p=0.034), BMI (p=0.006), waist circumference (p=0.031), and WHR (p<0.001). In males, the blood mercury concentration was significantly correlated with WHR in the multiple regression analysis. CONCLUSIONS: In males, the blood mercury concentration was related to waist-to-hip ratio, which is a central obesity index and cardiovascular risk factor. Our finding suggests that cardiovascular disease risk in males was increased by mercury exposure via an obesity-related mechanism.
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Mercúrio/sangue , Relação Cintura-Quadril , Adulto , Idoso , Povo Asiático , Índice de Massa Corporal , Doenças Cardiovasculares/sangue , Doenças Cardiovasculares/etiologia , HDL-Colesterol/sangue , LDL-Colesterol/sangue , Feminino , Humanos , Entrevistas como Assunto , Masculino , Pessoa de Meia-Idade , Análise de Regressão , República da Coreia , Fatores de Risco , Inquéritos e Questionários , Circunferência da CinturaRESUMO
Limited data exist regarding why delaminated tears occur within the rotator cuff tendon, and no general agreement exists on how to handle this complicated tear. To analyze in vivo intratendinous strain of the supraspinatus tendon, the superficial, middle, and deep regions were marked with speckles using 2D speckle tracking echocardiography (2D STE) of 15 shoulders. The displacement and the strain of each speckle during isotonic and isometric shoulder motion were evaluated. Significantly different displacement and strains in the tendon were found between isometric and isotonic shoulder motions. In isometric motion, the average longitudinal displacement of the speckle at the superficial region (1.66 mm) was larger than at the deep region (0.61 mm), and the average peak strain at the superficial region (17.03%) was also higher than that at the deep region (3.42%). Conversely, in isotonic motion, the average longitudinal displacement of the speckle at the superficial region (0.70 mm) was less than that at the deep region (1.61 mm), and the average peak strain at the superficial region (4.73%) was also lower than that at the deep region (15.69%). A different strain was found between the superficial and deep regions within the intact live supraspinatus tendon. The strain and displacement patterns vary according to isometric versus isotonic shoulder motions. On the basis of our observations, we suggest that the delaminated tear of the rotator cuff tendon must be repaired separately layer by layer to resist the inhomogeneous strain after the repair.
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Ecocardiografia/métodos , Ecocardiografia/normas , Manguito Rotador/diagnóstico por imagem , Manguito Rotador/fisiologia , Adulto , Humanos , Contração Isométrica/fisiologia , Contração Isotônica/fisiologia , Masculino , Músculo Esquelético/fisiologia , Valores de Referência , Lesões do Manguito Rotador , Articulação do Ombro/diagnóstico por imagem , Articulação do Ombro/fisiologia , Estresse MecânicoRESUMO
OBJECTIVE: To prospectively evaluate the diagnostic accuracy of proton density-weighted imaging with and without fat suppression for detecting meniscal tears. MATERIALS AND METHODS: The study involved 48 patients who underwent arthroscopy less than 3 months after proton density-weighted imaging with and without fat suppression. Sagittal images were independently reviewed by two radiologists for the presence of meniscal tears. Medial and lateral menisci were separately analyzed in terms of anterior horn, body, and posterior horn. Interobserver agreement was assessed using κ coefficients. The McNemar test was used to determine any differences between the two methods in terms of sensitivity and specificity. Arthroscopy findings were used as the diagnostic reference standard. RESULTS: Arthroscopy revealed 71 tears involving 85 meniscal segments: 34 medial meniscal segments and 51 lateral meniscal segments. The sensitivity, specificity, and accuracy of each radiologist were 95% (81/85), 92% (186/203), and 93% (267/288), and 93% (79/85), 93% (189/203), and 93% (268/288) when using fat-suppressed proton density-weighted imaging, and 91% (77/85), 93% (189/203), and 92% (266/288), and 91% (77/85), 93% (188/203), and 92% (265/288) when using proton density-weighted imaging without fat suppression, respectively. Interobserver agreement for meniscal tears was very high with proton-weighted imaging with (κ = 0.87) or without (κ = 0.86) fat suppression. There were no significant differences for detection of medial meniscal tears when using proton density-weighted imaging with or without fat suppression for both readers (p > 0.05). CONCLUSION: Fat-suppressed proton density-weighted imaging can replace proton density-weighted imaging without fat suppression for the detection of meniscal tears.
