RESUMO
Hyperbaric oxygen therapy (HBO) is used to treat some complications of head and neck carcinoma treatment. Several patients treated with HBO have had rapid growth of a clinically cured squamous cell carcinoma. Prior studies have produced conflicting evidence about the effect of HBO on tumor growth. This study was undertaken to determine the effects of HBO on established squamous cell carcinoma. Forty Golden Syrian hamster cheek-pouch carcinomas were induced with the established chemical carcinogen 9,10-dimethyl-1,2-benzanthracene. Twenty hamsters underwent 30 HBO dives for 60 minutes each to 2.81 atm, while 20 served as controls. At necropsy, animals receiving HBO therapy had significantly smaller tumors (P < .05) and showed a trend toward fewer cervical metastases (P < .06). HBO therapy with coexistent carcinoma inhibited the established tumor's growth.
Assuntos
Carcinoma de Células Escamosas/terapia , Oxigenoterapia Hiperbárica , Mucosa Bucal , Neoplasias Bucais/terapia , Animais , Carcinoma de Células Escamosas/patologia , Bochecha , Cricetinae , Estudos de Avaliação como Assunto , Mesocricetus , Neoplasias Bucais/patologia , Metástase Neoplásica , Fatores de TempoRESUMO
Here we review the role of angiogenesis as it pertains to the interactions between the epithelium and the mesenchyme, especially during tumor growth and metastasis. We illustrate and discuss several models of angiogenesis including endothelial tube formation on Matrigel. Finally, we examine angiogenic factors using the Matrigel model and investigate several other matrix molecules for their importance in angiogenesis and epithelial/stromal interactions.
Assuntos
Mesoderma/fisiologia , Neoplasias/irrigação sanguínea , Neoplasias/patologia , Neovascularização Patológica/fisiopatologia , Animais , Diferenciação Celular , Divisão Celular , Células Cultivadas , Colágeno , Combinação de Medicamentos , Células Epiteliais , Epitélio/patologia , Epitélio/fisiologia , Matriz Extracelular/fisiologia , Substâncias de Crescimento/fisiologia , Humanos , Laminina/fisiologia , Mesoderma/patologia , Modelos Biológicos , Metástase Neoplásica , Neoplasias/fisiopatologia , Proteoglicanas , Células Tumorais CultivadasRESUMO
The authors found that four measures of legal pressure were either unrelated or negatively related to retention and outcome in five drug abuse treatment modalities. This suggests that nonvolunteer clients are likely to be insufficiently motivated to benefit fully from treatment and their presence may adversely affect staff morale and prognosis of volunteer clients. The authors recommend that legal pressure not be used as a basis for assigning applicants to treatment modalities and suggest that treatment outcome might be improved by procedures that 1) deal clinically with motivational differences between volunteers and nonvolunteers, 2) establish stricter motivational criteria for admitting nonvolunteers, or 3) encourage enforcement of existing sanctions against violations of stipulations to treatment.
