[Filariasis in foreign immigrants]. / Filariosen bei eingereisten Ausländern.

Among the patients of the Clinic for Infectious and Tropical Diseases of the County Hospital St. George Leipzig the frequency of the infestment with microfilaria in immigrated foreigners was established. Of 1925 examined patients 78 (4.1%) were infested with microfilaria. In 27 patients we succeeded in proving Wuchereria bancrofti and in 3 Brugia malayi, 43 showed Acanthocheilonema perstans, in 5 cases a double infection was present.

[Bicycle ergometric testing in the acute phase of liver disease with particular reference to changes in serum enzymes]. / Fahrradergometrische Belastung in der akuten Phase von Leberkrankheiten unter besonderer Berücksichtigung des Serumenzymverlaufes.

It is reported on 20 patients (17 women, 3 men) who had undergone a bicycle-ergometric load in the acute phase of virus hepatitis (an average at the 16th day after admission to hospital). Among the significant changes of the activity the slight increase of SGPT 30 minutes after the end of the load as well as the clear decrease of the enzyme activities of SGPT and SGOT below the initial value 48 hours after load are particularly to be emphasized. LDH and CPK exhibited only insignificant changes of activity. It remains open to what extent there exists a connection between the ECG-changes proved in about half the women and the virus hepatitis as a cyclic infectious disease. In the 20 patients examined a clinically recognizable deterioration in the course of the disease by the load examination did not appear.

[Physical capacity of patients with liver diseases as well as its significance for therapy and evaluation]. / Zur Frage der körperlichen Belastkarkeit bei Patienten mit Lebererkrankungen sowie deren Bedeutung für Therapie und Begutachtung.

In 50 patients with different liver diseases (20 with subsided viral hepatitis and 30 with degenerative liver damages) the serum enzyme course of SGOT, SGPT, LDH and CPK was investigated after ergometer load. The enzymes were estimated before as well as 1/2, 2, 4, 24, and 48 hours after load. 48 hours after load additionally the liver biopsy after Menghini was carried out. According to the histological findings the 20 patients with viral hepatitis were subdivided into 13 with still active and 7 with residual hepatitis as well as the 30 patients with degenerative liver damages into 15 with toxical hepatosis, 6 with fatty degeneration of the liver cells and 9 with signs of metabolic activation. Since the significant increases of enzymes could not be proved in any of the fours enzymes 1/2 to 48 hours after load we are of the opinion that the liver, independent on the kind of the lesion, better tolerates physical work. Moreover, it seems that load investigations under ergometry with estimation of the course of the serum enzymes are unsuited for the judgment of the degree of activity and the degree of cure of liver diseases, respectively.

[Toxic hepatoses due to Gravistat]. / Toxische Hepatose durch Gravistat.

With the help of 5 cases with toxic hepatosis by administration of Gravistat the problems concerning ovulation inhibitor and toxic hepatosis were explained. The clinical, paraclinical and histological findings may be pronounced differently. Anamnestically in prescribing ovulation inhibitors particularly a jaundice during pregnancy or a pronounced pruritus in the 3rd trimester of the pregnancy must be taken into consideration. Toxic liver damage may appear not only when the ovulation inhibitor is given the first time, but also after changing it. For this reasons idiopathic jaundice during pregnancy and condition after toxic hepatosis by ovulation inhibitor in every case must be regarded as contraindications for the application of oral contraceptives. In order to establish subclinical courses a control of transaminases in the first three cycles of using the remedies is to be demanded.

[Therapeutic results using combined antibiotic therapy in chronic carriers]. / Behandlungsergebnisse mit kombinierter Antibiotikatherapie bei Dauerausscheidern.

From 1969 to January 1976 82 chronic carriers underwent a sanitation treatment. This treatment consists in an antibiotic combination treatment with ampicillin and canamycin during 24 to 18 days, in which case possibly simultaneously the cholecystectomy is striven for. In chronic carriers of S. typhi in 37 cases the combined antibiotic-operative treatment led to the permanent success. In chronic carriers of S. paratyphi B 21 of 22 cases were present. In patients with condition after cholecystectomy in every case one failure was present. In purely conservative approach the coefficient of success was 50 and 78%.

[Steatosis of the liver cells--subclinical liver damage or more?]. / Leberzellverfettung--subklinischer Leberschaden oder mehr

The basis of the results are histological investigations of the preparations of liver biopsy of 134 donors who were evident in the SGPT-screening and of 100 patients with viral hepatitis after normalisation of the clinical and the laboratory-chemical findings. The liver casts were got by means of Menghini's method. In patients with hepatitis we found in 43% and in donors in 44% a small-droplet to medium size droplet fatty change in the liver cells. A large-droplet fatty change in the liver cells occurred in the patients with hepatitis only in 2% of the cases, in the donors, however, in 25%. Factors which favour the fatty change in the liver cells, such as adiposis, alcohol and prednisone therapy, were excluded. Our results increase the suspicion that in one part of the clinically healthy donors who are evident in the SGPT-screening we have to do with persons who are in the healing phase of a viral hepatitis with abortive course. Therefore, these persons should be excluded from blood donation. Donors and patients with the findings of a large-droplet fatty change in the liver cells must be investigated systemically. Blood donors with the findings of a fatty liver may remain in the team of donors.

[The significance of histological findings for the final clinical evaluation in acute viral hepatitis]. / Die Bedeutung histologischer Befunde für die klinische Abschlussuntersuchung bei akuter Virushepatitis

Clinical and morphological findings of 406 patients who fell ill from a virus hepatitis were established according to the data and statistically evaluated to find relations between clinical, serochemical and histological criteria. The results were tested statistically. Clinical and paraclinical findings at the end of the hospital treatment give no evidence concerning the histological degree of cure of the acute virus hepatitis. In normalised clinical and serochemical findings we could morphologically prove an acute hepatitis still in 27.4%. Anamnestic data and severity of the clinical course have no relation to the histological diagnosis at the end of the hospital treatment with clinical and serochemical recovery. Therefore, at the end of the hospital treatment we recommend the liver biopsy as final examination. The most favourable date of the liver biopsy would, however, be between the 6th and 12th week after discharge.