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1.
Discov Med ; 36(184): 1002-1011, 2024 May.
Artigo em Inglês | MEDLINE | ID: mdl-38798259

RESUMO

BACKGROUND: Tuberculosis (TB) is still the main cause of mortality due to a single transfectant, Mycobacterium tuberculosis (MTB). Latent tuberculosis infection (LTBI) is a condition characterized by the presence of tuberculosis (TB) that is not clinically apparent but nonetheless shows a sustained response to MTB. Presently, tuberculin skin test (TST) and interferon gamma (IFN-γ) release assays (IGRAs) are mainly used to detect LTBI via cell-mediated immunity of T-cells. For people with end-stage renal disease (ESRD), the diagnosis of patients infected with MTB is difficult because of T-cell dysfunction. To get more accurate diagnosis results of LTBI, it must compensate for the deficiency of IGRA tests. METHODS: Sixty-seven hemodialysis (HD) patients and 96 non-HD patients were enrolled in this study and the study population is continuously included. IFN-γ levels were measured by the QuantiFERON-TB Gold In-Tube (QFT-GIT) test. Kidney function indicators, blood urea nitrogen (BUN), serum creatinine (Cr), and estimated glomerular filtration rate (eGFR) were used to compensate for the declined IFN-γ levels in the IGRA test. RESULTS: In individuals who were previously undetected, the results of compensation with serum Cr increased by 10.81%, allowing for about 28% more detection, and compensation with eGFR increased by 5.41%, allowing for approximately 14% more detectable potential among them and employing both of them could enhance the prior shortcomings of IGRA tests. when both are used, the maximum compensation results show a sensitivity increase rate of 8.81%, and approximately 23% of patients who were previously undetectable may be found. CONCLUSION: Therefore, the renal function markers which are routine tests for HD patients to compensate for the deficiency of IGRA tests could increase the accuracy of LTBI diagnosis.


Assuntos
Testes de Liberação de Interferon-gama , Falência Renal Crônica , Tuberculose Latente , Diálise Renal , Humanos , Tuberculose Latente/diagnóstico , Tuberculose Latente/imunologia , Tuberculose Latente/sangue , Masculino , Feminino , Pessoa de Meia-Idade , Diálise Renal/efeitos adversos , Testes de Liberação de Interferon-gama/métodos , Falência Renal Crônica/terapia , Falência Renal Crônica/complicações , Falência Renal Crônica/sangue , Falência Renal Crônica/imunologia , Idoso , Interferon gama/sangue , Adulto , Reações Falso-Negativas , Taxa de Filtração Glomerular , Creatinina/sangue , Mycobacterium tuberculosis/imunologia , Teste Tuberculínico/métodos , Nitrogênio da Ureia Sanguínea
2.
Psychiatry Investig ; 20(12): 1148-1156, 2023 Dec.
Artigo em Inglês | MEDLINE | ID: mdl-38163654

RESUMO

OBJECTIVE: The discrepancy between desired time in bed and desired total sleep time (DBST index) is correlated with the severity of insomnia among the general population. This study aimed to explore whether the change in DBST index is associated with changes in insomnia severity. METHODS: The study was conducted as a single source tracking online survey among the general population. The first survey (T1) was completed by all 399 participants, and the second survey (T2) was completed by 233 participants 5-6 weeks after the T1 survey with a simple instruction of reducing the DBST index. Participants' age, sex, marital status, past psychiatric history, and sleep patterns were collected. In addition to the DBST index, the Glasgow Sleep Effort Scale (GSES), Dysfunctional Beliefs about Sleep-2 items (DBS-2), and Insomnia Severity Index (ISI) were rated. RESULTS: The change in the ISI (T1-T2) was significantly correlated with the changes in the GSES (r=0.24, p<0.001), DBS-2 (r=0.22, p<0.001), and DBST index (r=0.15, p=0.020). The change in insomnia severity was expected with change in the GSES (ß=0.23, p<0.001), DBS-2 (ß=0.20, p=0.002), and DBST index (ß=0.13, p=0.037). Mediation analysis showed that change in DBST index directly influenced change in insomnia severity and change in GSES or DBS-2 did not mediate the relationship. CONCLUSION: Changing the DBST index can be a simple way to reduce insomnia severity among the general population.

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