RESUMO
Simple urea compounds ("phurealipids") have been identified from the entomopathogenic bacterium Photorhabdus luminescens, and their biosynthesis was elucidated. Very similar analogues of these compounds have been previously developed as inhibitors of juvenile hormone epoxide hydrolase (JHEH), a key enzyme in insect development and growth. Phurealipids also inhibit JHEH, and therefore phurealipids might contribute to bacterial virulence.
Assuntos
Produtos Biológicos/farmacologia , Inibidores Enzimáticos/farmacologia , Epóxido Hidrolases/antagonistas & inibidores , Photorhabdus/química , Ureia/farmacologia , Animais , Produtos Biológicos/química , Produtos Biológicos/metabolismo , Inibidores Enzimáticos/química , Inibidores Enzimáticos/metabolismo , Epóxido Hidrolases/metabolismo , Insetos , Relação Estrutura-Atividade , Ureia/análogos & derivados , Ureia/metabolismoRESUMO
The production of the blue pigment indigoidine has been achieved in the entomopathogenic bacterium Photorhabdus luminescens by a promoter exchange and in Escherichia coli following heterologous expression of the biosynthesis gene indC. Moreover, genes involved in the regulation of this previously "silent" biosynthesis gene cluster have been identified in P. luminescens.