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Tecido Adiposo/patologia , Aumento da Imagem/métodos , Imageamento por Ressonância Magnética/métodos , Meniscos Tibiais/patologia , Técnica de Subtração , Lesões do Menisco Tibial , Adolescente , Adulto , Idoso , Feminino , Humanos , Traumatismos do Joelho/patologia , Traumatismos do Joelho/cirurgia , Masculino , Meniscos Tibiais/cirurgia , Pessoa de Meia-Idade , Prótons , Sensibilidade e Especificidade , Adulto JovemRESUMO
PURPOSE: The prognostic significance of perineural invasion by prostate cancer is debated. We investigated the association between perineural invasion and clinicopathological factors and the effect of perineural invasion on survival in patients with prostate cancer. MATERIALS AND METHODS: A total of 361 patients with prostate cancer without any neoadjuvant therapies prior to surgery from 1999 to 2010 were analyzed retrospectively. Whole-mount sections of surgical specimens from all patients who underwent radical prostatectomy were evaluated. Positive perineural invasion was defined as infiltration of cancer cells in the perineurium or neural fascicles. The relationship of perineural invasion with clinicopathological features and prognosis of prostate cancer was studied. We also researched preoperative factors that were associated with perineural invasion. RESULTS: Perineural invasion in a prostatectomy specimen (PNIp) was positive in 188 of 361 patients (52.1%). In the multivariate analysis of the preoperative variables, PNIp was related to the primary Gleason grade (p=0.020), the number of positive cores (p=0.008), and the percentage of tumor cells in positive cores (p=0.021), but not to perineural invasion of a prostate biopsy. In the evaluation between PNIp and pathologic findings of the prostatectomy specimen, PNIp was related to the Gleason score (p=0.010), T-stage (p=0.015), and lymphovascular invasion (p=0.019). However, by multivariate analysis, the PNIp was not an independent prognostic factor of biochemical serum recurrence (p=0.364) or cancer-specific survival (p=0.726). CONCLUSIONS: PNIp was significantly related to biologically aggressive tumor patterns but was not a prognostic factor for biochemical serum PSA recurrence or cancer-specific survival in patients with prostate cancer.
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BACKGROUND: Fat-suppressed (FS) proton density (PD)-weighted magnetic resonance imaging (MRI) and FS three-dimensional (3D) gradient-echo imaging such as spoiled gradient-recalled (SPGR) sequence have been established as accurate methods for detecting articular cartilage defects. PURPOSE: To retrospectively compare the diagnostic efficacy between FS PD-weighted and FS 3D gradient-echo MRI for differentiating between grade 3 and grade 4 cartilage defects of the knee with arthroscopy as the standard of reference. MATERIAL AND METHODS: Twenty-one patients who had grade 3 or 4 cartilage defects in medial femoral condyle at arthroscopy and knee MRI were included in this study: grade 3, >50% cartilage defects; grade 4, full thickness cartilage defects exposed to the bone. Sagittal FS PD-weighted MR images and FS 3D gradient-echo images with 1.5 T MR images were independently graded for the cartilage abnormalities of medial femoral condyle by two musculoskeletal radiologists. Statistical analysis was performed by Fisher's exact test. Inter-observer agreement in grading of cartilage was assessed using kappa coefficients. RESULTS: Arthroscopy revealed grade 3 defects in 17 patients and grade 4 defects in 4 patients in medial femoral condyles. For FS 3D gradient-echo images grade 3 defects were graded as grade 3 (n=15) and grade 4 (n=2), and all grade 4 defects (n=4) were correctly graded. However, for FS PD-weighted MR images all grade 3 defects were misinterpreted as grade 1 (n=1) and grade 4 (n=16), whereas all grade 4 defects (n=4) were correctly graded. FS 3D gradient-echo MRI could differentiate grade 3 from grade 4 defects (P=0.003), whereas FS PD-weighted imaging could not (P=1.0). Inter-observer agreement was substantial (kappa=0.70) for grading of cartilage using FS PD-weighted imaging, whereas it was moderate (kappa=0.46) using FS 3D gradient-echo imaging. CONCLUSION: FS 3D gradient-echo MRI is more helpful for differentiating between grade 3 and grade 4 cartilage defects than is FS PD-weighted imaging.
