1.
Biochem Biophys Res Commun
; 366(1): 23-8, 2008 Feb 01.
Artigo
em Inglês
| MEDLINE
| ID: mdl-18036554
RESUMO
The present study shows that rat liver and brain mitochondrial nitric oxide synthase (mtNOS) are functionally associated with mitochondrial respiratory chain complex I. When complex I is activated, mtNOS exerts high activity and generates nitric oxide, whereas inactivation of complex I leads mtNOS to abandon its NOS activity. Functional association of mtNOS with complex I is potentially important in regulating mtNOS activity and mitochondrial functions.