[Lipoprotein metabolism in rabbits with cholesterol-induced hyperlipoproteinemia during physical conditioning]. / Obmen lipoproteinov u krolikov pri giperlipoproteinemii, vyzvannoi vvedeniem kholesterina pod vliianiem fizicheskoi trenirovki.

Moderate exercises of rabbits inhibit the development of their cholesterol-induced hyperlipoproteinemia and accelerate normalization of higher lipid and lipoprotein concentrations after cessation of cholesterol delivery to the organism. Physical training of rabbits under hyperlipoproteinemia increases the activity of the blood plasma lipoproteinlipase and liver cholesterol-7-alpha-hydroxylase increases.

[Effect of restricted mobility on composition and metabolism of blood lipoproteins in rabbits]. / Vliianie ogranichennoi podvizhnosti na sostav i obmen lipoproteidov krovi u krolikov.

It is established that in rabbits under conditions of restricted mobility the decay of [3H] cholesterol-labelled lipoproteids of very low density is slown down. Simultaneously the activity of the blood plasma lipoproteidlipase decreases and the metabolism of low- and high-density lipoproteids is slown down. Under hypokinesia the total content of cholesterol and triacylglycerols increases both in the blood plasma and the composition of very low and low-density lipoproteids.

[Cholesterol metabolism in liver at different levels of motor activity]. / Obmen kholesterina v pecheni pri razlichnykh urovniakh dvigatel'noi aktivnosti.

Biosynthesis and decomposition of cholesterol were studied in the rabbit liver under a dosed physical loading. Judging from the intensity of [2-14C]acetate incorporation, the cholesterol biosynthesis intensity rises during loading and decreases under conditions of limited mobility. The cholesterol content in the liver tissue of trained animals is unchanged and in animals, who were under conditions of limited mobility, it rises as compared with the control. Using [7-3N1] cholesterol as a substrate, it established that the activity of cholesterol-7 alpha-hydroxylase, as compared to the initial level, is increased under training and decreased under conditions of low mobility. The enzymic activity was determined by the amount of released 3H2O.

[Effect of physical load on cholesterol content in different classes of lipoproteins of blood serum and their decomposition]. / Vliianie fizicheskoi nagruzki na soderzhanie kholesternia v razlichnykh klassakh lipoproteidov syvorotki krovi i ikh raspad.

An increase in the amount of cholesterol is established in blood serum high-density lipoproteins of rabbits which were subjected to moderate physical loads. Under these conditions an accelerated decay was also observed for lipoproteins of very low and low density.

[Dynamics of the intake and utilization of orally administered 1,2-propanediol in glycogen synthesis in the rat liver]. / Dinamika postupleniia i ispol'zovaniia oral'no vvedennogo 1,2-propandiola v sinteze glikogena pecheni krys

The possibility of an isocaloric substitution of 1,2-propandiol for carbohydrates in the food ration of rats was investigated. The inclusion of propandiol as a synthetic source of food energy in the alimentation in an amount comprising 20 per cent of the overall calorific value of carbohydrates does not affect adversely the growth intensity, nor does it produce any materials upsets in the metabolism of test animals. With its oral introduction in a dose of 1 g per 100 g of weight 1,2-propandiol is quickly absorbed, its level reaching the maximum in the blood and liver after a lapse of 1 hour with complete metabolization in the organism over a period of 12 hours. In fasting rats 1,2-propandiol is utilized as a precurser in the synthesis of glycogen and when introduced by the intraperitoneal route it does not influence the rate of the liver glycogen synthesis from glucose. Daily oral introduction of 2 g of 1,2-propandiol per 100 g of body weight for a space of three and seven days, superimposed upon a carbohydrate-rich diet, brings about a fall of the liver reserve glycogen level.