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Doenças das Cartilagens/diagnóstico , Cartilagem Articular/patologia , Imageamento Tridimensional , Articulação do Joelho/patologia , Imageamento por Ressonância Magnética/métodos , Idoso , Artroscopia , Diagnóstico Diferencial , Feminino , Humanos , Masculino , Pessoa de Meia-Idade , Estudos RetrospectivosRESUMO
The purpose of this study was to evaluate the effect of changing activity after total knee arthroplasty (TKA) on metabolic syndrome with a follow-up period of 2 years. Two hundred consecutive patients who were to undergo TKA were prospectively enrolled. The patients' blood pressure, fasting plasma glucose level, the lipid profile, the waist circumference, the Knee Society score, and the Lower Extremity Activity Scale were measured preoperatively and at the 2-year follow-up visit. The data from 169 patients were finally collected and reviewed. Two years after primary TKA, there was no change in the prevalence of metabolic syndrome, despite that the patients had a significant increase of their physical activity.
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Artroplastia do Joelho , Síndrome Metabólica/epidemiologia , Osteoartrite do Joelho/cirurgia , Idoso , Idoso de 80 Anos ou mais , Glicemia/metabolismo , Pressão Sanguínea/fisiologia , Feminino , Seguimentos , Humanos , Lipídeos/sangue , Masculino , Síndrome Metabólica/sangue , Síndrome Metabólica/fisiopatologia , Pessoa de Meia-Idade , Atividade Motora/fisiologia , Osteoartrite do Joelho/fisiopatologia , Prevalência , Estudos ProspectivosRESUMO
BACKGROUND: Robotic surgery for rectal cancer may be a way to overcome the limitations of laparoscopic surgery. However, totally robotic surgery for rectal cancer is still technically challenging. This report describes the technical details and outcomes of totally robotic rectal surgery. METHODS: The authors developed a totally robotic surgery technique for rectal cancer and performed it for 45 patients. We designed a six-port system, including a camera port, to perform rectal cancer surgery from the splenic flexure to the pelvic diaphragm in one setup. To check the feasibility and safety of the procedure, perioperative outcomes including conversion rate, morbidity, and mortality were analyzed. RESULTS: The mean body mass index of the 45 patients was 23.6 kg/m(2) (range, 18.8-31.6 kg/m(2)). There was one case (2.2%) of conversion to laparotomy because of a common iliac artery injury. The 30-day morbidity rate was 11.1%. There was no operation-related mortality. CONCLUSIONS: Totally robotic surgery for rectal cancer using the described technique was feasible and safe. This result could facilitate the spread of robotic surgery for rectal cancer and maximize the advantages of robotic surgery.
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Laparoscopia/métodos , Neoplasias Retais/cirurgia , Robótica/instrumentação , Adulto , Idoso , Idoso de 80 Anos ou mais , Colo Transverso/cirurgia , Estudos de Viabilidade , Feminino , Humanos , Laparoscopia/mortalidade , Masculino , Pessoa de Meia-Idade , Diafragma da Pelve/cirurgia , Complicações Pós-Operatórias , Neoplasias Retais/mortalidade , Resultado do TratamentoRESUMO
The authors investigated the agreements between three different methods of estimating gap balance in cruciate-retaining (CR) total knee arthroplasty (TKA) with the use of a subvastus approach. One hundred consecutive CR TKAs were prospectively included in this study. After completing soft tissue release and bone cutting for CR TKA, flexion-extension gap balance was assessed using a distractor, spacer blocks, and trial components. Levels of agreement between the estimation techniques used were substantial. All three techniques were reliable in the assessment of gap balance. But, observations made during this study suggest that if more than one estimation technique is applied during CR TKA, the incidence of undetected gap imbalance can be reduced.
Assuntos
Artroplastia do Joelho , Articulação do Joelho/anatomia & histologia , Articulação do Joelho/fisiologia , Amplitude de Movimento Articular , Idoso , Idoso de 80 Anos ou mais , Fenômenos Biomecânicos , Estudos de Coortes , Feminino , Humanos , Masculino , Pessoa de Meia-IdadeRESUMO
With the exception of flexion gap tightness, which is common in cruciate-retaining (CR) total knee arthroplasty (TKA), the risk factors of flexion gap tightness have not been described. This retrospective study characterized factors that are associated with flexion gap tightness in CR TKA. Data on 203 consecutive knees that underwent CR TKA were reviewed. The prevalence rate of flexion gap tightness was 21.1%. By logistic regression analysis after adjusting for age, preoperative flexion contracture, and referencing method used for femoral sizing, insufficient tibial slope remained a significant independent risk factor of flexion gap tightness. Although excessive tibial slope should be avoided, the findings of the present study demonstrate that the risk of flexion gap tightness can be reduced by increasing the tibial slope in CR TKA.