RESUMO
The purpose of this study is to examine the validity and reproducibility of impedance body fat measurement devices measuring the body composition of Korean male and female adults using three bioelectrical impedance analyzers. We compared two methods for evaluating body composition: dual energy X-ray absorptiometry (DEXA), and bioelectrical impedance analysis (BIA). Subjects were 200 healthy adult Korean males and females whose mean±standard deviation (range) age, standing height, body weight, and body mass index (BMI) were 44.1±14.5 years, 172.8±7.4 cm, 76.0±12.8 kg, and 25.4±3.3 kg/m2, and 44.5±14.7 years, 158.7±5.8 cm, 58.3±8.3 kg, and 23.2±3.0 kg/m2, respectively. As a result, first of all, the reproducibility of the bioelectrical impedance analyzer had very high coefficients at r=0.998, r=0.997 between men and women, respectively. The correlation coefficients among three comparisons for lean body mass (LBM) were provided the following coefficients: r=0.951 for DEXA vs. ACCUNIQ BC720, r=0.950 for DEXA vs. ACCUNIQ BC360, and r=0.946 for DEXA vs. ACCUNIQ BC380 in men. In the results for women, they also had the very high following coefficients: r=0.956 for DEXA vs. ACCUNIQ BC720, r=0.946 for DEXA vs. ACCUNIQ BC360, and r=0.957 for DEXA vs. ACCUNIQ BC380 in LBM. In conclusion, this research showed a higher correlation in terms of accuracy compared to existing BIA-based body composition measurement techniques, and the accuracy of LBM was improved with high correlation coefficients through the algorithm that was improved using the multifrequency BIA method in the ACCUNIQ BC products.
RESUMO
PURPOSE: Overactive bladder (OAB) causes urinary urgency, usually accompanied by frequency and nocturia. Alpha 1-adrenergic receptor (α1-AR) antagonists are known to improve lower urinary tract symptoms associated with OAB. The α1-AR antagonists constitute a variety of drugs according to the receptor subtype affinity. This study investigated the efficacy of tamsulosin, naftopidil, and a combination of the two on OAB rats. METHODS: The OAB rat model was induced by an intraperitoneal injection of cyclophosphamide for 14 days. The experimental groups were divided into 5 groups: control group, OAB-induction group, OAB-induction and tamsulosin monotherapy group, OAB-induction and naftopidil monotherapy group, and OAB-induction and tamsulosin-naftopidil combination therapy group. For the drug-treated groups, each drug was administrated for 14 days after the OAB induction. Cystometry for urodynamic evaluation and immunohistochemical stain for c-Fos and nerve growth factor (NGF) expressions in the central micturition centers were performed. RESULTS: Increased contraction pressure and time with enhanced c-Fos and NGF expressions in the central micturition centers were found in the OAB rats. Tamsulosin suppressed contraction pressure and time while inhibiting c-Fos and NGF expressions. Naftopidil showed no significant effect and combination therapy showed less of an effect on contraction pressure and time. Naftopidil and combination therapy exerted no significant effect on the c-Fos and NGF expressions. CONCLUSIONS: Tamsulosin showed the most prominent efficacy for the treatment of OAB compared to the naftopidil and combination. The combination of tamsulosin with naftopidil showed no synergistic effects on OAB; however, further studies of addon therapy might provide opportunities to find a new modality.
