RESUMO
The inhibitory effects of six contact antiphlogistics and two dermatocorticoids on hexadecane-induced hyperplasia of the guinea-pig skin were tested and compared. On the basis of the results obtained, the substances can be ranked in the following order of potency (percent inhibition of surface epithelial proliferation): acetylsalicylic acid (7.9%), phenylbutazone (12.5%), bufexamac (16.4%), bendazac (16.6%), oxyphenbutazone (19.5%), indomethacin (20.0%), hydrocortisone (20.6%) and fluocinolone acetonide (32.0%).
Assuntos
Anti-Inflamatórios/farmacologia , Pele/efeitos dos fármacos , Animais , Anti-Inflamatórios/administração & dosagem , Aspirina/farmacologia , Bufexamac/farmacologia , Fluocinolona Acetonida/farmacologia , Cobaias , Hidrocortisona/farmacologia , Hiperplasia , Indazóis/farmacologia , Indometacina/farmacologia , Oxifenilbutazona/farmacologia , Palmitatos/administração & dosagem , Fenilbutazona/farmacologia , Pele/patologiaRESUMO
In contrast to its antihyperplastic effect on pathological proliferation of the epidermis, salicylic acid promotes epidermopoiesis in the normal guinea pig skin. After the application of 1% w/w salicylic acid in acetone-ethanol for 4 weeks, the thickness of the surface epithelium was increased by 40% and that of the deep epithelium by 19%. The mitotic index rose by 17%.
Assuntos
Epiderme/efeitos dos fármacos , Mitose/efeitos dos fármacos , Salicilatos/farmacologia , Administração Tópica , Animais , Aspirina/administração & dosagem , Aspirina/farmacologia , Epiderme/fisiologia , Epitélio/efeitos dos fármacos , Epitélio/fisiologia , Cobaias , Hidrocortisona/administração & dosagem , Hidrocortisona/farmacologia , Índice Mitótico , Salicilatos/administração & dosagemRESUMO
Assays of steroidal and non-steroidal drugs in an experimental model of dermatitis induced in the ear of the rabbit by the application of a solution of croton oil revealed clearly differentiable inhibitory effects on the rise in skin temperature, the oedema and the increase in tissue mass due to the inflammatory process. The results obtained in this test system fairly accurately reflect the relative therapeutic potencies of known dermatocorticoids and, in conjunction with those found by other methods, afford a more exact characterization of the activity profiles of non-steroidal contra-inflammatory agents.
Assuntos
Anti-Inflamatórios/farmacologia , Pele/efeitos dos fármacos , Administração Tópica , Animais , Aspirina/farmacologia , Temperatura Corporal/efeitos dos fármacos , Clobetasol/farmacologia , Óleo de Cróton/efeitos adversos , Dermatite de Contato/etiologia , Avaliação de Medicamentos , Orelha Externa , Flumetasona/farmacologia , Hidrocortisona/farmacologia , Indometacina/farmacologia , Coelhos , Salicilatos/farmacologiaRESUMO
The acute contra-inflammatory effects of salicylic acid, three standard dermatocorticoids and four contact antiphlogistics have been investigated by means of a UV dermatitis inhibition test in the guinea pig. The substances tested had a distinct inhibitory effect on the development of erythema and can be ranked in the following ascending order of activity (percent of maximum possible score): bufexamac = 36%, salicylic acid = 37%, hydrocortisone = 44%, acetylsalicylic acid = 48%, flumethasone pivalate = 51%, fluocinolone acetonide = 51%, phenylbutazone = 56%, and indomethacin = 58%.
Assuntos
Dermatite/tratamento farmacológico , Salicilatos/uso terapêutico , Administração Tópica , Animais , Aspirina/administração & dosagem , Aspirina/uso terapêutico , Bufexamac/administração & dosagem , Bufexamac/uso terapêutico , Flumetasona/administração & dosagem , Flumetasona/uso terapêutico , Fluocinolona Acetonida/administração & dosagem , Fluocinolona Acetonida/uso terapêutico , Cobaias , Hidrocortisona/administração & dosagem , Hidrocortisona/uso terapêutico , Indometacina/administração & dosagem , Indometacina/uso terapêutico , Masculino , Fenilbutazona/administração & dosagem , Fenilbutazona/uso terapêutico , Salicilatos/administração & dosagemRESUMO
The influence of salicylic acid on pathological epithelial proliferation has been evaluated by means of the peidermal hyperplasia inhibition test in the guinea pig. 3% w/w salicylic acid dissolved in ethanol reduced surface epithelial hyperplasia by 15%, i.e. exhibited activity comparable to that of hydrocortisone 0.1% w/w. 1% w/w salicylic acid dissolved in a dimethylacetamide-acetone-ethanol mixture exerted an even greater degree of antihyperplastic activity on the surface epithelium (-18%) and also a marked inhibitory effect on deep epithelial proliferation (-10%).
