1.
Bioorg Med Chem Lett
; 14(3): 783-6, 2004 Feb 09.
Artigo
em Inglês
| MEDLINE
| ID: mdl-14741289
RESUMO
Bis-aryl ureas have been disclosed previously as a potent class of Raf kinase inhibitors. Modifications in the amide portion led to an improvement in aqueous solubility, an important characteristic for an oral drug. Based on this finding, we hypothesize that this portion of the molecule is directed towards the solvent in Raf-1.