Biological effects of hesperidin, a Citrus flavonoid. (Note III): antihypertensive and diuretic activity in rat.

Hesperidin, the most important flavanone of Citrus sp., obtained from the solid residue of orange peel, showed antihypertensive and diuretic effects on normotensive rats and on spontaneously hypertensive rats (SHR).

Biological effects of hesperidin, a Citrus flavonoid. (note II): hypolipidemic activity on experimental hypercholesterolemia in rat.

Hesperidin, the most important flavanone of Citrus sp., significantly increases HDL and lowers cholesterol, LDL, total lipid and triglyceride plasma levels in normolipidemic rats and in rats with diet- and triton-induced hyperlipidemia.

Biological effects of hesperidin, a citrus flavonoid. (Note I): antiinflammatory and analgesic activity.

The present study was undertaken to define in vivo the antiinflammatory and analgesic activities of hesperidin, an important flavanone of Citrus sp.. We used hesperidin obtained from the solid residue of orange peel after an acidic pretreatment. Our results showed that hesperidin possesses significative antiinflammatory and analgesic effects.