1.
Bioorg Med Chem Lett
; 15(20): 4589-93, 2005 Oct 15.
Artigo
em Inglês
| MEDLINE
| ID: mdl-16115767
RESUMO
Structure-activity relationship studies leading to the discovery of novel mGlu5 receptor antagonists are described. These compounds show high in vitro potency, have good in vivo receptor occupancy, and a reasonable intravenous pharmacokinetic profile.