THE PROGRAM OF THE COMPLEX DIFFERENTIATED MEDICAL AND PSYCHOLOGICAL REHABILITATION OF THE PATIENTS WITH SUICIDAL BEHAVIOUR IN DEMENTIA.

The conceptual model of rehabilitation and suicidal behaviour prevention in dementia, considering the multiple components, is presented in the article. The developed program of the complex differentiated medical and psychological rehabilitation and suicidal behaviour prevention (MPRS BP) in patients with dementia is aimed at the preventive measures of the suicidal behaviour (SB) through the depressive symptoms reduction, patient's mind and cognitive status stabilization, self-aggression decreases, social functioning and independence increase in patients with dementia. The individual approach to the prevention of SB in patients with dementia considered the SB factors (extra- and intrapersonal), SB formation mechanisms (cognitive, depressive, and psychological), clinical psychopathological SB correlators (especially gender-based) in different types of dementia. Offered MPRS BP program is based on the complex approach to rehabilitation. It combines pharmacotherapy, psychotherapy (crisis therapy, rational psychotherapy, art therapy, family psychotherapy), psychoeducation, psychological training (cognitive, communicative and social skills training) keeping to the principles of systematicity, complexity, integrity, phasing, personal interventions, provision of assistance in time. According to the approbation results of the MPRS BP program in dementia, its high efficiency was demonstrated compared to the traditional treatment programs of this category of patients.

[MORPHOFUNCTIONAL ADJUSTMENT VASCULAR AND CELLULAR COMPONENTS OF THE CEREBELLAR CORTEX IN EXPOSURE TO BODY SULFATES OF COPPER, ZINC AND IRON].

In order to analyze the morphological and morphometric reconstructions of the vascular bed, and Purkinje cells of the cerebellar cortex of rats in long-term action (for 90 days) on the body of sulphates of copper, zinc and iron, an experiment was conducted on 48 adult white male rats weighing 200-250 g in age 5-7 months. We used anatomical, morphometric, statistical and common methods of microanatomical research. It was found that the combined effect on the body of sulphates of copper and zinc, and iron in the cerebellum has enough expressive toxicity, which affects the condition of the vascular bed, and Purkinje cells. The degree of morphological transformations is in direct proportion to the duration of the experiment. In the pathogenesis of violations leading role played by hypoxia, develop signs of swelling of the cerebellar cortex with signs hemorrhagic infiltration, the severity of which is maximum on the 60th day of the experiment.