[The action of bemitil on the self-regulation systems during short-term immobilization]. / Deistvie bemitila na sostoianie sistem samoreguliatsii pri kratkovremennoi immobilizatsii.

In the immobilized rats bemithyl (50 mg/kg in a single dose) was shown to normalize the state of the musculomotor and cardiovascular systems exerting the positive influence on the key links of the process of autoregulation in the form of the sedative (the central nervous system), stress-protective (hormonal regulation) and antihypoxic (metabolism) effects that characterizes it as the drug with the distinct antistress activity.

[The use of melipramine in treating patients with a depressive syndrome accompanied by motor retardation]. / Primenenie melipamina v lechenii bol'nykh s depressivnym sindromom, soprovozhdaiushchimsia dvigatel'noi zatormozhennost'iu.

A study of 49 patients with the depressive syndrome and showing different motor activity indicates that melipramin treatment proved more effective during the first week of treatment. The obtained data are confirmed by results of experiments with immobilized animals.

[Pharmacological activity and toxicity of neurotropic agents in experimental hypodynamia]. / Farmakologicheskaia aktivnost' i toksichnost' nekotorykh neirotropnykh sredstv v usloviiakh éksperimental'noi gipodinamii.

Comparison of ED50, the indices of pharmacological range, LD50, risk coefficients, the size of the area of toxic activity, maximal tolerated and absolute lethal doses showed in acute experiments on intact and "hypodynamic" mice that under conditions of a short-term tension-producing hypodynamia in the animals, the pharmacological activity of the test neurotropic agents exhibiting a central action changes, whereas their toxicity remains unchanged.

[Morphofunctional manifestations of rat adrenal cortical reaction to the administration of sodium bromide under conditions of hypodynamic stress]. / Morfofunktsional'nye proiavleniia kory nadpochechnikov krys na vvedenie bromida natriia v usloviiakh gipodinamicheskogo stressa

Experiments conducted on rats by employing functional and morphological methods of investigation showed bromine to weaken the function of the adrenal cortex in intach rats, producing changes analogous to those of a hypodynamic stress (2-hour immobilization on the operating table). A combined preliminary introduction of bromine and immobilization is attended by a less pronounced stress reaction and brings about normalization of the ascorbic acid content in the adrenals with the appearance of well-marked morphological signs pointing to the compensation of the adrenal cortex functions.